{"id":196,"date":"2021-02-18T16:06:12","date_gmt":"2021-02-18T16:06:12","guid":{"rendered":"https:\/\/courses.lumenlearning.com\/suny-hvcc-healthpsychology\/?post_type=chapter&#038;p=196"},"modified":"2021-02-18T16:08:10","modified_gmt":"2021-02-18T16:08:10","slug":"alcoholism","status":"publish","type":"chapter","link":"https:\/\/courses.lumenlearning.com\/suny-hvcc-healthpsychology\/chapter\/alcoholism\/","title":{"raw":"Alcoholism","rendered":"Alcoholism"},"content":{"raw":"<b>Alcoholism<\/b>\u00a0is, broadly, any drinking of\u00a0<a title=\"Alcohol (drug)\" href=\"https:\/\/en.wikipedia.org\/wiki\/Alcohol_(drug)\">alcohol<\/a>\u00a0that results in significant\u00a0<a title=\"Mental health\" href=\"https:\/\/en.wikipedia.org\/wiki\/Mental_health\">mental<\/a>\u00a0or physical\u00a0<a title=\"Health\" href=\"https:\/\/en.wikipedia.org\/wiki\/Health\">health<\/a>\u00a0problems.<sup id=\"cite_ref-14\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-14\">[14]<\/a><\/sup>\u00a0Alcoholism is not a recognized diagnostic entity. Predominant diagnostic classifications are\u00a0<b>alcohol use disorder<\/b><sup id=\"cite_ref-NIH2013_2-2\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-NIH2013-2\">[2]<\/a><\/sup>\u00a0(<a title=\"DSM-5\" href=\"https:\/\/en.wikipedia.org\/wiki\/DSM-5\">DSM-5<\/a>)<sup id=\"cite_ref-DSM5_4-4\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-DSM5-4\">[4]<\/a><\/sup>\u00a0or\u00a0<a title=\"Alcohol dependence\" href=\"https:\/\/en.wikipedia.org\/wiki\/Alcohol_dependence\">alcohol dependence<\/a>\u00a0(<a title=\"ICD-11\" href=\"https:\/\/en.wikipedia.org\/wiki\/ICD-11\">ICD-11<\/a>).<sup id=\"cite_ref-15\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-15\">[15]<\/a><\/sup>\r\n<h2><span id=\"Signs_and_symptoms\" class=\"mw-headline\">Signs and symptoms<\/span><\/h2>\r\n<div class=\"thumb tright\">\r\n<div class=\"thumbinner\">\r\n<div id=\"mwe_player_0\" class=\"PopUpMediaTransform\" style=\"margin: 0px auto;width: 350px\"><img class=\"aligncenter\" src=\"https:\/\/upload.wikimedia.org\/wikipedia\/commons\/thumb\/4\/45\/What_Alcohol_Does_to_Your_Body.webm\/350px--What_Alcohol_Does_to_Your_Body.webm.jpg\" alt=\"File:What Alcohol Does to Your Body.webm\" \/><\/div>\r\n<div class=\"thumbcaption\">\r\n<div class=\"magnify\"><\/div>\r\n<\/div>\r\n<\/div>\r\n<\/div>\r\nThe risk of alcohol dependence begins at low levels of drinking and increases directly with both the volume of alcohol consumed and a pattern of\u00a0<a title=\"Binge drinking\" href=\"https:\/\/en.wikipedia.org\/wiki\/Binge_drinking\">drinking larger amounts on an occasion<\/a>, to the point of intoxication, which is sometimes called \"binge drinking\".\r\n<h2><span id=\"Alcohol_misuse\" class=\"mw-headline\">Alcohol misuse<\/span><\/h2>\r\n<div class=\"thumb tright\">\r\n<div class=\"thumbinner\">\r\n\r\n[caption id=\"\" align=\"alignright\" width=\"350\"]<a class=\"image\" href=\"https:\/\/en.wikipedia.org\/wiki\/File:Possible_long-term_effects_of_ethanol.svg\"><img class=\"thumbimage\" src=\"https:\/\/upload.wikimedia.org\/wikipedia\/commons\/thumb\/3\/34\/Possible_long-term_effects_of_ethanol.svg\/350px-Possible_long-term_effects_of_ethanol.svg.png\" alt=\"\" width=\"350\" height=\"250\" \/><\/a> Effects of alcohol on the body[\/caption]\r\n\r\n<div class=\"thumbcaption\">\r\n<div class=\"magnify\"><\/div>\r\nSome of the possible\u00a0<a class=\"mw-redirect\" title=\"Long-term effects of ethanol\" href=\"https:\/\/en.wikipedia.org\/wiki\/Long-term_effects_of_ethanol\">long-term effects of ethanol<\/a>\u00a0an individual may develop. Additionally, in pregnant women, alcohol can cause\u00a0<a class=\"mw-redirect\" title=\"Fetal alcohol syndrome\" href=\"https:\/\/en.wikipedia.org\/wiki\/Fetal_alcohol_syndrome\">fetal alcohol syndrome<\/a>.\r\n\r\n<\/div>\r\n<\/div>\r\n<\/div>\r\nAlcoholism is characterised by an increased\u00a0<a title=\"Alcohol tolerance\" href=\"https:\/\/en.wikipedia.org\/wiki\/Alcohol_tolerance\">tolerance<\/a>\u00a0to alcohol\u00a0\u2013 which means that an individual can consume more alcohol\u00a0\u2013 and\u00a0<a title=\"Physical dependence\" href=\"https:\/\/en.wikipedia.org\/wiki\/Physical_dependence\">physical dependence<\/a>\u00a0on alcohol, which makes it hard for an individual to control their consumption. The physical dependency caused by alcohol can lead to an affected individual having a very strong urge to drink alcohol. These characteristics play a role in decreasing an alcoholic's ability to stop drinking.<sup id=\"cite_ref-Hoffman-1996_29-0\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-Hoffman-1996-29\">[29]<\/a><\/sup>\u00a0Alcoholism can have adverse effects on mental health, contributing to psychiatric disorders and increasing the risk of suicide. A\u00a0<a title=\"Depression (mood)\" href=\"https:\/\/en.wikipedia.org\/wiki\/Depression_(mood)\">depressed mood<\/a>\u00a0is a common symptom of heavy alcohol drinkers.<sup id=\"cite_ref-30\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-30\">[30]<\/a><\/sup><sup id=\"cite_ref-drug_abuse_prevention_a03_31-0\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-drug_abuse_prevention_a03-31\">[31]<\/a><\/sup>\r\n<div class=\"textbox examples\">\r\n<h3>watch<\/h3>\r\n[embed]https:\/\/youtu.be\/mfMBCBLVCvY[\/embed]\r\n\r\n<\/div>\r\n&nbsp;\r\n<h3><span id=\"Warning_signs\" class=\"mw-headline\">Warning signs<\/span><\/h3>\r\nWarning signs of alcoholism include the consumption of increasing amounts of alcohol and frequent intoxication, preoccupation with drinking to the exclusion of other activities, promises to quit drinking and failure to keep those promises, the inability to remember what was said or done while drinking (colloquially known as \"blackouts\"), personality changes associated with drinking, denial or the making of excuses for drinking, the refusal to admit excessive drinking, dysfunction or other problems at work or school, the loss of interest in personal appearance or hygiene, marital and economic problems, and the complaint of poor health, with loss of appetite, respiratory infections, or increased anxiety.<sup id=\"cite_ref-32\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-32\">[32]<\/a><\/sup>\r\n<h4><span id=\"Physical\" class=\"mw-headline\">Physical<\/span><\/h4>\r\n<h5><span id=\"Short-term_effects\" class=\"mw-headline\">Short-term effects<\/span><\/h5>\r\n<div class=\"hatnote navigation-not-searchable\" role=\"note\">Main article:\u00a0<a title=\"Short-term effects of alcohol consumption\" href=\"https:\/\/en.wikipedia.org\/wiki\/Short-term_effects_of_alcohol_consumption\">Short-term effects of alcohol consumption<\/a><\/div>\r\nDrinking enough to cause a\u00a0<a class=\"mw-redirect\" title=\"Blood alcohol concentration\" href=\"https:\/\/en.wikipedia.org\/wiki\/Blood_alcohol_concentration\">blood alcohol concentration<\/a>\u00a0(BAC) of 0.03\u20130.12% typically causes an overall improvement in mood and possible\u00a0<a title=\"Euphoria\" href=\"https:\/\/en.wikipedia.org\/wiki\/Euphoria\">euphoria<\/a>\u00a0(a \"happy\" feeling), increased self-confidence and sociability, decreased anxiety, a\u00a0<a title=\"Alcohol flush reaction\" href=\"https:\/\/en.wikipedia.org\/wiki\/Alcohol_flush_reaction\">flushed, red appearance in the face<\/a>\u00a0and impaired judgment and fine muscle coordination. A BAC of 0.09% to 0.25% causes\u00a0<a title=\"Lethargy\" href=\"https:\/\/en.wikipedia.org\/wiki\/Lethargy\">lethargy<\/a>,\u00a0<a title=\"Sedation\" href=\"https:\/\/en.wikipedia.org\/wiki\/Sedation\">sedation<\/a>, balance problems and blurred vision. A BAC of 0.18% to 0.30% causes profound confusion, impaired speech (e.g. slurred speech), staggering, dizziness and vomiting. A BAC from 0.25% to 0.40% causes\u00a0<a title=\"Stupor\" href=\"https:\/\/en.wikipedia.org\/wiki\/Stupor\">stupor<\/a>, unconsciousness,\u00a0<a title=\"Anterograde amnesia\" href=\"https:\/\/en.wikipedia.org\/wiki\/Anterograde_amnesia\">anterograde amnesia<\/a>, vomiting (death may occur due to\u00a0<a title=\"Pulmonary aspiration\" href=\"https:\/\/en.wikipedia.org\/wiki\/Pulmonary_aspiration\">inhalation of vomit<\/a>\u00a0while unconscious) and\u00a0<a class=\"mw-redirect\" title=\"Respiratory depression\" href=\"https:\/\/en.wikipedia.org\/wiki\/Respiratory_depression\">respiratory depression<\/a>\u00a0(potentially life-threatening). A BAC from 0.35% to 0.80% causes a\u00a0<a title=\"Coma\" href=\"https:\/\/en.wikipedia.org\/wiki\/Coma\">coma<\/a>\u00a0(unconsciousness), life-threatening respiratory depression and possibly fatal\u00a0<a class=\"mw-redirect\" title=\"Alcohol poisoning\" href=\"https:\/\/en.wikipedia.org\/wiki\/Alcohol_poisoning\">alcohol poisoning<\/a>. With all alcoholic beverages,\u00a0<a class=\"mw-redirect\" title=\"Drinking and driving\" href=\"https:\/\/en.wikipedia.org\/wiki\/Drinking_and_driving\">drinking while driving<\/a>, operating an aircraft or heavy machinery increases the risk of an accident; many countries have penalties for drunk driving.\r\n<h5><span id=\"Long-term_effects\" class=\"mw-headline\">Long-term effects<\/span><\/h5>\r\n<div class=\"hatnote navigation-not-searchable\" role=\"note\">See also:\u00a0<a class=\"mw-redirect\" title=\"Long-term effects of alcohol consumption\" href=\"https:\/\/en.wikipedia.org\/wiki\/Long-term_effects_of_alcohol_consumption\">Long-term effects of alcohol consumption<\/a><\/div>\r\nHaving more than one drink a day for women or two drinks for men increases the risk of heart disease,\u00a0<a class=\"mw-redirect\" title=\"High blood pressure\" href=\"https:\/\/en.wikipedia.org\/wiki\/High_blood_pressure\">high blood pressure<\/a>,\u00a0<a title=\"Atrial fibrillation\" href=\"https:\/\/en.wikipedia.org\/wiki\/Atrial_fibrillation\">atrial fibrillation<\/a>, and\u00a0<a title=\"Stroke\" href=\"https:\/\/en.wikipedia.org\/wiki\/Stroke\">stroke<\/a>.<sup id=\"cite_ref-Kee2014_33-0\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-Kee2014-33\">[33]<\/a><\/sup>\u00a0Risk is greater with\u00a0<a title=\"Binge drinking\" href=\"https:\/\/en.wikipedia.org\/wiki\/Binge_drinking\">binge drinking<\/a>, which may also result in violence or accidents. About 3.3\u00a0million deaths (5.9% of all deaths) are believed to be due to alcohol each year.<sup id=\"cite_ref-NIH2015Stats_13-3\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-NIH2015Stats-13\">[13]<\/a><\/sup>\u00a0Alcoholism reduces a person's life expectancy by around ten years<sup id=\"cite_ref-Schu2014_26-1\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-Schu2014-26\">[26]<\/a><\/sup>\u00a0and alcohol use is the third leading cause of early death in the United States.<sup id=\"cite_ref-Kee2014_33-1\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-Kee2014-33\">[33]<\/a><\/sup>\u00a0No professional medical association recommends that people who are nondrinkers should start drinking.<sup id=\"cite_ref-Kee2014_33-2\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-Kee2014-33\">[33]<\/a><\/sup><sup id=\"cite_ref-34\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-34\">[34]<\/a><\/sup>\u00a0Long-term alcohol misuse can cause a number of physical symptoms, including\u00a0<a title=\"Cirrhosis\" href=\"https:\/\/en.wikipedia.org\/wiki\/Cirrhosis\">cirrhosis<\/a>\u00a0of the liver,\u00a0<a title=\"Pancreatitis\" href=\"https:\/\/en.wikipedia.org\/wiki\/Pancreatitis\">pancreatitis<\/a>,\u00a0<a title=\"Epilepsy\" href=\"https:\/\/en.wikipedia.org\/wiki\/Epilepsy\">epilepsy<\/a>,\u00a0<a title=\"Polyneuropathy\" href=\"https:\/\/en.wikipedia.org\/wiki\/Polyneuropathy\">polyneuropathy<\/a>,\u00a0<a class=\"mw-redirect\" title=\"Wernicke-Korsakoff syndrome\" href=\"https:\/\/en.wikipedia.org\/wiki\/Wernicke-Korsakoff_syndrome\">alcoholic dementia<\/a>, heart disease, nutritional deficiencies,\u00a0<a class=\"mw-redirect\" title=\"Duodenal ulcer\" href=\"https:\/\/en.wikipedia.org\/wiki\/Duodenal_ulcer\">peptic ulcers<\/a><sup id=\"cite_ref-35\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-35\">[35]<\/a><\/sup>\u00a0and\u00a0<a title=\"Sexual dysfunction\" href=\"https:\/\/en.wikipedia.org\/wiki\/Sexual_dysfunction\">sexual dysfunction<\/a>, and can eventually be fatal. Other physical effects include an increased risk of developing\u00a0<a title=\"Cardiovascular disease\" href=\"https:\/\/en.wikipedia.org\/wiki\/Cardiovascular_disease\">cardiovascular disease<\/a>,\u00a0<a title=\"Malabsorption\" href=\"https:\/\/en.wikipedia.org\/wiki\/Malabsorption\">malabsorption<\/a>,\u00a0<a title=\"Alcoholic liver disease\" href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholic_liver_disease\">alcoholic liver disease<\/a>, and several\u00a0<a title=\"Cancer\" href=\"https:\/\/en.wikipedia.org\/wiki\/Cancer\">cancers<\/a>. Damage to the\u00a0<a title=\"Central nervous system\" href=\"https:\/\/en.wikipedia.org\/wiki\/Central_nervous_system\">central nervous system<\/a>\u00a0and\u00a0<a title=\"Peripheral nervous system\" href=\"https:\/\/en.wikipedia.org\/wiki\/Peripheral_nervous_system\">peripheral nervous system<\/a>\u00a0can occur from sustained alcohol consumption.