Extracellular Matrix of Animal Cells
The extracellular matrix of animal cells holds cells together to form a tissue and allow tissues to communicate with each other.
Explain the role of the extracellular matrix in animal cells
- The extracellular matrix of animal cells is made up of proteins and carbohydrates.
- Cell communication within tissue and tissue formation are main functions of the extracellular matrix of animal cells.
- Tissue communication is kick-started when a molecule within the matrix binds a receptor; the end results are conformational changes that induce chemical signals that ultimately change activities within the cell.
- collagen: Any of more than 28 types of glycoprotein that forms elongated fibers, usually found in the extracellular matrix of connective tissue.
- proteoglycan: Any of many glycoproteins that have heteropolysaccharide side chains
- extracellular matrix: All the connective tissues and fibres that are not part of a cell, but rather provide support.
Extracellular Matrix of Animal Cells
Most animal cells release materials into the extracellular space. The primary components of these materials are proteins. Collagen is the most abundant of the proteins. Its fibers are interwoven with carbohydrate-containing protein molecules called proteoglycans. Collectively, these materials are called the extracellular matrix. Not only does the extracellular matrix hold the cells together to form a tissue, but it also allows the cells within the tissue to communicate with each other.
How does this cell communication occur? Cells have protein receptors on the extracellular surfaces of their plasma membranes. When a molecule within the matrix binds to the receptor, it changes the molecular structure of the receptor. The receptor, in turn, changes the conformation of the microfilaments positioned just inside the plasma membrane. These conformational changes induce chemical signals inside the cell that reach the nucleus and turn “on” or “off” the transcription of specific sections of DNA. This affects the production of associated proteins, thus changing the activities within the cell.
An example of the role of the extracellular matrix in cell communication can be seen in blood clotting. When the cells lining a blood vessel are damaged, they display a protein receptor called tissue factor. When a tissue factor binds with another factor in the extracellular matrix, it causes platelets to adhere to the wall of the damaged blood vessel and stimulates the adjacent smooth muscle cells in the blood vessel to contract (thus constricting the blood vessel). Subsequently, a series of steps are initiated which then prompt the platelets to produce clotting factors.
Intercellular junctions provide plant and animal cells with the ability to communicate through direct contact.
Describe the purpose of intercellular junctions in the structure of cells
- Plasmodesmata are intercellular junctions between plant cells that enable the transportation of materials between cells.
- A tight junction is a watertight seal between two adjacent animal cells, which prevents materials from leaking out of cells.
- Desmosomes connect adjacent cells when cadherins in the plasma membrane connect to intermediate filaments.
- Similar to plasmodesmata, gap junctions are channels between adjacent cells that allow for the transport of ions, nutrients, and other substances.
- plasmodesma: A microscopic channel traversing the cell walls of plant cells and some algal cells, enabling transport and communication between them.
- connexon: An assembly of six connexins forming a bridge called a gap junction between the cytoplasms of two adjacent cells.
- occludin: Together with the claudin group of proteins, it is the main component of the tight junctions.
The extracellular matrix allows cellular communication within tissues through conformational changes that induce chemical signals, which ultimately transform activities within the cell. However, cells are also capable of communicating with each other via direct contact through intercellular junctions.
There are some differences in the ways that plant and animal cells communicate directly. Plasmodesmata are junctions between plant cells, whereas animal cell contacts are carried out through tight junctions, gap junctions, and desmosomes.
Junctions in Plant Cells
In general, long stretches of the plasma membranes of neighboring plant cells cannot touch one another because they are separated by the cell wall that surrounds each cell. How then can a plant transfer water and other soil nutrients from its roots, through its stems, and to its leaves? This transport primarily uses the vascular tissues (xylem and phloem); however, there are also structural modifications called plasmodesmata (singular: plasmodesma) that facilitate direct communication in plant cells. Plasmodesmata are numerous channels that pass between cell walls of adjacent plant cells and connect their cytoplasm; thereby, enabling materials to be transported from cell to cell, and thus throughout the plant.
Junctions in Animal Cells
Communication between animal cells can be carried out through three types of junctions. The first, a tight junction, is a watertight seal between two adjacent animal cells. The cells are held tightly against each other by proteins (predominantly two proteins called claudins and occludins). This tight adherence prevents materials from leaking between the cells. These junctions are typically found in epithelial tissues that line internal organs and cavities and comprise most of the skin. For example, the tight junctions of the epithelial cells lining your urinary bladder prevent urine from leaking out into the extracellular space.
Also found only in animal cells are desmosomes, the second type of intercellular junctions in these cell types. Desmosomes act like spot welds between adjacent epithelial cells, connecting them. Short proteins called cadherins in the plasma membrane connect to intermediate filaments to create desmosomes. The cadherins join two adjacent cells together and maintain the cells in a sheet-like formation in organs and tissues that stretch, such as the skin, heart, and muscles.
Lastly, similar to plasmodesmata in plant cells, gap junctions are the third type of direct junction found within animal cells. These junctions are channels between adjacent cells that allow for the transport of ions, nutrients, and other substances that enable cells to communicate. Structurally, however, gap junctions and plasmodesmata differ. Gap junctions develop when a set of six proteins (called connexins) in the plasma membrane arrange themselves in an elongated doughnut-like configuration called a connexon. When the pores (“doughnut holes”) of connexons in adjacent animal cells align, a channel between the two cells forms. Gap junctions are particularly important in cardiac muscle. The electrical signal for the muscle to contract is passed efficiently through gap junctions, which allows the heart muscle cells to contract in tandem.