{"id":590,"date":"2017-10-26T15:03:24","date_gmt":"2017-10-26T15:03:24","guid":{"rendered":"https:\/\/courses.lumenlearning.com\/sunynutrition\/?post_type=chapter&p=590"},"modified":"2017-11-13T20:25:54","modified_gmt":"2017-11-13T20:25:54","slug":"7-34-red-blood-cell-macronutrient-metabolism","status":"publish","type":"chapter","link":"https:\/\/courses.lumenlearning.com\/atd-herkimer-nutrition\/chapter\/7-34-red-blood-cell-macronutrient-metabolism\/","title":{"raw":"7.34 Red Blood Cell Macronutrient Metabolism","rendered":"7.34 Red Blood Cell Macronutrient Metabolism"},"content":{"raw":"
\r\n\r\nRed blood cells are the most limited of the extrahepatic tissues because they do not contain a nucleus or other cell organelles, most notably mitochondria.\r\n
\r\n\r\n[caption id=\"\" align=\"aligncenter\" width=\"556\"]\"\" Figure 7.341 Red blood cells do not contain mitochondria1<\/sup>[\/caption]\r\n\r\n<\/div>\r\nAs a result, compared to the extrahepatic tissues, in red blood cells the following pathways are not performed or are not important:\r\n\r\nGlycogen synthesis and breakdown\r\n\r\nLactate breakdown\r\n\r\nFatty acid synthesis and breakdown\r\n\r\nTriglyceride synthesis and breakdown\r\n\r\nProtein synthesis and breakdown\r\n\r\nKetone body breakdown\r\n\r\nThese pathways are crossed off in the figure below.\r\n
\r\n\r\n[caption id=\"\" align=\"aligncenter\" width=\"1130\"]\"\" Figure 7.342 The metabolic pathways that are not performed or important in the red blood cells, compared to extrahepatic tissues as a whole are crossed off2<\/sup>[\/caption]\r\n\r\n<\/div>\r\nIf all those pathways are removed, only glycolysis is left, where pyruvate is converted to lactate.\r\n
\r\n\r\n[caption id=\"\" align=\"aligncenter\" width=\"431\"]\"\" Figure 7.343 Red blood cell metabolic capability[\/caption]\r\n\r\n<\/div>\r\nThus, red blood cells are one-trick ponies, only being able to perform glycolysis and produce lactate.\r\n
\r\n\r\n[caption id=\"\" align=\"aligncenter\" width=\"1118\"]\"\" Figure 7.344 Red blood cells are one-trick ponies[\/caption]\r\n\r\n<\/div>\r\nReferences & Links<\/b>\r\n\r\n1. http:\/\/en.wikipedia.org\/wiki\/Mitochondrion\r\n\r\n2. http:\/\/en.wikipedia.org\/wiki\/File:CellRespiration.svg\r\n\r\n<\/div>","rendered":"
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Red blood cells are the most limited of the extrahepatic tissues because they do not contain a nucleus or other cell organelles, most notably mitochondria.<\/p>\n

\n
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Figure 7.341 Red blood cells do not contain mitochondria1<\/sup><\/p>\n<\/div>\n<\/div>\n

As a result, compared to the extrahepatic tissues, in red blood cells the following pathways are not performed or are not important:<\/p>\n

Glycogen synthesis and breakdown<\/p>\n

Lactate breakdown<\/p>\n

Fatty acid synthesis and breakdown<\/p>\n

Triglyceride synthesis and breakdown<\/p>\n

Protein synthesis and breakdown<\/p>\n

Ketone body breakdown<\/p>\n

These pathways are crossed off in the figure below.<\/p>\n

\n
\"\"<\/p>\n

Figure 7.342 The metabolic pathways that are not performed or important in the red blood cells, compared to extrahepatic tissues as a whole are crossed off2<\/sup><\/p>\n<\/div>\n<\/div>\n

If all those pathways are removed, only glycolysis is left, where pyruvate is converted to lactate.<\/p>\n

\n
\"\"<\/p>\n

Figure 7.343 Red blood cell metabolic capability<\/p>\n<\/div>\n<\/div>\n

Thus, red blood cells are one-trick ponies, only being able to perform glycolysis and produce lactate.<\/p>\n

\n
\"\"<\/p>\n

Figure 7.344 Red blood cells are one-trick ponies<\/p>\n<\/div>\n<\/div>\n

References & Links<\/b><\/p>\n

1. http:\/\/en.wikipedia.org\/wiki\/Mitochondrion<\/p>\n

2. http:\/\/en.wikipedia.org\/wiki\/File:CellRespiration.svg<\/p>\n<\/div>\n\n\t\t\t

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Candela Citations<\/h3>\n\t\t\t\t\t
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