<sup id=\"cite_ref-36\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-36\">[36]<\/a><\/sup><sup id=\"cite_ref-37\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-37\">[37]<\/a><\/sup>\u00a0A wide range of immunologic defects can result and there may be a generalized skeletal fragility, in addition to a recognized tendency to accidental injury, resulting a propensity to bone fractures.<sup id=\"cite_ref-38\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-38\">[38]<\/a><\/sup>\r\n\r\nWomen develop long-term complications of alcohol dependence more rapidly than do men. Additionally, women have a higher mortality rate from alcoholism than men.<sup id=\"cite_ref-Blume_Laura_N.,_Nielson_Nancy_H.,_Riggs_Joseph_A.,_et_all_1998_861\u2013870_39-0\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-Blume_Laura_N.,_Nielson_Nancy_H.,_Riggs_Joseph_A.,_et_all_1998_861%E2%80%93870-39\">[39]<\/a><\/sup>\u00a0Examples of long-term complications include brain, heart, and liver damage<sup id=\"cite_ref-Walter_H.,_Gutierrez_K.,_Ramskogler_K.,_Hertling_I.,_Dvorak_A.,_Lesch_O.M.,_et_al._2003_253\u2013268_40-0\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-Walter_H.,_Gutierrez_K.,_Ramskogler_K.,_Hertling_I.,_Dvorak_A.,_Lesch_O.M.,_et_al._2003_253%E2%80%93268-40\">[40]<\/a><\/sup>\u00a0and an\u00a0<a title=\"Alcohol and breast cancer\" href=\"https:\/\/en.wikipedia.org\/wiki\/Alcohol_and_breast_cancer\">increased risk of breast cancer<\/a>. Additionally, heavy drinking over time has been found to have a negative effect on reproductive functioning in women. This results in reproductive dysfunction such as\u00a0<a title=\"Anovulation\" href=\"https:\/\/en.wikipedia.org\/wiki\/Anovulation\">anovulation<\/a>, decreased ovarian mass, problems or irregularity of the\u00a0<a title=\"Menstrual cycle\" href=\"https:\/\/en.wikipedia.org\/wiki\/Menstrual_cycle\">menstrual cycle<\/a>, and early\u00a0<a title=\"Menopause\" href=\"https:\/\/en.wikipedia.org\/wiki\/Menopause\">menopause<\/a>.<sup id=\"cite_ref-Blume_Laura_N.,_Nielson_Nancy_H.,_Riggs_Joseph_A.,_et_all_1998_861\u2013870_39-1\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-Blume_Laura_N.,_Nielson_Nancy_H.,_Riggs_Joseph_A.,_et_all_1998_861%E2%80%93870-39\">[39]<\/a><\/sup>\u00a0Alcoholic\u00a0<a title=\"Ketoacidosis\" href=\"https:\/\/en.wikipedia.org\/wiki\/Ketoacidosis\">ketoacidosis<\/a>\u00a0can occur in individuals who chronically misuse alcohol and have a recent history of\u00a0<a title=\"Binge drinking\" href=\"https:\/\/en.wikipedia.org\/wiki\/Binge_drinking\">binge drinking<\/a>.<sup id=\"cite_ref-Mihai-_41-0\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-Mihai--41\">[41]<\/a><\/sup><sup id=\"cite_ref-Siba\u00ef-2005_42-0\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-Siba%C3%AF-2005-42\">[42]<\/a><\/sup>\u00a0The amount of alcohol that can be biologically processed and its effects differ between sexes. Equal dosages of alcohol consumed by men and women generally result in women having higher\u00a0<a class=\"mw-redirect\" title=\"Blood alcohol concentration\" href=\"https:\/\/en.wikipedia.org\/wiki\/Blood_alcohol_concentration\">blood alcohol concentrations<\/a>\u00a0(BACs), since women generally have a lower weight and higher percentage of body fat and therefore a lower volume of distribution for alcohol than men.<sup id=\"cite_ref-pmid23101976_43-0\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-pmid23101976-43\">[43]<\/a><\/sup>\r\n<h4><span id=\"Psychiatric\" class=\"mw-headline\">Psychiatric<\/span><\/h4>\r\nLong-term misuse of alcohol can cause a wide range of\u00a0<a title=\"Mental health\" href=\"https:\/\/en.wikipedia.org\/wiki\/Mental_health\">mental health<\/a>\u00a0problems. Severe\u00a0<a class=\"mw-redirect\" title=\"Cognitive\" href=\"https:\/\/en.wikipedia.org\/wiki\/Cognitive\">cognitive<\/a>\u00a0problems are common; approximately 10 percent of all dementia cases are related to alcohol consumption, making it the second leading cause of\u00a0<a title=\"Dementia\" href=\"https:\/\/en.wikipedia.org\/wiki\/Dementia\">dementia<\/a>.<sup id=\"cite_ref-aamaibnc_44-0\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-aamaibnc-44\">[44]<\/a><\/sup>\u00a0Excessive alcohol use causes\u00a0<a title=\"Brain damage\" href=\"https:\/\/en.wikipedia.org\/wiki\/Brain_damage\">damage to brain function<\/a>, and psychological health can be increasingly affected over time.<sup id=\"cite_ref-45\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-45\">[45]<\/a><\/sup>\u00a0<a title=\"Social skills\" href=\"https:\/\/en.wikipedia.org\/wiki\/Social_skills\">Social skills<\/a>\u00a0are significantly impaired in people suffering from alcoholism due to the neurotoxic effects of alcohol on the brain, especially the\u00a0<a title=\"Prefrontal cortex\" href=\"https:\/\/en.wikipedia.org\/wiki\/Prefrontal_cortex\">prefrontal cortex<\/a>\u00a0area of the brain. The social skills that are impaired by alcohol use disorder include impairments in perceiving facial emotions,\u00a0<a title=\"Prosody (linguistics)\" href=\"https:\/\/en.wikipedia.org\/wiki\/Prosody_(linguistics)\">prosody<\/a>, perception problems, and\u00a0<a title=\"Theory of mind\" href=\"https:\/\/en.wikipedia.org\/wiki\/Theory_of_mind\">theory of mind<\/a>\u00a0deficits; the ability to understand humor is also impaired in people who misuse alcohol.<sup id=\"cite_ref-pmid18412750_46-0\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-pmid18412750-46\">[46]<\/a><\/sup>\u00a0Psychiatric disorders are common in alcoholics, with as many as 25 percent suffering severe psychiatric disturbances. The most prevalent psychiatric symptoms are\u00a0<a title=\"Anxiety disorder\" href=\"https:\/\/en.wikipedia.org\/wiki\/Anxiety_disorder\">anxiety<\/a>\u00a0and\u00a0<a title=\"Major depressive disorder\" href=\"https:\/\/en.wikipedia.org\/wiki\/Major_depressive_disorder\">depression<\/a>\u00a0disorders. Psychiatric symptoms usually initially worsen during alcohol withdrawal, but typically improve or disappear with continued abstinence.<sup id=\"cite_ref-47\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-47\">[47]<\/a><\/sup>\u00a0<a title=\"Psychosis\" href=\"https:\/\/en.wikipedia.org\/wiki\/Psychosis\">Psychosis<\/a>,\u00a0<a title=\"Confusion\" href=\"https:\/\/en.wikipedia.org\/wiki\/Confusion\">confusion<\/a>, and\u00a0<a title=\"Organic brain syndrome\" href=\"https:\/\/en.wikipedia.org\/wiki\/Organic_brain_syndrome\">organic brain syndrome<\/a>\u00a0may be caused by alcohol misuse, which can lead to a misdiagnosis such as\u00a0<a title=\"Schizophrenia\" href=\"https:\/\/en.wikipedia.org\/wiki\/Schizophrenia\">schizophrenia<\/a>.<sup id=\"cite_ref-48\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-48\">[48]<\/a><\/sup>\u00a0<a title=\"Panic disorder\" href=\"https:\/\/en.wikipedia.org\/wiki\/Panic_disorder\">Panic disorder<\/a>\u00a0can develop or worsen as a direct result of long-term alcohol misuse.<sup id=\"cite_ref-49\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-49\">[49]<\/a><\/sup><sup id=\"cite_ref-50\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-50\">[50]<\/a><\/sup>\r\n\r\nThe co-occurrence of\u00a0<a title=\"Major depressive disorder\" href=\"https:\/\/en.wikipedia.org\/wiki\/Major_depressive_disorder\">major depressive disorder<\/a>\u00a0and alcoholism is well documented.<sup id=\"cite_ref-51\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-51\">[51]<\/a><\/sup><sup id=\"cite_ref-52\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-52\">[52]<\/a><\/sup><sup id=\"cite_ref-53\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-53\">[53]<\/a><\/sup>\u00a0Among those with\u00a0<a class=\"mw-redirect\" title=\"Comorbid\" href=\"https:\/\/en.wikipedia.org\/wiki\/Comorbid\">comorbid<\/a>\u00a0occurrences, a distinction is commonly made between depressive episodes that remit with alcohol abstinence (\"substance-induced\"), and depressive episodes that are primary and do not remit with abstinence (\"independent\" episodes).<sup id=\"cite_ref-54\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-54\">[54]<\/a><\/sup><sup id=\"cite_ref-55\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-55\">[55]<\/a><\/sup><sup id=\"cite_ref-56\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-56\">[56]<\/a><\/sup>\u00a0Additional use of other drugs may increase the risk of depression.<sup id=\"cite_ref-57\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-57\">[57]<\/a><\/sup>\u00a0Psychiatric disorders differ depending on gender. Women who have alcohol-use disorders often have a co-occurring psychiatric diagnosis such as\u00a0<a class=\"mw-redirect\" title=\"Major depression\" href=\"https:\/\/en.wikipedia.org\/wiki\/Major_depression\">major depression<\/a>,\u00a0<a title=\"Anxiety\" href=\"https:\/\/en.wikipedia.org\/wiki\/Anxiety\">anxiety<\/a>,\u00a0<a title=\"Panic disorder\" href=\"https:\/\/en.wikipedia.org\/wiki\/Panic_disorder\">panic disorder<\/a>,\u00a0<a class=\"mw-redirect\" title=\"Bulimia\" href=\"https:\/\/en.wikipedia.org\/wiki\/Bulimia\">bulimia<\/a>,\u00a0<a title=\"Post-traumatic stress disorder\" href=\"https:\/\/en.wikipedia.org\/wiki\/Post-traumatic_stress_disorder\">post-traumatic stress disorder<\/a>\u00a0(PTSD), or\u00a0<a title=\"Borderline personality disorder\" href=\"https:\/\/en.wikipedia.org\/wiki\/Borderline_personality_disorder\">borderline personality disorder<\/a>. Men with alcohol-use disorders more often have a co-occurring diagnosis of\u00a0<a title=\"Narcissistic personality disorder\" href=\"https:\/\/en.wikipedia.org\/wiki\/Narcissistic_personality_disorder\">narcissistic<\/a>\u00a0or\u00a0<a title=\"Antisocial personality disorder\" href=\"https:\/\/en.wikipedia.org\/wiki\/Antisocial_personality_disorder\">antisocial personality disorder<\/a>,\u00a0<a title=\"Bipolar disorder\" href=\"https:\/\/en.wikipedia.org\/wiki\/Bipolar_disorder\">bipolar disorder<\/a>,\u00a0<a title=\"Schizophrenia\" href=\"https:\/\/en.wikipedia.org\/wiki\/Schizophrenia\">schizophrenia<\/a>,\u00a0<a class=\"mw-redirect\" title=\"Impulse disorder\" href=\"https:\/\/en.wikipedia.org\/wiki\/Impulse_disorder\">impulse disorders<\/a>\u00a0or\u00a0<a class=\"mw-redirect\" title=\"Attention deficit\/hyperactivity disorder\" href=\"https:\/\/en.wikipedia.org\/wiki\/Attention_deficit\/hyperactivity_disorder\">attention deficit\/hyperactivity disorder<\/a>\u00a0(ADHD).<sup id=\"cite_ref-Karrol_Brad_R._2002_337\u2013356_58-0\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-Karrol_Brad_R._2002_337%E2%80%93356-58\">[58]<\/a><\/sup>\u00a0Women with alcohol use disorder are more likely to experience physical or\u00a0<a title=\"Sexual assault\" href=\"https:\/\/en.wikipedia.org\/wiki\/Sexual_assault\">sexual assault<\/a>, abuse, and\u00a0<a title=\"Domestic violence\" href=\"https:\/\/en.wikipedia.org\/wiki\/Domestic_violence\">domestic violence<\/a>\u00a0than women in the general population,<sup id=\"cite_ref-Karrol_Brad_R._2002_337\u2013356_58-1\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-Karrol_Brad_R._2002_337%E2%80%93356-58\">[58]<\/a><\/sup>\u00a0which can lead to higher instances of psychiatric disorders and greater dependence on alcohol.\r\n<h4><span id=\"Social_effects\" class=\"mw-headline\">Social effects<\/span><\/h4>\r\n<div class=\"hatnote navigation-not-searchable\" role=\"note\">See also:\u00a0<a title=\"Drug-related crime\" href=\"https:\/\/en.wikipedia.org\/wiki\/Drug-related_crime\">Drug-related crime<\/a><\/div>\r\nSerious social problems arise from alcohol use disorder; these dilemmas are caused by the pathological changes in the brain and the intoxicating effects of alcohol.<sup id=\"cite_ref-aamaibnc_44-1\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-aamaibnc-44\">[44]<\/a><\/sup><sup id=\"cite_ref-Jessica_Kingsley_Publishers_59-0\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-Jessica_Kingsley_Publishers-59\">[59]<\/a><\/sup>\u00a0Alcohol misuse is associated with an increased risk of committing criminal offences, including\u00a0<a title=\"Child abuse\" href=\"https:\/\/en.wikipedia.org\/wiki\/Child_abuse\">child abuse<\/a>,\u00a0<a title=\"Domestic violence\" href=\"https:\/\/en.wikipedia.org\/wiki\/Domestic_violence\">domestic violence<\/a>,\u00a0<a title=\"Rape\" href=\"https:\/\/en.wikipedia.org\/wiki\/Rape\">rape<\/a>,\u00a0<a title=\"Burglary\" href=\"https:\/\/en.wikipedia.org\/wiki\/Burglary\">burglary<\/a>\u00a0and\u00a0<a title=\"Assault\" href=\"https:\/\/en.wikipedia.org\/wiki\/Assault\">assault<\/a>.