{"id":528,"date":"2017-10-26T14:31:28","date_gmt":"2017-10-26T14:31:28","guid":{"rendered":"https:\/\/courses.lumenlearning.com\/sunynutrition\/?post_type=chapter&p=528"},"modified":"2017-11-13T20:03:02","modified_gmt":"2017-11-13T20:03:02","slug":"6-33-de-novo-lipogenesis-fatty-acid-synthesis","status":"publish","type":"chapter","link":"https:\/\/courses.lumenlearning.com\/suny-herkimer-nutritionflex\/chapter\/6-33-de-novo-lipogenesis-fatty-acid-synthesis\/","title":{"raw":"6.33 De novo Lipogenesis (Fatty Acid Synthesis)","rendered":"6.33 De novo Lipogenesis (Fatty Acid Synthesis)"},"content":{"raw":"
\r\n\r\nDe novo in Latin means \"from the beginning.\" Thus, de novo<\/i> lipogenesis is the synthesis of fatty acids, beginning with acetyl-CoA. Acetyl-CoA has to first move out of the mitochondria, where it is then converted to malonyl-CoA (3 carbons). Malonyl-CoA then is combined with another acetyl-CoA to form a 4 carbon fatty acid (1 carbon is given off as CO2). The addition of 2 carbons is repeated through a similar process 7 times to produce a 16 carbon fatty acid1<\/sup>.\r\n
\r\n\r\n[caption id=\"\" align=\"aligncenter\" width=\"1110\"]\"\" Figure 6.331 Fatty acid synthesis2<\/sup>[\/caption]\r\n\r\n<\/div>\r\nMost fatty acids synthesized will be esterified into triglycerides for storage.\r\n\r\nReferences<\/b>\r\n\r\n1. Gropper SS, Smith JL, Groff JL. (2008) Advanced nutrition and human metabolism. Belmont, CA: Wadsworth Publishing.\r\n\r\n2. http:\/\/en.wikipedia.org\/wiki\/Mitochondrion\r\n\r\n<\/div>","rendered":"
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De novo in Latin means “from the beginning.” Thus, de novo<\/i> lipogenesis is the synthesis of fatty acids, beginning with acetyl-CoA. Acetyl-CoA has to first move out of the mitochondria, where it is then converted to malonyl-CoA (3 carbons). Malonyl-CoA then is combined with another acetyl-CoA to form a 4 carbon fatty acid (1 carbon is given off as CO2). The addition of 2 carbons is repeated through a similar process 7 times to produce a 16 carbon fatty acid1<\/sup>.<\/p>\n

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Figure 6.331 Fatty acid synthesis2<\/sup><\/p>\n<\/div>\n<\/div>\n

Most fatty acids synthesized will be esterified into triglycerides for storage.<\/p>\n

References<\/b><\/p>\n

1. Gropper SS, Smith JL, Groff JL. (2008) Advanced nutrition and human metabolism. Belmont, CA: Wadsworth Publishing.<\/p>\n

2. http:\/\/en.wikipedia.org\/wiki\/Mitochondrion<\/p>\n<\/div>\n\n\t\t\t

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Candela Citations<\/h3>\n\t\t\t\t\t
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