As authors, you may dread receiving reviewer comments asking for major revisions. It’s daunting to rework something for which you have already taken great pains. But don’t be tempted to give up. Most often, the final outcome is worth the effort. Here are some pointers on how to respond to such comments.

• Take a break: Initial irritation is only natural. Take time off and then read the comments again carefully and objectively to ensure that you have clearly understood the reviewers’ concerns. 
• Articulate well-reasoned point-by-point responses: Number the reviewers’ points and consider their merits, issues, and any questions that arise sequentially. This is an effective way to inventory their advice and make sure that you’ve evaluated all of it.
• Pay attention to detail: Details are important when considering how to address each concern. For example, if a reviewer has said that you need to include/reinterpret data, go back to from where the information derived, consider the reviewer’s comments in relation to what you initially wrote, and reevaluate how what changes, if any, are required in terms of ho such data was interpreted and included. 
• Watch your tone: Remember, the reviewers are critiquing your work, not you. Do not let their feedback color any future interactions you have with them. If you disagree on some point, that is fine, but consider why you disagree with rational thought.
• Appreciate the reviewers’ work: Peer reviewers invest their own time in reviewing your writing. Their intention is to help you improve your writing, and hopefully earn higher grades as a result. Take advantage of their advice. In fact, a long list of detailed reviewer comments usually means that reviewer has spent considerable time evaluating your work and providing constructive feedback. Be sure to thank reviewers for their consideration and effort.