<sup id=\"cite_ref-drug_use_a_reference_handbook_60-0\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-drug_use_a_reference_handbook-60\">[60]<\/a><\/sup>\u00a0Alcoholism is associated with\u00a0<a title=\"Termination of employment\" href=\"https:\/\/en.wikipedia.org\/wiki\/Termination_of_employment\">loss of employment<\/a>,<sup id=\"cite_ref-61\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-61\">[61]<\/a><\/sup>\u00a0which can lead to financial problems. Drinking at inappropriate times and behavior caused by reduced judgment can lead to legal consequences, such as criminal charges for\u00a0<a title=\"Drunk driving\" href=\"https:\/\/en.wikipedia.org\/wiki\/Drunk_driving\">drunk driving<\/a><sup id=\"cite_ref-abd2009_62-0\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-abd2009-62\">[62]<\/a><\/sup>\u00a0or public disorder, or civil penalties for\u00a0<a title=\"Tort\" href=\"https:\/\/en.wikipedia.org\/wiki\/Tort\">tortious<\/a>\u00a0behavior. An alcoholic's behavior and mental impairment while drunk can profoundly affect those surrounding him and lead to isolation from family and friends. This isolation can lead to\u00a0<a title=\"Relational disorder\" href=\"https:\/\/en.wikipedia.org\/wiki\/Relational_disorder\">marital conflict<\/a>\u00a0and\u00a0<a title=\"Divorce\" href=\"https:\/\/en.wikipedia.org\/wiki\/Divorce\">divorce<\/a>, or contribute to\u00a0<a title=\"Domestic violence\" href=\"https:\/\/en.wikipedia.org\/wiki\/Domestic_violence\">domestic violence<\/a>. Alcoholism can also lead to\u00a0<a title=\"Child neglect\" href=\"https:\/\/en.wikipedia.org\/wiki\/Child_neglect\">child neglect<\/a>, with subsequent lasting damage to the emotional development of the alcoholic's children.<sup id=\"cite_ref-tcemh2006_63-0\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-tcemh2006-63\">[63]<\/a><\/sup>\u00a0For this reason, children of alcoholic parents can develop a number of emotional problems. For example, they can become afraid of their parents, because of their unstable mood behaviors. In addition, they can develop considerable amount of shame over their inadequacy to liberate their parents from alcoholism. As a result of this failure, they develop wretched self-images, which can lead to depression.<sup id=\"cite_ref-64\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-64\">[64]<\/a><\/sup>\r\n<h3><span id=\"Alcohol_withdrawal\" class=\"mw-headline\">Alcohol withdrawal<\/span><\/h3>\r\n<div class=\"thumb tright\">\r\n<div class=\"thumbinner\">\r\n<div class=\"thumbcaption\"><span style=\"font-size: 1rem;text-align: initial\">As with similar substances with a sedative-hypnotic mechanism, such as\u00a0<\/span><a class=\"mw-redirect\" style=\"font-size: 1rem;text-align: initial\" title=\"Barbiturates\" href=\"https:\/\/en.wikipedia.org\/wiki\/Barbiturates\">barbiturates<\/a><span style=\"font-size: 1rem;text-align: initial\">\u00a0and\u00a0<\/span><a class=\"mw-redirect\" style=\"font-size: 1rem;text-align: initial\" title=\"Benzodiazepines\" href=\"https:\/\/en.wikipedia.org\/wiki\/Benzodiazepines\">benzodiazepines<\/a><span style=\"font-size: 1rem;text-align: initial\">, withdrawal from alcohol dependence can be fatal if it is not properly managed.<\/span><sup id=\"cite_ref-Jessica_Kingsley_Publishers_59-1\" class=\"reference\" style=\"text-align: initial\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-Jessica_Kingsley_Publishers-59\">[59]<\/a><\/sup><sup id=\"cite_ref-65\" class=\"reference\" style=\"text-align: initial\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-65\">[65]<\/a><\/sup><span style=\"font-size: 1rem;text-align: initial\">\u00a0Alcohol's primary effect is the increase in stimulation of the\u00a0<\/span><a style=\"font-size: 1rem;text-align: initial\" title=\"GABAA receptor\" href=\"https:\/\/en.wikipedia.org\/wiki\/GABAA_receptor\">GABA<sub>A<\/sub>\u00a0receptor<\/a><span style=\"font-size: 1rem;text-align: initial\">, promoting\u00a0<\/span><a style=\"font-size: 1rem;text-align: initial\" title=\"Central nervous system\" href=\"https:\/\/en.wikipedia.org\/wiki\/Central_nervous_system\">central nervous system<\/a><span style=\"font-size: 1rem;text-align: initial\">\u00a0depression. With repeated heavy consumption of alcohol, these receptors are desensitized and reduced in number, resulting in\u00a0<\/span><a style=\"font-size: 1rem;text-align: initial\" title=\"Drug tolerance\" href=\"https:\/\/en.wikipedia.org\/wiki\/Drug_tolerance\">tolerance<\/a><span style=\"font-size: 1rem;text-align: initial\">\u00a0and\u00a0<\/span><a style=\"font-size: 1rem;text-align: initial\" title=\"Physical dependence\" href=\"https:\/\/en.wikipedia.org\/wiki\/Physical_dependence\">physical dependence<\/a><span style=\"font-size: 1rem;text-align: initial\">. When alcohol consumption is stopped too abruptly, the person's nervous system suffers from uncontrolled\u00a0<\/span><a style=\"font-size: 1rem;text-align: initial\" title=\"Synapse\" href=\"https:\/\/en.wikipedia.org\/wiki\/Synapse\">synapse<\/a><span style=\"font-size: 1rem;text-align: initial\">\u00a0firing. This can result in symptoms that include\u00a0<\/span><a class=\"mw-redirect\" style=\"font-size: 1rem;text-align: initial\" title=\"Anxiety (mood)\" href=\"https:\/\/en.wikipedia.org\/wiki\/Anxiety_(mood)\">anxiety<\/a><span style=\"font-size: 1rem;text-align: initial\">, life-threatening\u00a0<\/span><a style=\"font-size: 1rem;text-align: initial\" title=\"Seizure\" href=\"https:\/\/en.wikipedia.org\/wiki\/Seizure\">seizures<\/a><span style=\"font-size: 1rem;text-align: initial\">,\u00a0<\/span><a style=\"font-size: 1rem;text-align: initial\" title=\"Delirium tremens\" href=\"https:\/\/en.wikipedia.org\/wiki\/Delirium_tremens\">delirium tremens<\/a><span style=\"font-size: 1rem;text-align: initial\">, hallucinations, shakes and possible\u00a0<\/span><a style=\"font-size: 1rem;text-align: initial\" title=\"Heart failure\" href=\"https:\/\/en.wikipedia.org\/wiki\/Heart_failure\">heart failure<\/a><span style=\"font-size: 1rem;text-align: initial\">.<\/span><sup id=\"cite_ref-Medical_toxicology_66-0\" class=\"reference\" style=\"text-align: initial\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-Medical_toxicology-66\">[66]<\/a><\/sup><sup id=\"cite_ref-67\" class=\"reference\" style=\"text-align: initial\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-67\">[67]<\/a><\/sup><span style=\"font-size: 1rem;text-align: initial\">\u00a0Other neurotransmitter systems are also involved, especially\u00a0<\/span><a style=\"font-size: 1rem;text-align: initial\" title=\"Dopamine\" href=\"https:\/\/en.wikipedia.org\/wiki\/Dopamine\">dopamine<\/a><span style=\"font-size: 1rem;text-align: initial\">,\u00a0<\/span><a class=\"mw-redirect\" style=\"font-size: 1rem;text-align: initial\" title=\"NMDA\" href=\"https:\/\/en.wikipedia.org\/wiki\/NMDA\">NMDA<\/a><span style=\"font-size: 1rem;text-align: initial\">\u00a0and\u00a0<\/span><a class=\"mw-redirect\" style=\"font-size: 1rem;text-align: initial\" title=\"Glutamate\" href=\"https:\/\/en.wikipedia.org\/wiki\/Glutamate\">glutamate<\/a><span style=\"font-size: 1rem;text-align: initial\">.<\/span><sup id=\"cite_ref-Hoffman-1996_29-1\" class=\"reference\" style=\"text-align: initial\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-Hoffman-1996-29\">[29]<\/a><\/sup><sup id=\"cite_ref-68\" class=\"reference\" style=\"text-align: initial\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-68\">[68]<\/a><\/sup><\/div>\r\n<\/div>\r\n<\/div>\r\nSevere acute withdrawal symptoms such as\u00a0<a title=\"Delirium tremens\" href=\"https:\/\/en.wikipedia.org\/wiki\/Delirium_tremens\">delirium tremens<\/a>\u00a0and seizures rarely occur after 1-week post cessation of alcohol. The acute withdrawal phase can be defined as lasting between one and three weeks. In the period of 3\u20136 weeks following cessation, anxiety, depression, fatigue, and sleep disturbance are common.<sup id=\"cite_ref-pmid20148778_69-0\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-pmid20148778-69\">[69]<\/a><\/sup>\u00a0Similar post-acute withdrawal symptoms have also been observed in animal models of alcohol dependence and withdrawal.<sup id=\"cite_ref-70\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-70\">[70]<\/a><\/sup>\r\n\r\nA\u00a0<a class=\"mw-redirect\" title=\"Kindling (sedative-hypnotic withdrawal)\" href=\"https:\/\/en.wikipedia.org\/wiki\/Kindling_(sedative-hypnotic_withdrawal)\">kindling effect<\/a>\u00a0also occurs in alcoholics whereby each subsequent withdrawal syndrome is more severe than the previous withdrawal episode; this is due to neuroadaptations which occur as a result of periods of abstinence followed by re-exposure to alcohol. Individuals who have had multiple withdrawal episodes are more likely to develop seizures and experience more severe anxiety during withdrawal from alcohol than alcohol-dependent individuals without a history of past alcohol withdrawal episodes. The kindling effect leads to persistent functional changes in brain neural circuits as well as to\u00a0<a title=\"Gene expression\" href=\"https:\/\/en.wikipedia.org\/wiki\/Gene_expression\">gene expression<\/a>.<sup id=\"cite_ref-Breese-2011_71-0\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-Breese-2011-71\">[71]<\/a><\/sup>\u00a0Kindling also results in the intensification of psychological symptoms of alcohol withdrawal.<sup id=\"cite_ref-pmid20148778_69-1\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-pmid20148778-69\">[69]<\/a><\/sup>\u00a0There are decision tools and questionnaires that help guide physicians in evaluating alcohol withdrawal. For example, the CIWA-Ar objectifies alcohol withdrawal symptoms in order to guide therapy decisions which allows for an efficient interview while at the same time retaining clinical usefulness, validity, and reliability, ensuring proper care for withdrawal patients, who can be in danger of death.<sup id=\"cite_ref-72\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-72\">[72]<\/a><\/sup>\r\n<h2><span id=\"Causes\" class=\"mw-headline\">Causes<\/span><\/h2>\r\n<div class=\"thumb tright\">\r\n<div class=\"thumbinner\">\r\n\r\n<a class=\"image\" href=\"https:\/\/en.wikipedia.org\/wiki\/File:William_Hogarth_-_Gin_Lane.jpg\"><img class=\"thumbimage alignleft\" src=\"https:\/\/upload.wikimedia.org\/wikipedia\/commons\/thumb\/d\/d0\/William_Hogarth_-_Gin_Lane.jpg\/220px-William_Hogarth_-_Gin_Lane.jpg\" alt=\"\" width=\"220\" height=\"255\" \/><\/a>\r\n<div class=\"thumbcaption\">\r\n<div class=\"magnify\"><span style=\"font-size: 1rem;text-align: initial\">A complex combination of genetic and environmental factors influences the risk of the development of alcoholism. Drinking excessive alcohol during childhood or adolescence, is a risk factor, or to have low autoestime, thus to be someone with antisocial, addictive or wrathful behaviour, so as also minimize or naturalize so much alcohol misuse,\u00a0<\/span><a style=\"font-size: 1rem;text-align: initial\" title=\"Alcohol dependence\" href=\"https:\/\/en.wikipedia.org\/wiki\/Alcohol_dependence\">alcohol dependence<\/a><span style=\"font-size: 1rem;text-align: initial\">\u00a0and the\u00a0<\/span><a style=\"font-size: 1rem;text-align: initial\" title=\"Long-term effects of alcohol\" href=\"https:\/\/en.wikipedia.org\/wiki\/Long-term_effects_of_alcohol\">long-term effects of alcohol<\/a><span style=\"font-size: 1rem;text-align: initial\">\u00a0or also the\u00a0<\/span><a style=\"font-size: 1rem;text-align: initial\" title=\"Short-term effects of alcohol consumption\" href=\"https:\/\/en.wikipedia.org\/wiki\/Short-term_effects_of_alcohol_consumption\">short-term effects of alcohol consumption<\/a><span style=\"font-size: 1rem;text-align: initial\">\u00a0in the human body, is very known that some people depending of their life perspective or outlook can have more or less probabilities of to have drinking problems\u00a0<\/span><sup id=\"cite_ref-Enoch-2006_73-0\" class=\"reference\" style=\"text-align: initial\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-Enoch-2006-73\">[73]<\/a><\/sup><span style=\"font-size: 1rem;text-align: initial\">\u00a0Genes that influence the metabolism of alcohol also influence the risk of alcoholism, as can a family history of alcoholism.<\/span><sup id=\"cite_ref-Edenberg_2281\u20132297_74-0\" class=\"reference\" style=\"text-align: initial\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-Edenberg_2281%E2%80%932297-74\">[74]<\/a><\/sup><span style=\"font-size: 1rem;text-align: initial\">\u00a0There is compelling evidence that alcohol use at an early age may influence the\u00a0<\/span><a style=\"font-size: 1rem;text-align: initial\" title=\"Gene expression\" href=\"https:\/\/en.wikipedia.org\/wiki\/Gene_expression\">expression of genes<\/a><span style=\"font-size: 1rem;text-align: initial\">\u00a0which increase the risk of alcohol dependence. These genetic and\u00a0<\/span><a style=\"font-size: 1rem;text-align: initial\" title=\"Epigenetics\" href=\"https:\/\/en.wikipedia.org\/wiki\/Epigenetics\">epigenetic<\/a><span style=\"font-size: 1rem;text-align: initial\">\u00a0results are regarded as consistent with large longitudinal population studies finding that the younger the age of drinking onset, the greater the prevalence of lifetime alcohol dependence.<\/span><sup id=\"cite_ref-75\" class=\"reference\" style=\"text-align: initial\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-75\">[75]<\/a><\/sup><sup id=\"cite_ref-pmid27677720_76-0\" class=\"reference\" style=\"text-align: initial\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-pmid27677720-76\">[76]<\/a><\/sup><\/div>\r\n<\/div>\r\n<\/div>\r\n<\/div>\r\n<a title=\"Psychological trauma\" href=\"https:\/\/en.wikipedia.org\/wiki\/Psychological_trauma\">Severe childhood trauma<\/a>\u00a0is also associated with a general increase in the risk of drug dependency.<sup id=\"cite_ref-Enoch-2006_73-1\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-Enoch-2006-73\">[73]<\/a><\/sup>\u00a0Lack of peer and family support is associated with an increased risk of alcoholism developing.<sup id=\"cite_ref-Enoch-2006_73-2\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-Enoch-2006-73\">[73]<\/a><\/sup>\u00a0Genetics and adolescence are associated with an increased sensitivity to the neurotoxic effects of chronic alcohol use.\u00a0<a title=\"Cerebral cortex\" href=\"https:\/\/en.wikipedia.org\/wiki\/Cerebral_cortex\">Cortical<\/a>\u00a0degeneration due to the neurotoxic effects increases impulsive behaviour, which may contribute to the development, persistence and severity of alcohol use disorders. There is evidence that with abstinence, there is a reversal of at least some of the alcohol induced central nervous system damage.<sup id=\"cite_ref-Crews-2009_77-0\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-Crews-2009-77\">[77]<\/a><\/sup>\u00a0The use of cannabis was associated with later problems with alcohol use.<sup id=\"cite_ref-PMID26875671_78-0\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-PMID26875671-78\">[78]<\/a><\/sup>\u00a0Alcohol use was associated with an increased probability of later use of tobacco and illegal drugs such as cannabis.<sup id=\"cite_ref-PMID22712674_79-0\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-PMID22712674-79\">[79]<\/a><\/sup>\r\n<h3><span id=\"Screening\" class=\"mw-headline\">Screening<\/span><\/h3>\r\nScreening is recommended among those over the age of 18.<sup id=\"cite_ref-111\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-111\">[111]<\/a><\/sup>\u00a0Several tools may be used to detect a loss of control of alcohol use. These tools are mostly\u00a0<a class=\"mw-redirect\" title=\"Self report study\" href=\"https:\/\/en.wikipedia.org\/wiki\/Self_report_study\">self-reports<\/a>\u00a0in questionnaire form. Another common theme is a score or tally that sums up the general severity of alcohol use.<sup id=\"cite_ref-Kahan-1996_112-0\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-Kahan-1996-112\">[112]<\/a><\/sup>\r\n<div class=\"textbox\">\r\n\r\nThe\u00a0<a title=\"CAGE questionnaire\" href=\"https:\/\/en.wikipedia.org\/wiki\/CAGE_questionnaire\">CAGE questionnaire<\/a>, named for its four questions, is one such example that may be used to screen patients quickly in a doctor's office.\r\n<blockquote class=\"templatequote\">Two \"yes\" responses indicate that the respondent should be investigated further.\r\n\r\nThe questionnaire asks the following questions:\r\n<ol>\r\n \t<li>Have you ever felt you needed to\u00a0<b>C<\/b>ut down on your drinking?<\/li>\r\n \t<li>Have people\u00a0<b>A<\/b>nnoyed you by criticizing your drinking?<\/li>\r\n \t<li>Have you ever felt\u00a0<b>G<\/b>uilty about drinking?<\/li>\r\n \t<li>Have you ever felt you needed a drink first thing in the morning (<b>E<\/b>ye-opener) to steady your nerves or to get rid of a hangover?<sup id=\"cite_ref-113\" class=\"reference\"><\/sup><\/li>\r\n<\/ol>\r\n<\/blockquote>\r\n<dl>\r\n \t<dd>The CAGE questionnaire has demonstrated a high effectiveness in detecting alcohol-related problems; however, it has limitations in people with less severe alcohol-related problems, white women and college students.<sup id=\"cite_ref-115\" class=\"reference\"><\/sup><\/dd>\r\n<\/dl>\r\n<\/div>\r\n<dl><\/dl>\r\nOther tests are sometimes used for the detection of alcohol dependence, such as the\u00a0<a title=\"Alcohol Dependence Data Questionnaire\" href=\"https:\/\/en.wikipedia.org\/wiki\/Alcohol_Dependence_Data_Questionnaire\">Alcohol Dependence Data Questionnaire<\/a>, which is a more sensitive diagnostic test than the\u00a0<a title=\"CAGE questionnaire\" href=\"https:\/\/en.wikipedia.org\/wiki\/CAGE_questionnaire\">CAGE questionnaire<\/a>. It helps distinguish a diagnosis of alcohol dependence from one of heavy alcohol use.<sup id=\"cite_ref-116\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-116\">[116]<\/a><\/sup>\u00a0The\u00a0<a class=\"mw-redirect\" title=\"Michigan Alcohol Screening Test\" href=\"https:\/\/en.wikipedia.org\/wiki\/Michigan_Alcohol_Screening_Test\">Michigan Alcohol Screening Test<\/a>\u00a0(MAST) is a screening tool for alcoholism widely used by courts to determine the appropriate sentencing for people convicted of alcohol-related offenses,<sup id=\"cite_ref-117\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-117\">[117]<\/a><\/sup>\u00a0<a title=\"Driving under the influence\" href=\"https:\/\/en.wikipedia.org\/wiki\/Driving_under_the_influence\">driving under the influence<\/a>\u00a0being the most common. The\u00a0<a title=\"Alcohol Use Disorders Identification Test\" href=\"https:\/\/en.wikipedia.org\/wiki\/Alcohol_Use_Disorders_Identification_Test\">Alcohol Use Disorders Identification Test<\/a>\u00a0(AUDIT), a screening questionnaire developed by the\u00a0<a title=\"World Health Organization\" href=\"https:\/\/en.wikipedia.org\/wiki\/World_Health_Organization\">World Health Organization<\/a>, is unique in that it has been validated in six countries and is used internationally. Like the CAGE questionnaire, it uses a simple set of questions \u2013 a high score earning a deeper investigation.<sup id=\"cite_ref-118\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-118\">[118]<\/a><\/sup>\u00a0The\u00a0<a class=\"mw-redirect\" title=\"Paddington Alcohol Test\" href=\"https:\/\/en.wikipedia.org\/wiki\/Paddington_Alcohol_Test\">Paddington Alcohol Test<\/a>\u00a0(PAT) was designed to screen for alcohol-related problems amongst those attending\u00a0<a class=\"mw-redirect\" title=\"Accident and Emergency department\" href=\"https:\/\/en.wikipedia.org\/wiki\/Accident_and_Emergency_department\">Accident and Emergency departments<\/a>. It concords well with the AUDIT questionnaire but is administered in a fifth of the time.<sup id=\"cite_ref-119\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-119\">[119]<\/a><\/sup>\r\n<h2><span id=\"Management\" class=\"mw-headline\">Management<\/span><\/h2>\r\nTreatments are varied because there are multiple perspectives of alcoholism. Those who approach alcoholism as a medical condition or disease recommend differing treatments from, for instance, those who approach the condition as one of social choice. Most treatments focus on helping people discontinue their alcohol intake, followed up with life training and\/or social support to help them resist a return to alcohol use. Since alcoholism involves multiple factors which encourage a person to continue drinking, they must all be addressed to successfully prevent a relapse. An example of this kind of treatment is detoxification followed by a combination of supportive therapy, attendance at self-help groups, and ongoing development of coping mechanisms. Much of the treatment community for alcoholism supports an abstinence-based\u00a0<a title=\"Zero tolerance\" href=\"https:\/\/en.wikipedia.org\/wiki\/Zero_tolerance\">zero tolerance<\/a>\u00a0approach; however, some prefer a\u00a0<a title=\"Harm reduction\" href=\"https:\/\/en.wikipedia.org\/wiki\/Harm_reduction\">harm-reduction<\/a>\u00a0approach.<sup id=\"cite_ref-Gabbard_125-0\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-Gabbard-125\">[125]<\/a><\/sup>\r\n<h3><span id=\"Detoxification\" class=\"mw-headline\">Detoxification<\/span><\/h3>\r\n<div class=\"hatnote navigation-not-searchable\" role=\"note\">Main article:\u00a0<a title=\"Alcohol detoxification\" href=\"https:\/\/en.wikipedia.org\/wiki\/Alcohol_detoxification\">Alcohol detoxification<\/a><\/div>\r\n<a title=\"Alcohol detoxification\" href=\"https:\/\/en.wikipedia.org\/wiki\/Alcohol_detoxification\">Alcohol detoxification<\/a>\u00a0or 'detox' for alcoholics is an abrupt stop of alcohol drinking coupled with the substitution of drugs, such as\u00a0<a class=\"mw-redirect\" title=\"Benzodiazepines\" href=\"https:\/\/en.wikipedia.org\/wiki\/Benzodiazepines\">benzodiazepines<\/a>, that have similar effects to prevent\u00a0<a title=\"Alcohol withdrawal syndrome\" href=\"https:\/\/en.wikipedia.org\/wiki\/Alcohol_withdrawal_syndrome\">alcohol withdrawal<\/a>. Individuals who are only at risk of mild to moderate withdrawal symptoms can be detoxified as outpatients. Individuals at risk of a severe withdrawal syndrome as well as those who have significant or acute comorbid conditions are generally treated as inpatients. Detoxification does not actually treat alcoholism, and it is necessary to follow up detoxification with an appropriate treatment program for alcohol dependence or alcohol use disorder to reduce the risk of relapse.<sup id=\"cite_ref-Blondell-2005_9-5\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-Blondell-2005-9\">[9]<\/a><\/sup>\u00a0Some symptoms of alcohol withdrawal such as depressed mood and anxiety typically take weeks or months to abate while other symptoms persist longer due to persisting neuroadaptations.<sup id=\"cite_ref-pmid20148778_69-2\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-pmid20148778-69\">[69]<\/a><\/sup>\u00a0Alcoholism has serious adverse effects on brain function; on average it takes one year of abstinence to recover from the cognitive deficits incurred by chronic alcohol misuse.<sup id=\"cite_ref-Stavro-2012_126-0\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-Stavro-2012-126\">[126]<\/a><\/sup>\r\n<h3><span id=\"Psychological\" class=\"mw-headline\">Psychological<\/span><\/h3>\r\n<div class=\"thumb tright\">\r\n<div class=\"thumbinner\">\r\n\r\n[caption id=\"\" align=\"alignleft\" width=\"220\"]<a class=\"image\" href=\"https:\/\/en.wikipedia.org\/wiki\/File:Alcoholics_Anonymous_Regional_Service_Center_by_David_Shankbone.jpg\"><img class=\"thumbimage\" src=\"https:\/\/upload.wikimedia.org\/wikipedia\/commons\/thumb\/3\/30\/Alcoholics_Anonymous_Regional_Service_Center_by_David_Shankbone.jpg\/220px-Alcoholics_Anonymous_Regional_Service_Center_by_David_Shankbone.jpg\" alt=\"\" width=\"220\" height=\"165\" \/><\/a> A regional service center for\u00a0Alcoholics Anonymous.[\/caption]\r\n\r\n<div class=\"thumbcaption\">\r\n<div class=\"magnify\"><span style=\"font-size: 1rem;text-align: initial\">Various forms of\u00a0<\/span><a class=\"mw-redirect\" style=\"font-size: 1rem;text-align: initial\" title=\"Group therapy\" href=\"https:\/\/en.wikipedia.org\/wiki\/Group_therapy\">group therapy<\/a><span style=\"font-size: 1rem;text-align: initial\">\u00a0or\u00a0<\/span><a style=\"font-size: 1rem;text-align: initial\" title=\"Psychotherapy\" href=\"https:\/\/en.wikipedia.org\/wiki\/Psychotherapy\">psychotherapy<\/a><span style=\"font-size: 1rem;text-align: initial\">\u00a0can be used to deal with underlying psychological issues that are related to alcohol addiction, as well as provide relapse prevention skills. The mutual-help group-counseling approach is one of the most common ways of helping alcoholics maintain sobriety.<\/span><sup id=\"cite_ref-Morgan-Lopez-2006_8-2\" class=\"reference\" style=\"text-align: initial\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-Morgan-Lopez-2006-8\">[8]<\/a><\/sup><span style=\"font-size: 1rem;text-align: initial\">\u00a0<\/span><a style=\"font-size: 1rem;text-align: initial\" title=\"Alcoholics Anonymous\" href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholics_Anonymous\">Alcoholics Anonymous<\/a><span style=\"font-size: 1rem;text-align: initial\">\u00a0was one of the first organizations formed to provide mutual, nonprofessional counseling, and it is still the largest. Others include\u00a0<\/span><a style=\"font-size: 1rem;text-align: initial\" title=\"LifeRing Secular Recovery\" href=\"https:\/\/en.wikipedia.org\/wiki\/LifeRing_Secular_Recovery\">LifeRing Secular Recovery<\/a><span style=\"font-size: 1rem;text-align: initial\">,\u00a0<\/span><a style=\"font-size: 1rem;text-align: initial\" title=\"SMART Recovery\" href=\"https:\/\/en.wikipedia.org\/wiki\/SMART_Recovery\">SMART Recovery<\/a><span style=\"font-size: 1rem;text-align: initial\">,\u00a0<\/span><a style=\"font-size: 1rem;text-align: initial\" title=\"Women for Sobriety\" href=\"https:\/\/en.wikipedia.org\/wiki\/Women_for_Sobriety\">Women for Sobriety<\/a><span style=\"font-size: 1rem;text-align: initial\">, and\u00a0<\/span><a style=\"font-size: 1rem;text-align: initial\" title=\"Secular Organizations for Sobriety\" href=\"https:\/\/en.wikipedia.org\/wiki\/Secular_Organizations_for_Sobriety\">Secular Organizations for Sobriety<\/a><span style=\"font-size: 1rem;text-align: initial\">.<\/span><sup id=\"cite_ref-127\" class=\"reference\" style=\"text-align: initial\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-127\">[127]<\/a><\/sup><span style=\"font-size: 1rem;text-align: initial\">\u00a0Alcoholics Anonymous and\u00a0<\/span><a style=\"font-size: 1rem;text-align: initial\" title=\"Twelve-step program\" href=\"https:\/\/en.wikipedia.org\/wiki\/Twelve-step_program\">twelve-step programs<\/a><span style=\"font-size: 1rem;text-align: initial\">\u00a0appear more effective than cognitive behavioral therapy or abstinence.<\/span><sup id=\"cite_ref-coch2020_128-0\" class=\"reference\" style=\"text-align: initial\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-coch2020-128\">[128]<\/a><\/sup><\/div>\r\n<\/div>\r\n<\/div>\r\n<\/div>\r\n<h3><\/h3>\r\n<h3><span id=\"Moderate_drinking\" class=\"mw-headline\">Moderate drinking<\/span><\/h3>\r\nRationing and moderation programs such as\u00a0<a title=\"Moderation Management\" href=\"https:\/\/en.wikipedia.org\/wiki\/Moderation_Management\">Moderation Management<\/a>\u00a0and DrinkWise do not mandate complete abstinence. While most alcoholics are unable to limit their drinking in this way, some return to moderate drinking. A 2002 US study by the\u00a0<a title=\"National Institute on Alcohol Abuse and Alcoholism\" href=\"https:\/\/en.wikipedia.org\/wiki\/National_Institute_on_Alcohol_Abuse_and_Alcoholism\">National Institute on Alcohol Abuse and Alcoholism<\/a>\u00a0(NIAAA) showed that 17.7 percent of individuals diagnosed as alcohol dependent more than one year prior returned to low-risk drinking. This group, however, showed fewer initial symptoms of dependency.<sup id=\"cite_ref-DAWSON2005_129-0\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-DAWSON2005-129\">[129]<\/a><\/sup>\r\n\r\nA follow-up study, using the same subjects that were judged to be in remission in 2001\u20132002, examined the rates of return to problem drinking in 2004\u20132005. The study found abstinence from alcohol was the most stable form of remission for recovering alcoholics.<sup id=\"cite_ref-DAWSON2007_130-0\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-DAWSON2007-130\">[130]<\/a><\/sup>\u00a0There was also a 1973 study showing chronic alcoholics drinking moderately again,<sup id=\"cite_ref-Sobell1973_131-0\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-Sobell1973-131\">[131]<\/a><\/sup>\u00a0but a 1982 follow-up showed that 95% of subjects were not able to moderately drink over the long term.<sup id=\"cite_ref-Pendery1982_132-0\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-Pendery1982-132\">[132]<\/a><\/sup><sup id=\"cite_ref-Pendery1982NYT_133-0\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-Pendery1982NYT-133\">[133]<\/a><\/sup>\u00a0Another study was a long-term (60 year) follow-up of two groups of alcoholic men which concluded that \"return to controlled drinking rarely persisted for much more than a decade without relapse or evolution into abstinence.\"<sup id=\"cite_ref-VAILLANT2003_134-0\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-VAILLANT2003-134\">[134]<\/a><\/sup>\u00a0Internet based measures appear to be useful at least in the short term.<sup id=\"cite_ref-135\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-135\">[135]<\/a><\/sup>\r\n<h3><span id=\"Medications\" class=\"mw-headline\">Medications<\/span><\/h3>\r\n<h2><span id=\"Disulfiram-like_drug\" class=\"mw-headline\"><a title=\"Disulfiram-like drug\" href=\"https:\/\/en.wikipedia.org\/wiki\/Disulfiram-like_drug\">Disulfiram-like drug<\/a><\/span><\/h2>\r\nIn the United States there are four approved medications for alcoholism: acamprosate, two methods of using naltrexone and disulfiram.<sup id=\"cite_ref-136\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-136\">[136]<\/a><\/sup>\r\n<ul>\r\n \t<li><a title=\"Acamprosate\" href=\"https:\/\/en.wikipedia.org\/wiki\/Acamprosate\">Acamprosate<\/a>\u00a0may stabilise the brain chemistry that is altered due to alcohol dependence via antagonising the actions of\u00a0<a class=\"mw-redirect\" title=\"Glutamate\" href=\"https:\/\/en.wikipedia.org\/wiki\/Glutamate\">glutamate<\/a>, a neurotransmitter which is hyperactive in the\u00a0<a class=\"mw-redirect\" title=\"Post-withdrawal\" href=\"https:\/\/en.wikipedia.org\/wiki\/Post-withdrawal\">post-withdrawal<\/a>\u00a0phase.<sup id=\"cite_ref-137\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-137\">[137]<\/a><\/sup>\u00a0By reducing excessive NMDA activity which occurs at the onset of alcohol withdrawal, acamprosate can reduce or prevent alcohol withdrawal related neurotoxicity.<sup id=\"cite_ref-pmid20201812_138-0\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-pmid20201812-138\">[138]<\/a><\/sup>\u00a0Acamprosate reduces the risk of relapse amongst alcohol-dependent persons.<sup id=\"cite_ref-139\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-139\">[139]<\/a><\/sup><sup id=\"cite_ref-JAMA2014_140-0\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-JAMA2014-140\">[140]<\/a><\/sup><\/li>\r\n \t<li><a title=\"Naltrexone\" href=\"https:\/\/en.wikipedia.org\/wiki\/Naltrexone\">Naltrexone<\/a>\u00a0is a\u00a0<a class=\"mw-redirect\" title=\"Competitive antagonist\" href=\"https:\/\/en.wikipedia.org\/wiki\/Competitive_antagonist\">competitive antagonist<\/a>\u00a0for opioid receptors, effectively blocking the effects of\u00a0<a class=\"mw-redirect\" title=\"Endorphin\" href=\"https:\/\/en.wikipedia.org\/wiki\/Endorphin\">endorphins<\/a>\u00a0and\u00a0<a title=\"Opioid\" href=\"https:\/\/en.wikipedia.org\/wiki\/Opioid\">opioids<\/a>. Naltrexone is used to decrease cravings for alcohol and encourage abstinence. Alcohol causes the body to release endorphins, which in turn release dopamine and activate the reward pathways; hence in the body reduces the pleasurable effects from consuming alcohol.<sup id=\"cite_ref-141\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-141\">[141]<\/a><\/sup>\u00a0Evidence supports a reduced risk of relapse among alcohol-dependent persons and a decrease in excessive drinking.<sup id=\"cite_ref-JAMA2014_140-1\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-JAMA2014-140\">[140]<\/a><\/sup>\u00a0<a title=\"Nalmefene\" href=\"https:\/\/en.wikipedia.org\/wiki\/Nalmefene\">Nalmefene<\/a>\u00a0also appears effective and works in a similar manner.<sup id=\"cite_ref-JAMA2014_140-2\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-JAMA2014-140\">[140]<\/a><\/sup><\/li>\r\n \t<li><span id=\"The_Sinclair_Method\" class=\"anchor\"><\/span>The Sinclair method is another approach to using naltrexone or other\u00a0<a title=\"Opioid antagonist\" href=\"https:\/\/en.wikipedia.org\/wiki\/Opioid_antagonist\">opioid antagonists<\/a>\u00a0to treat alcoholism by having the person take the medication about an hour before they drink alcohol\u00a0<i>and only then<\/i>.<sup id=\"cite_ref-142\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-142\">[142]<\/a><\/sup><sup id=\"cite_ref-Sin2001_143-0\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-Sin2001-143\">[143]<\/a><\/sup>\u00a0The medication blocks the\u00a0<a class=\"mw-redirect\" title=\"Positive reinforcement\" href=\"https:\/\/en.wikipedia.org\/wiki\/Positive_reinforcement\">positive reinforcement<\/a>\u00a0effects of ethanol and hypothetically allows the person to stop drinking or drink less.<sup id=\"cite_ref-Sin2001_143-1\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-Sin2001-143\">[143]<\/a><\/sup><\/li>\r\n \t<li><a title=\"Disulfiram\" href=\"https:\/\/en.wikipedia.org\/wiki\/Disulfiram\">Disulfiram<\/a>\u00a0prevents the elimination of\u00a0<a title=\"Acetaldehyde\" href=\"https:\/\/en.wikipedia.org\/wiki\/Acetaldehyde\">acetaldehyde<\/a>, a chemical the body produces when breaking down ethanol. Acetaldehyde itself is the cause of many\u00a0<a title=\"Hangover\" href=\"https:\/\/en.wikipedia.org\/wiki\/Hangover\">hangover<\/a>\u00a0symptoms from alcohol use. The overall effect is discomfort when alcohol is ingested: an extremely fast-acting and long-lasting, uncomfortable hangover.<\/li>\r\n<\/ul>\r\nSeveral other drugs are also used and many are under investigation.\r\n<ul>\r\n \t<li><a class=\"mw-redirect\" title=\"Benzodiazepines\" href=\"https:\/\/en.wikipedia.org\/wiki\/Benzodiazepines\">Benzodiazepines<\/a>, while useful in the management of acute alcohol withdrawal, if used long-term can cause a worse outcome in alcoholism. Alcoholics on chronic benzodiazepines have a lower rate of achieving abstinence from alcohol than those not taking benzodiazepines. This class of drugs is commonly prescribed to alcoholics for insomnia or anxiety management.<sup id=\"cite_ref-144\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-144\">[144]<\/a><\/sup>\u00a0Initiating prescriptions of benzodiazepines or sedative-hypnotics in individuals in recovery has a high rate of relapse with one author reporting more than a quarter of people relapsed after being prescribed sedative-hypnotics. Those who are long-term users of benzodiazepines should not be withdrawn rapidly, as severe anxiety and panic may develop, which are known risk factors for alcohol use disorder relapse. Taper regimes of 6\u201312 months have been found to be the most successful, with reduced intensity of withdrawal.<sup id=\"cite_ref-145\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-145\">[145]<\/a><\/sup><sup id=\"cite_ref-146\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-146\">[146]<\/a><\/sup><\/li>\r\n \t<li><a title=\"Calcium carbimide\" href=\"https:\/\/en.wikipedia.org\/wiki\/Calcium_carbimide\">Calcium carbimide<\/a>\u00a0works in the same way as disulfiram; it has an advantage in that the occasional adverse effects of disulfiram,\u00a0<a title=\"Hepatotoxicity\" href=\"https:\/\/en.wikipedia.org\/wiki\/Hepatotoxicity\">hepatotoxicity<\/a>\u00a0and drowsiness, do not occur with calcium carbimide.<sup id=\"cite_ref-147\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-147\">[147]<\/a><\/sup><\/li>\r\n \t<li><a title=\"Ondansetron\" href=\"https:\/\/en.wikipedia.org\/wiki\/Ondansetron\">Ondansetron<\/a>\u00a0and\u00a0<a title=\"Topiramate\" href=\"https:\/\/en.wikipedia.org\/wiki\/Topiramate\">topiramate<\/a>\u00a0are supported by tentative evidence in people with certain genetics.<sup id=\"cite_ref-Soy2017_148-0\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-Soy2017-148\">[148]<\/a><\/sup><sup id=\"cite_ref-Cs2017_149-0\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-Cs2017-149\">[149]<\/a><\/sup>\u00a0Evidence for ondansetron is more in those who have just begun having problems with alcohol.<sup id=\"cite_ref-Soy2017_148-1\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-Soy2017-148\">[148]<\/a><\/sup>\u00a0Topiramate is a derivative of the naturally occurring sugar monosaccharide D-fructose. Review articles characterize topiramate as showing \"encouraging\",<sup id=\"cite_ref-Soy2017_148-2\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-Soy2017-148\">[148]<\/a><\/sup>\u00a0\"promising\",<sup id=\"cite_ref-Soy2017_148-3\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-Soy2017-148\">[148]<\/a><\/sup>\u00a0\"efficacious\",<sup id=\"cite_ref-150\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-150\">[150]<\/a><\/sup>\u00a0and \"insufficient\"<sup id=\"cite_ref-151\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-151\">[151]<\/a><\/sup>\u00a0evidence in the treatment of alcohol use disorders.<\/li>\r\n<\/ul>\r\nEvidence does not support the use of\u00a0<a class=\"mw-redirect\" title=\"Selective serotonin reuptake inhibitors\" href=\"https:\/\/en.wikipedia.org\/wiki\/Selective_serotonin_reuptake_inhibitors\">selective serotonin reuptake inhibitors<\/a>\u00a0(SSRIs),\u00a0<a class=\"mw-redirect\" title=\"Tricyclic antidepressants\" href=\"https:\/\/en.wikipedia.org\/wiki\/Tricyclic_antidepressants\">tricyclic antidepressants<\/a>\u00a0(TCAs),\u00a0<a title=\"Antipsychotic\" href=\"https:\/\/en.wikipedia.org\/wiki\/Antipsychotic\">antipsychotics<\/a>, or\u00a0<a title=\"Gabapentin\" href=\"https:\/\/en.wikipedia.org\/wiki\/Gabapentin\">gabapentin<\/a>.<sup id=\"cite_ref-JAMA2014_140-3\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-JAMA2014-140\">[140]<\/a><\/sup>\r\n<h3><span id=\"Dual_addictions_and_dependences\" class=\"mw-headline\">Dual addictions and dependences<\/span><\/h3>\r\nAlcoholics may also require treatment for other psychotropic\u00a0<a class=\"mw-redirect\" title=\"Drug addiction\" href=\"https:\/\/en.wikipedia.org\/wiki\/Drug_addiction\">drug addictions<\/a>\u00a0and\u00a0<a class=\"mw-redirect\" title=\"Drug dependence\" href=\"https:\/\/en.wikipedia.org\/wiki\/Drug_dependence\">drug dependences<\/a>. The most common dual dependence syndrome with alcohol dependence is\u00a0<a title=\"Benzodiazepine dependence\" href=\"https:\/\/en.wikipedia.org\/wiki\/Benzodiazepine_dependence\">benzodiazepine dependence<\/a>, with studies showing 10\u201320 percent of alcohol-dependent individuals had problems of dependence and\/or misuse problems of benzodiazepine drugs such as\u00a0<a title=\"Diazepam\" href=\"https:\/\/en.wikipedia.org\/wiki\/Diazepam\">diazepam<\/a>\u00a0or\u00a0<a title=\"Clonazepam\" href=\"https:\/\/en.wikipedia.org\/wiki\/Clonazepam\">clonazepam<\/a>. These drugs are, like alcohol,\u00a0<a title=\"Depressant\" href=\"https:\/\/en.wikipedia.org\/wiki\/Depressant\">depressants<\/a>. Benzodiazepines may be used legally, if they are prescribed by doctors for anxiety problems or other mood disorders, or they may be purchased as\u00a0<a class=\"mw-redirect\" title=\"Illegal drugs\" href=\"https:\/\/en.wikipedia.org\/wiki\/Illegal_drugs\">illegal drugs<\/a>. Benzodiazepine use increases cravings for alcohol and the volume of alcohol consumed by problem drinkers.<sup id=\"cite_ref-152\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-152\">[152]<\/a><\/sup>\u00a0Benzodiazepine dependency requires careful reduction in dosage to avoid\u00a0<a title=\"Benzodiazepine withdrawal syndrome\" href=\"https:\/\/en.wikipedia.org\/wiki\/Benzodiazepine_withdrawal_syndrome\">benzodiazepine withdrawal syndrome<\/a>\u00a0and other health consequences. Dependence on other sedative-hypnotics such as\u00a0<a title=\"Zolpidem\" href=\"https:\/\/en.wikipedia.org\/wiki\/Zolpidem\">zolpidem<\/a>\u00a0and\u00a0<a title=\"Zopiclone\" href=\"https:\/\/en.wikipedia.org\/wiki\/Zopiclone\">zopiclone<\/a>\u00a0as well as\u00a0<a title=\"Opiate\" href=\"https:\/\/en.wikipedia.org\/wiki\/Opiate\">opiates<\/a>\u00a0and illegal drugs is common in alcoholics. Alcohol itself is a sedative-hypnotic and is cross-tolerant with other sedative-hypnotics such as\u00a0<a title=\"Barbiturate\" href=\"https:\/\/en.wikipedia.org\/wiki\/Barbiturate\">barbiturates<\/a>, benzodiazepines and\u00a0<a title=\"Nonbenzodiazepine\" href=\"https:\/\/en.wikipedia.org\/wiki\/Nonbenzodiazepine\">nonbenzodiazepines<\/a>. Dependence upon and withdrawal from sedative-hypnotics can be medically severe and, as with alcohol withdrawal, there is a risk of\u00a0<a title=\"Psychosis\" href=\"https:\/\/en.wikipedia.org\/wiki\/Psychosis\">psychosis<\/a>\u00a0or\u00a0<a title=\"Seizure\" href=\"https:\/\/en.wikipedia.org\/wiki\/Seizure\">seizures<\/a>\u00a0if not properly managed.<sup id=\"cite_ref-dolpdaa_153-0\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-dolpdaa-153\">[153]<\/a><\/sup>","rendered":"<p><b>Alcoholism<\/b>\u00a0is, broadly, any drinking of\u00a0<a title=\"Alcohol (drug)\" href=\"https:\/\/en.wikipedia.org\/wiki\/Alcohol_(drug)\">alcohol<\/a>\u00a0that results in significant\u00a0<a title=\"Mental health\" href=\"https:\/\/en.wikipedia.org\/wiki\/Mental_health\">mental<\/a>\u00a0or physical\u00a0<a title=\"Health\" href=\"https:\/\/en.wikipedia.org\/wiki\/Health\">health<\/a>\u00a0problems.<sup id=\"cite_ref-14\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-14\">[14]<\/a><\/sup>\u00a0Alcoholism is not a recognized diagnostic entity. Predominant diagnostic classifications are\u00a0<b>alcohol use disorder<\/b><sup id=\"cite_ref-NIH2013_2-2\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-NIH2013-2\">[2]<\/a><\/sup>\u00a0(<a title=\"DSM-5\" href=\"https:\/\/en.wikipedia.org\/wiki\/DSM-5\">DSM-5<\/a>)<sup id=\"cite_ref-DSM5_4-4\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-DSM5-4\">[4]<\/a><\/sup>\u00a0or\u00a0<a title=\"Alcohol dependence\" href=\"https:\/\/en.wikipedia.org\/wiki\/Alcohol_dependence\">alcohol dependence<\/a>\u00a0(<a title=\"ICD-11\" href=\"https:\/\/en.wikipedia.org\/wiki\/ICD-11\">ICD-11<\/a>).<sup id=\"cite_ref-15\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-15\">[15]<\/a><\/sup><\/p>\n<h2><span id=\"Signs_and_symptoms\" class=\"mw-headline\">Signs and symptoms<\/span><\/h2>\n<div class=\"thumb tright\">\n<div class=\"thumbinner\">\n<div id=\"mwe_player_0\" class=\"PopUpMediaTransform\" style=\"margin: 0px auto;width: 350px\"><img decoding=\"async\" class=\"aligncenter\" src=\"https:\/\/upload.wikimedia.org\/wikipedia\/commons\/thumb\/4\/45\/What_Alcohol_Does_to_Your_Body.webm\/350px--What_Alcohol_Does_to_Your_Body.webm.jpg\" alt=\"File:What Alcohol Does to Your Body.webm\" \/><\/div>\n<div class=\"thumbcaption\">\n<div class=\"magnify\"><\/div>\n<\/div>\n<\/div>\n<\/div>\n<p>The risk of alcohol dependence begins at low levels of drinking and increases directly with both the volume of alcohol consumed and a pattern of\u00a0<a title=\"Binge drinking\" href=\"https:\/\/en.wikipedia.org\/wiki\/Binge_drinking\">drinking larger amounts on an occasion<\/a>, to the point of intoxication, which is sometimes called &#8220;binge drinking&#8221;.<\/p>\n<h2><span id=\"Alcohol_misuse\" class=\"mw-headline\">Alcohol misuse<\/span><\/h2>\n<div class=\"thumb tright\">\n<div class=\"thumbinner\">\n<div style=\"width: 360px\" class=\"wp-caption alignright\"><a class=\"image\" href=\"https:\/\/en.wikipedia.org\/wiki\/File:Possible_long-term_effects_of_ethanol.svg\"><img loading=\"lazy\" decoding=\"async\" class=\"thumbimage\" src=\"https:\/\/upload.wikimedia.org\/wikipedia\/commons\/thumb\/3\/34\/Possible_long-term_effects_of_ethanol.svg\/350px-Possible_long-term_effects_of_ethanol.svg.png\" alt=\"\" width=\"350\" height=\"250\" \/><\/a><\/p>\n<p class=\"wp-caption-text\">Effects of alcohol on the body<\/p>\n<\/div>\n<div class=\"thumbcaption\">\n<div class=\"magnify\"><\/div>\n<p>Some of the possible\u00a0<a class=\"mw-redirect\" title=\"Long-term effects of ethanol\" href=\"https:\/\/en.wikipedia.org\/wiki\/Long-term_effects_of_ethanol\">long-term effects of ethanol<\/a>\u00a0an individual may develop. Additionally, in pregnant women, alcohol can cause\u00a0<a class=\"mw-redirect\" title=\"Fetal alcohol syndrome\" href=\"https:\/\/en.wikipedia.org\/wiki\/Fetal_alcohol_syndrome\">fetal alcohol syndrome<\/a>.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<p>Alcoholism is characterised by an increased\u00a0<a title=\"Alcohol tolerance\" href=\"https:\/\/en.wikipedia.org\/wiki\/Alcohol_tolerance\">tolerance<\/a>\u00a0to alcohol\u00a0\u2013 which means that an individual can consume more alcohol\u00a0\u2013 and\u00a0<a title=\"Physical dependence\" href=\"https:\/\/en.wikipedia.org\/wiki\/Physical_dependence\">physical dependence<\/a>\u00a0on alcohol, which makes it hard for an individual to control their consumption. The physical dependency caused by alcohol can lead to an affected individual having a very strong urge to drink alcohol. These characteristics play a role in decreasing an alcoholic&#8217;s ability to stop drinking.<sup id=\"cite_ref-Hoffman-1996_29-0\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-Hoffman-1996-29\">[29]<\/a><\/sup>\u00a0Alcoholism can have adverse effects on mental health, contributing to psychiatric disorders and increasing the risk of suicide. A\u00a0<a title=\"Depression (mood)\" href=\"https:\/\/en.wikipedia.org\/wiki\/Depression_(mood)\">depressed mood<\/a>\u00a0is a common symptom of heavy alcohol drinkers.<sup id=\"cite_ref-30\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-30\">[30]<\/a><\/sup><sup id=\"cite_ref-drug_abuse_prevention_a03_31-0\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-drug_abuse_prevention_a03-31\">[31]<\/a><\/sup><\/p>\n<div class=\"textbox examples\">\n<h3>watch<\/h3>\n<p><iframe loading=\"lazy\" id=\"oembed-1\" title=\"What is alcoholism &amp; how do we treat it? Alcohol Use Disorder\" width=\"500\" height=\"281\" src=\"https:\/\/www.youtube.com\/embed\/mfMBCBLVCvY?feature=oembed&#38;rel=0\" frameborder=\"0\" allowfullscreen=\"allowfullscreen\"><\/iframe><\/p>\n<\/div>\n<p>&nbsp;<\/p>\n<h3><span id=\"Warning_signs\" class=\"mw-headline\">Warning signs<\/span><\/h3>\n<p>Warning signs of alcoholism include the consumption of increasing amounts of alcohol and frequent intoxication, preoccupation with drinking to the exclusion of other activities, promises to quit drinking and failure to keep those promises, the inability to remember what was said or done while drinking (colloquially known as &#8220;blackouts&#8221;), personality changes associated with drinking, denial or the making of excuses for drinking, the refusal to admit excessive drinking, dysfunction or other problems at work or school, the loss of interest in personal appearance or hygiene, marital and economic problems, and the complaint of poor health, with loss of appetite, respiratory infections, or increased anxiety.<sup id=\"cite_ref-32\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-32\">[32]<\/a><\/sup><\/p>\n<h4><span id=\"Physical\" class=\"mw-headline\">Physical<\/span><\/h4>\n<h5><span id=\"Short-term_effects\" class=\"mw-headline\">Short-term effects<\/span><\/h5>\n<div class=\"hatnote navigation-not-searchable\" role=\"note\">Main article:\u00a0<a title=\"Short-term effects of alcohol consumption\" href=\"https:\/\/en.wikipedia.org\/wiki\/Short-term_effects_of_alcohol_consumption\">Short-term effects of alcohol consumption<\/a><\/div>\n<p>Drinking enough to cause a\u00a0<a class=\"mw-redirect\" title=\"Blood alcohol concentration\" href=\"https:\/\/en.wikipedia.org\/wiki\/Blood_alcohol_concentration\">blood alcohol concentration<\/a>\u00a0(BAC) of 0.03\u20130.12% typically causes an overall improvement in mood and possible\u00a0<a title=\"Euphoria\" href=\"https:\/\/en.wikipedia.org\/wiki\/Euphoria\">euphoria<\/a>\u00a0(a &#8220;happy&#8221; feeling), increased self-confidence and sociability, decreased anxiety, a\u00a0<a title=\"Alcohol flush reaction\" href=\"https:\/\/en.wikipedia.org\/wiki\/Alcohol_flush_reaction\">flushed, red appearance in the face<\/a>\u00a0and impaired judgment and fine muscle coordination. A BAC of 0.09% to 0.25% causes\u00a0<a title=\"Lethargy\" href=\"https:\/\/en.wikipedia.org\/wiki\/Lethargy\">lethargy<\/a>,\u00a0<a title=\"Sedation\" href=\"https:\/\/en.wikipedia.org\/wiki\/Sedation\">sedation<\/a>, balance problems and blurred vision. A BAC of 0.18% to 0.30% causes profound confusion, impaired speech (e.g. slurred speech), staggering, dizziness and vomiting. A BAC from 0.25% to 0.40% causes\u00a0<a title=\"Stupor\" href=\"https:\/\/en.wikipedia.org\/wiki\/Stupor\">stupor<\/a>, unconsciousness,\u00a0<a title=\"Anterograde amnesia\" href=\"https:\/\/en.wikipedia.org\/wiki\/Anterograde_amnesia\">anterograde amnesia<\/a>, vomiting (death may occur due to\u00a0<a title=\"Pulmonary aspiration\" href=\"https:\/\/en.wikipedia.org\/wiki\/Pulmonary_aspiration\">inhalation of vomit<\/a>\u00a0while unconscious) and\u00a0<a class=\"mw-redirect\" title=\"Respiratory depression\" href=\"https:\/\/en.wikipedia.org\/wiki\/Respiratory_depression\">respiratory depression<\/a>\u00a0(potentially life-threatening). A BAC from 0.35% to 0.80% causes a\u00a0<a title=\"Coma\" href=\"https:\/\/en.wikipedia.org\/wiki\/Coma\">coma<\/a>\u00a0(unconsciousness), life-threatening respiratory depression and possibly fatal\u00a0<a class=\"mw-redirect\" title=\"Alcohol poisoning\" href=\"https:\/\/en.wikipedia.org\/wiki\/Alcohol_poisoning\">alcohol poisoning<\/a>. With all alcoholic beverages,\u00a0<a class=\"mw-redirect\" title=\"Drinking and driving\" href=\"https:\/\/en.wikipedia.org\/wiki\/Drinking_and_driving\">drinking while driving<\/a>, operating an aircraft or heavy machinery increases the risk of an accident; many countries have penalties for drunk driving.<\/p>\n<h5><span id=\"Long-term_effects\" class=\"mw-headline\">Long-term effects<\/span><\/h5>\n<div class=\"hatnote navigation-not-searchable\" role=\"note\">See also:\u00a0<a class=\"mw-redirect\" title=\"Long-term effects of alcohol consumption\" href=\"https:\/\/en.wikipedia.org\/wiki\/Long-term_effects_of_alcohol_consumption\">Long-term effects of alcohol consumption<\/a><\/div>\n<p>Having more than one drink a day for women or two drinks for men increases the risk of heart disease,\u00a0<a class=\"mw-redirect\" title=\"High blood pressure\" href=\"https:\/\/en.wikipedia.org\/wiki\/High_blood_pressure\">high blood pressure<\/a>,\u00a0<a title=\"Atrial fibrillation\" href=\"https:\/\/en.wikipedia.org\/wiki\/Atrial_fibrillation\">atrial fibrillation<\/a>, and\u00a0<a title=\"Stroke\" href=\"https:\/\/en.wikipedia.org\/wiki\/Stroke\">stroke<\/a>.<sup id=\"cite_ref-Kee2014_33-0\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-Kee2014-33\">[33]<\/a><\/sup>\u00a0Risk is greater with\u00a0<a title=\"Binge drinking\" href=\"https:\/\/en.wikipedia.org\/wiki\/Binge_drinking\">binge drinking<\/a>, which may also result in violence or accidents. About 3.3\u00a0million deaths (5.9% of all deaths) are believed to be due to alcohol each year.<sup id=\"cite_ref-NIH2015Stats_13-3\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-NIH2015Stats-13\">[13]<\/a><\/sup>\u00a0Alcoholism reduces a person&#8217;s life expectancy by around ten years<sup id=\"cite_ref-Schu2014_26-1\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-Schu2014-26\">[26]<\/a><\/sup>\u00a0and alcohol use is the third leading cause of early death in the United States.<sup id=\"cite_ref-Kee2014_33-1\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-Kee2014-33\">[33]<\/a><\/sup>\u00a0No professional medical association recommends that people who are nondrinkers should start drinking.<sup id=\"cite_ref-Kee2014_33-2\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-Kee2014-33\">[33]<\/a><\/sup><sup id=\"cite_ref-34\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-34\">[34]<\/a><\/sup>\u00a0Long-term alcohol misuse can cause a number of physical symptoms, including\u00a0<a title=\"Cirrhosis\" href=\"https:\/\/en.wikipedia.org\/wiki\/Cirrhosis\">cirrhosis<\/a>\u00a0of the liver,\u00a0<a title=\"Pancreatitis\" href=\"https:\/\/en.wikipedia.org\/wiki\/Pancreatitis\">pancreatitis<\/a>,\u00a0<a title=\"Epilepsy\" href=\"https:\/\/en.wikipedia.org\/wiki\/Epilepsy\">epilepsy<\/a>,\u00a0<a title=\"Polyneuropathy\" href=\"https:\/\/en.wikipedia.org\/wiki\/Polyneuropathy\">polyneuropathy<\/a>,\u00a0<a class=\"mw-redirect\" title=\"Wernicke-Korsakoff syndrome\" href=\"https:\/\/en.wikipedia.org\/wiki\/Wernicke-Korsakoff_syndrome\">alcoholic dementia<\/a>, heart disease, nutritional deficiencies,\u00a0<a class=\"mw-redirect\" title=\"Duodenal ulcer\" href=\"https:\/\/en.wikipedia.org\/wiki\/Duodenal_ulcer\">peptic ulcers<\/a><sup id=\"cite_ref-35\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-35\">[35]<\/a><\/sup>\u00a0and\u00a0<a title=\"Sexual dysfunction\" href=\"https:\/\/en.wikipedia.org\/wiki\/Sexual_dysfunction\">sexual dysfunction<\/a>, and can eventually be fatal. Other physical effects include an increased risk of developing\u00a0<a title=\"Cardiovascular disease\" href=\"https:\/\/en.wikipedia.org\/wiki\/Cardiovascular_disease\">cardiovascular disease<\/a>,\u00a0<a title=\"Malabsorption\" href=\"https:\/\/en.wikipedia.org\/wiki\/Malabsorption\">malabsorption<\/a>,\u00a0<a title=\"Alcoholic liver disease\" href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholic_liver_disease\">alcoholic liver disease<\/a>, and several\u00a0<a title=\"Cancer\" href=\"https:\/\/en.wikipedia.org\/wiki\/Cancer\">cancers<\/a>. Damage to the\u00a0<a title=\"Central nervous system\" href=\"https:\/\/en.wikipedia.org\/wiki\/Central_nervous_system\">central nervous system<\/a>\u00a0and\u00a0<a title=\"Peripheral nervous system\" href=\"https:\/\/en.wikipedia.org\/wiki\/Peripheral_nervous_system\">peripheral nervous system<\/a>\u00a0can occur from sustained alcohol consumption.<sup id=\"cite_ref-36\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-36\">[36]<\/a><\/sup><sup id=\"cite_ref-37\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-37\">[37]<\/a><\/sup>\u00a0A wide range of immunologic defects can result and there may be a generalized skeletal fragility, in addition to a recognized tendency to accidental injury, resulting a propensity to bone fractures.<sup id=\"cite_ref-38\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-38\">[38]<\/a><\/sup><\/p>\n<p>Women develop long-term complications of alcohol dependence more rapidly than do men. Additionally, women have a higher mortality rate from alcoholism than men.<sup id=\"cite_ref-Blume_Laura_N.,_Nielson_Nancy_H.,_Riggs_Joseph_A.,_et_all_1998_861\u2013870_39-0\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-Blume_Laura_N.,_Nielson_Nancy_H.,_Riggs_Joseph_A.,_et_all_1998_861%E2%80%93870-39\">[39]<\/a><\/sup>\u00a0Examples of long-term complications include brain, heart, and liver damage<sup id=\"cite_ref-Walter_H.,_Gutierrez_K.,_Ramskogler_K.,_Hertling_I.,_Dvorak_A.,_Lesch_O.M.,_et_al._2003_253\u2013268_40-0\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-Walter_H.,_Gutierrez_K.,_Ramskogler_K.,_Hertling_I.,_Dvorak_A.,_Lesch_O.M.,_et_al._2003_253%E2%80%93268-40\">[40]<\/a><\/sup>\u00a0and an\u00a0<a title=\"Alcohol and breast cancer\" href=\"https:\/\/en.wikipedia.org\/wiki\/Alcohol_and_breast_cancer\">increased risk of breast cancer<\/a>. Additionally, heavy drinking over time has been found to have a negative effect on reproductive functioning in women. This results in reproductive dysfunction such as\u00a0<a title=\"Anovulation\" href=\"https:\/\/en.wikipedia.org\/wiki\/Anovulation\">anovulation<\/a>, decreased ovarian mass, problems or irregularity of the\u00a0<a title=\"Menstrual cycle\" href=\"https:\/\/en.wikipedia.org\/wiki\/Menstrual_cycle\">menstrual cycle<\/a>, and early\u00a0<a title=\"Menopause\" href=\"https:\/\/en.wikipedia.org\/wiki\/Menopause\">menopause<\/a>.<sup id=\"cite_ref-Blume_Laura_N.,_Nielson_Nancy_H.,_Riggs_Joseph_A.,_et_all_1998_861\u2013870_39-1\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-Blume_Laura_N.,_Nielson_Nancy_H.,_Riggs_Joseph_A.,_et_all_1998_861%E2%80%93870-39\">[39]<\/a><\/sup>\u00a0Alcoholic\u00a0<a title=\"Ketoacidosis\" href=\"https:\/\/en.wikipedia.org\/wiki\/Ketoacidosis\">ketoacidosis<\/a>\u00a0can occur in individuals who chronically misuse alcohol and have a recent history of\u00a0<a title=\"Binge drinking\" href=\"https:\/\/en.wikipedia.org\/wiki\/Binge_drinking\">binge drinking<\/a>.<sup id=\"cite_ref-Mihai-_41-0\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-Mihai--41\">[41]<\/a><\/sup><sup id=\"cite_ref-Siba\u00ef-2005_42-0\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-Siba%C3%AF-2005-42\">[42]<\/a><\/sup>\u00a0The amount of alcohol that can be biologically processed and its effects differ between sexes. Equal dosages of alcohol consumed by men and women generally result in women having higher\u00a0<a class=\"mw-redirect\" title=\"Blood alcohol concentration\" href=\"https:\/\/en.wikipedia.org\/wiki\/Blood_alcohol_concentration\">blood alcohol concentrations<\/a>\u00a0(BACs), since women generally have a lower weight and higher percentage of body fat and therefore a lower volume of distribution for alcohol than men.<sup id=\"cite_ref-pmid23101976_43-0\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-pmid23101976-43\">[43]<\/a><\/sup><\/p>\n<h4><span id=\"Psychiatric\" class=\"mw-headline\">Psychiatric<\/span><\/h4>\n<p>Long-term misuse of alcohol can cause a wide range of\u00a0<a title=\"Mental health\" href=\"https:\/\/en.wikipedia.org\/wiki\/Mental_health\">mental health<\/a>\u00a0problems. Severe\u00a0<a class=\"mw-redirect\" title=\"Cognitive\" href=\"https:\/\/en.wikipedia.org\/wiki\/Cognitive\">cognitive<\/a>\u00a0problems are common; approximately 10 percent of all dementia cases are related to alcohol consumption, making it the second leading cause of\u00a0<a title=\"Dementia\" href=\"https:\/\/en.wikipedia.org\/wiki\/Dementia\">dementia<\/a>.<sup id=\"cite_ref-aamaibnc_44-0\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-aamaibnc-44\">[44]<\/a><\/sup>\u00a0Excessive alcohol use causes\u00a0<a title=\"Brain damage\" href=\"https:\/\/en.wikipedia.org\/wiki\/Brain_damage\">damage to brain function<\/a>, and psychological health can be increasingly affected over time.<sup id=\"cite_ref-45\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-45\">[45]<\/a><\/sup>\u00a0<a title=\"Social skills\" href=\"https:\/\/en.wikipedia.org\/wiki\/Social_skills\">Social skills<\/a>\u00a0are significantly impaired in people suffering from alcoholism due to the neurotoxic effects of alcohol on the brain, especially the\u00a0<a title=\"Prefrontal cortex\" href=\"https:\/\/en.wikipedia.org\/wiki\/Prefrontal_cortex\">prefrontal cortex<\/a>\u00a0area of the brain. The social skills that are impaired by alcohol use disorder include impairments in perceiving facial emotions,\u00a0<a title=\"Prosody (linguistics)\" href=\"https:\/\/en.wikipedia.org\/wiki\/Prosody_(linguistics)\">prosody<\/a>, perception problems, and\u00a0<a title=\"Theory of mind\" href=\"https:\/\/en.wikipedia.org\/wiki\/Theory_of_mind\">theory of mind<\/a>\u00a0deficits; the ability to understand humor is also impaired in people who misuse alcohol.<sup id=\"cite_ref-pmid18412750_46-0\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-pmid18412750-46\">[46]<\/a><\/sup>\u00a0Psychiatric disorders are common in alcoholics, with as many as 25 percent suffering severe psychiatric disturbances. The most prevalent psychiatric symptoms are\u00a0<a title=\"Anxiety disorder\" href=\"https:\/\/en.wikipedia.org\/wiki\/Anxiety_disorder\">anxiety<\/a>\u00a0and\u00a0<a title=\"Major depressive disorder\" href=\"https:\/\/en.wikipedia.org\/wiki\/Major_depressive_disorder\">depression<\/a>\u00a0disorders. Psychiatric symptoms usually initially worsen during alcohol withdrawal, but typically improve or disappear with continued abstinence.<sup id=\"cite_ref-47\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-47\">[47]<\/a><\/sup>\u00a0<a title=\"Psychosis\" href=\"https:\/\/en.wikipedia.org\/wiki\/Psychosis\">Psychosis<\/a>,\u00a0<a title=\"Confusion\" href=\"https:\/\/en.wikipedia.org\/wiki\/Confusion\">confusion<\/a>, and\u00a0<a title=\"Organic brain syndrome\" href=\"https:\/\/en.wikipedia.org\/wiki\/Organic_brain_syndrome\">organic brain syndrome<\/a>\u00a0may be caused by alcohol misuse, which can lead to a misdiagnosis such as\u00a0<a title=\"Schizophrenia\" href=\"https:\/\/en.wikipedia.org\/wiki\/Schizophrenia\">schizophrenia<\/a>.<sup id=\"cite_ref-48\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-48\">[48]<\/a><\/sup>\u00a0<a title=\"Panic disorder\" href=\"https:\/\/en.wikipedia.org\/wiki\/Panic_disorder\">Panic disorder<\/a>\u00a0can develop or worsen as a direct result of long-term alcohol misuse.<sup id=\"cite_ref-49\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-49\">[49]<\/a><\/sup><sup id=\"cite_ref-50\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-50\">[50]<\/a><\/sup><\/p>\n<p>The co-occurrence of\u00a0<a title=\"Major depressive disorder\" href=\"https:\/\/en.wikipedia.org\/wiki\/Major_depressive_disorder\">major depressive disorder<\/a>\u00a0and alcoholism is well documented.<sup id=\"cite_ref-51\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-51\">[51]<\/a><\/sup><sup id=\"cite_ref-52\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-52\">[52]<\/a><\/sup><sup id=\"cite_ref-53\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-53\">[53]<\/a><\/sup>\u00a0Among those with\u00a0<a class=\"mw-redirect\" title=\"Comorbid\" href=\"https:\/\/en.wikipedia.org\/wiki\/Comorbid\">comorbid<\/a>\u00a0occurrences, a distinction is commonly made between depressive episodes that remit with alcohol abstinence (&#8220;substance-induced&#8221;), and depressive episodes that are primary and do not remit with abstinence (&#8220;independent&#8221; episodes).<sup id=\"cite_ref-54\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-54\">[54]<\/a><\/sup><sup id=\"cite_ref-55\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-55\">[55]<\/a><\/sup><sup id=\"cite_ref-56\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-56\">[56]<\/a><\/sup>\u00a0Additional use of other drugs may increase the risk of depression.<sup id=\"cite_ref-57\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-57\">[57]<\/a><\/sup>\u00a0Psychiatric disorders differ depending on gender. Women who have alcohol-use disorders often have a co-occurring psychiatric diagnosis such as\u00a0<a class=\"mw-redirect\" title=\"Major depression\" href=\"https:\/\/en.wikipedia.org\/wiki\/Major_depression\">major depression<\/a>,\u00a0<a title=\"Anxiety\" href=\"https:\/\/en.wikipedia.org\/wiki\/Anxiety\">anxiety<\/a>,\u00a0<a title=\"Panic disorder\" href=\"https:\/\/en.wikipedia.org\/wiki\/Panic_disorder\">panic disorder<\/a>,\u00a0<a class=\"mw-redirect\" title=\"Bulimia\" href=\"https:\/\/en.wikipedia.org\/wiki\/Bulimia\">bulimia<\/a>,\u00a0<a title=\"Post-traumatic stress disorder\" href=\"https:\/\/en.wikipedia.org\/wiki\/Post-traumatic_stress_disorder\">post-traumatic stress disorder<\/a>\u00a0(PTSD), or\u00a0<a title=\"Borderline personality disorder\" href=\"https:\/\/en.wikipedia.org\/wiki\/Borderline_personality_disorder\">borderline personality disorder<\/a>. Men with alcohol-use disorders more often have a co-occurring diagnosis of\u00a0<a title=\"Narcissistic personality disorder\" href=\"https:\/\/en.wikipedia.org\/wiki\/Narcissistic_personality_disorder\">narcissistic<\/a>\u00a0or\u00a0<a title=\"Antisocial personality disorder\" href=\"https:\/\/en.wikipedia.org\/wiki\/Antisocial_personality_disorder\">antisocial personality disorder<\/a>,\u00a0<a title=\"Bipolar disorder\" href=\"https:\/\/en.wikipedia.org\/wiki\/Bipolar_disorder\">bipolar disorder<\/a>,\u00a0<a title=\"Schizophrenia\" href=\"https:\/\/en.wikipedia.org\/wiki\/Schizophrenia\">schizophrenia<\/a>,\u00a0<a class=\"mw-redirect\" title=\"Impulse disorder\" href=\"https:\/\/en.wikipedia.org\/wiki\/Impulse_disorder\">impulse disorders<\/a>\u00a0or\u00a0<a class=\"mw-redirect\" title=\"Attention deficit\/hyperactivity disorder\" href=\"https:\/\/en.wikipedia.org\/wiki\/Attention_deficit\/hyperactivity_disorder\">attention deficit\/hyperactivity disorder<\/a>\u00a0(ADHD).<sup id=\"cite_ref-Karrol_Brad_R._2002_337\u2013356_58-0\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-Karrol_Brad_R._2002_337%E2%80%93356-58\">[58]<\/a><\/sup>\u00a0Women with alcohol use disorder are more likely to experience physical or\u00a0<a title=\"Sexual assault\" href=\"https:\/\/en.wikipedia.org\/wiki\/Sexual_assault\">sexual assault<\/a>, abuse, and\u00a0<a title=\"Domestic violence\" href=\"https:\/\/en.wikipedia.org\/wiki\/Domestic_violence\">domestic violence<\/a>\u00a0than women in the general population,<sup id=\"cite_ref-Karrol_Brad_R._2002_337\u2013356_58-1\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-Karrol_Brad_R._2002_337%E2%80%93356-58\">[58]<\/a><\/sup>\u00a0which can lead to higher instances of psychiatric disorders and greater dependence on alcohol.<\/p>\n<h4><span id=\"Social_effects\" class=\"mw-headline\">Social effects<\/span><\/h4>\n<div class=\"hatnote navigation-not-searchable\" role=\"note\">See also:\u00a0<a title=\"Drug-related crime\" href=\"https:\/\/en.wikipedia.org\/wiki\/Drug-related_crime\">Drug-related crime<\/a><\/div>\n<p>Serious social problems arise from alcohol use disorder; these dilemmas are caused by the pathological changes in the brain and the intoxicating effects of alcohol.<sup id=\"cite_ref-aamaibnc_44-1\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-aamaibnc-44\">[44]<\/a><\/sup><sup id=\"cite_ref-Jessica_Kingsley_Publishers_59-0\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-Jessica_Kingsley_Publishers-59\">[59]<\/a><\/sup>\u00a0Alcohol misuse is associated with an increased risk of committing criminal offences, including\u00a0<a title=\"Child abuse\" href=\"https:\/\/en.wikipedia.org\/wiki\/Child_abuse\">child abuse<\/a>,\u00a0<a title=\"Domestic violence\" href=\"https:\/\/en.wikipedia.org\/wiki\/Domestic_violence\">domestic violence<\/a>,\u00a0<a title=\"Rape\" href=\"https:\/\/en.wikipedia.org\/wiki\/Rape\">rape<\/a>,\u00a0<a title=\"Burglary\" href=\"https:\/\/en.wikipedia.org\/wiki\/Burglary\">burglary<\/a>\u00a0and\u00a0<a title=\"Assault\" href=\"https:\/\/en.wikipedia.org\/wiki\/Assault\">assault<\/a>.<sup id=\"cite_ref-drug_use_a_reference_handbook_60-0\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-drug_use_a_reference_handbook-60\">[60]<\/a><\/sup>\u00a0Alcoholism is associated with\u00a0<a title=\"Termination of employment\" href=\"https:\/\/en.wikipedia.org\/wiki\/Termination_of_employment\">loss of employment<\/a>,<sup id=\"cite_ref-61\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-61\">[61]<\/a><\/sup>\u00a0which can lead to financial problems. Drinking at inappropriate times and behavior caused by reduced judgment can lead to legal consequences, such as criminal charges for\u00a0<a title=\"Drunk driving\" href=\"https:\/\/en.wikipedia.org\/wiki\/Drunk_driving\">drunk driving<\/a><sup id=\"cite_ref-abd2009_62-0\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-abd2009-62\">[62]<\/a><\/sup>\u00a0or public disorder, or civil penalties for\u00a0<a title=\"Tort\" href=\"https:\/\/en.wikipedia.org\/wiki\/Tort\">tortious<\/a>\u00a0behavior. An alcoholic&#8217;s behavior and mental impairment while drunk can profoundly affect those surrounding him and lead to isolation from family and friends. This isolation can lead to\u00a0<a title=\"Relational disorder\" href=\"https:\/\/en.wikipedia.org\/wiki\/Relational_disorder\">marital conflict<\/a>\u00a0and\u00a0<a title=\"Divorce\" href=\"https:\/\/en.wikipedia.org\/wiki\/Divorce\">divorce<\/a>, or contribute to\u00a0<a title=\"Domestic violence\" href=\"https:\/\/en.wikipedia.org\/wiki\/Domestic_violence\">domestic violence<\/a>. Alcoholism can also lead to\u00a0<a title=\"Child neglect\" href=\"https:\/\/en.wikipedia.org\/wiki\/Child_neglect\">child neglect<\/a>, with subsequent lasting damage to the emotional development of the alcoholic&#8217;s children.<sup id=\"cite_ref-tcemh2006_63-0\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-tcemh2006-63\">[63]<\/a><\/sup>\u00a0For this reason, children of alcoholic parents can develop a number of emotional problems. For example, they can become afraid of their parents, because of their unstable mood behaviors. In addition, they can develop considerable amount of shame over their inadequacy to liberate their parents from alcoholism. As a result of this failure, they develop wretched self-images, which can lead to depression.<sup id=\"cite_ref-64\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-64\">[64]<\/a><\/sup><\/p>\n<h3><span id=\"Alcohol_withdrawal\" class=\"mw-headline\">Alcohol withdrawal<\/span><\/h3>\n<div class=\"thumb tright\">\n<div class=\"thumbinner\">\n<div class=\"thumbcaption\"><span style=\"font-size: 1rem;text-align: initial\">As with similar substances with a sedative-hypnotic mechanism, such as\u00a0<\/span><a class=\"mw-redirect\" style=\"font-size: 1rem;text-align: initial\" title=\"Barbiturates\" href=\"https:\/\/en.wikipedia.org\/wiki\/Barbiturates\">barbiturates<\/a><span style=\"font-size: 1rem;text-align: initial\">\u00a0and\u00a0<\/span><a class=\"mw-redirect\" style=\"font-size: 1rem;text-align: initial\" title=\"Benzodiazepines\" href=\"https:\/\/en.wikipedia.org\/wiki\/Benzodiazepines\">benzodiazepines<\/a><span style=\"font-size: 1rem;text-align: initial\">, withdrawal from alcohol dependence can be fatal if it is not properly managed.<\/span><sup id=\"cite_ref-Jessica_Kingsley_Publishers_59-1\" class=\"reference\" style=\"text-align: initial\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-Jessica_Kingsley_Publishers-59\">[59]<\/a><\/sup><sup id=\"cite_ref-65\" class=\"reference\" style=\"text-align: initial\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-65\">[65]<\/a><\/sup><span style=\"font-size: 1rem;text-align: initial\">\u00a0Alcohol&#8217;s primary effect is the increase in stimulation of the\u00a0<\/span><a style=\"font-size: 1rem;text-align: initial\" title=\"GABAA receptor\" href=\"https:\/\/en.wikipedia.org\/wiki\/GABAA_receptor\">GABA<sub>A<\/sub>\u00a0receptor<\/a><span style=\"font-size: 1rem;text-align: initial\">, promoting\u00a0<\/span><a style=\"font-size: 1rem;text-align: initial\" title=\"Central nervous system\" href=\"https:\/\/en.wikipedia.org\/wiki\/Central_nervous_system\">central nervous system<\/a><span style=\"font-size: 1rem;text-align: initial\">\u00a0depression. With repeated heavy consumption of alcohol, these receptors are desensitized and reduced in number, resulting in\u00a0<\/span><a style=\"font-size: 1rem;text-align: initial\" title=\"Drug tolerance\" href=\"https:\/\/en.wikipedia.org\/wiki\/Drug_tolerance\">tolerance<\/a><span style=\"font-size: 1rem;text-align: initial\">\u00a0and\u00a0<\/span><a style=\"font-size: 1rem;text-align: initial\" title=\"Physical dependence\" href=\"https:\/\/en.wikipedia.org\/wiki\/Physical_dependence\">physical dependence<\/a><span style=\"font-size: 1rem;text-align: initial\">. When alcohol consumption is stopped too abruptly, the person&#8217;s nervous system suffers from uncontrolled\u00a0<\/span><a style=\"font-size: 1rem;text-align: initial\" title=\"Synapse\" href=\"https:\/\/en.wikipedia.org\/wiki\/Synapse\">synapse<\/a><span style=\"font-size: 1rem;text-align: initial\">\u00a0firing. This can result in symptoms that include\u00a0<\/span><a class=\"mw-redirect\" style=\"font-size: 1rem;text-align: initial\" title=\"Anxiety (mood)\" href=\"https:\/\/en.wikipedia.org\/wiki\/Anxiety_(mood)\">anxiety<\/a><span style=\"font-size: 1rem;text-align: initial\">, life-threatening\u00a0<\/span><a style=\"font-size: 1rem;text-align: initial\" title=\"Seizure\" href=\"https:\/\/en.wikipedia.org\/wiki\/Seizure\">seizures<\/a><span style=\"font-size: 1rem;text-align: initial\">,\u00a0<\/span><a style=\"font-size: 1rem;text-align: initial\" title=\"Delirium tremens\" href=\"https:\/\/en.wikipedia.org\/wiki\/Delirium_tremens\">delirium tremens<\/a><span style=\"font-size: 1rem;text-align: initial\">, hallucinations, shakes and possible\u00a0<\/span><a style=\"font-size: 1rem;text-align: initial\" title=\"Heart failure\" href=\"https:\/\/en.wikipedia.org\/wiki\/Heart_failure\">heart failure<\/a><span style=\"font-size: 1rem;text-align: initial\">.<\/span><sup id=\"cite_ref-Medical_toxicology_66-0\" class=\"reference\" style=\"text-align: initial\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-Medical_toxicology-66\">[66]<\/a><\/sup><sup id=\"cite_ref-67\" class=\"reference\" style=\"text-align: initial\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-67\">[67]<\/a><\/sup><span style=\"font-size: 1rem;text-align: initial\">\u00a0Other neurotransmitter systems are also involved, especially\u00a0<\/span><a style=\"font-size: 1rem;text-align: initial\" title=\"Dopamine\" href=\"https:\/\/en.wikipedia.org\/wiki\/Dopamine\">dopamine<\/a><span style=\"font-size: 1rem;text-align: initial\">,\u00a0<\/span><a class=\"mw-redirect\" style=\"font-size: 1rem;text-align: initial\" title=\"NMDA\" href=\"https:\/\/en.wikipedia.org\/wiki\/NMDA\">NMDA<\/a><span style=\"font-size: 1rem;text-align: initial\">\u00a0and\u00a0<\/span><a class=\"mw-redirect\" style=\"font-size: 1rem;text-align: initial\" title=\"Glutamate\" href=\"https:\/\/en.wikipedia.org\/wiki\/Glutamate\">glutamate<\/a><span style=\"font-size: 1rem;text-align: initial\">.<\/span><sup id=\"cite_ref-Hoffman-1996_29-1\" class=\"reference\" style=\"text-align: initial\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-Hoffman-1996-29\">[29]<\/a><\/sup><sup id=\"cite_ref-68\" class=\"reference\" style=\"text-align: initial\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-68\">[68]<\/a><\/sup><\/div>\n<\/div>\n<\/div>\n<p>Severe acute withdrawal symptoms such as\u00a0<a title=\"Delirium tremens\" href=\"https:\/\/en.wikipedia.org\/wiki\/Delirium_tremens\">delirium tremens<\/a>\u00a0and seizures rarely occur after 1-week post cessation of alcohol. The acute withdrawal phase can be defined as lasting between one and three weeks. In the period of 3\u20136 weeks following cessation, anxiety, depression, fatigue, and sleep disturbance are common.<sup id=\"cite_ref-pmid20148778_69-0\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-pmid20148778-69\">[69]<\/a><\/sup>\u00a0Similar post-acute withdrawal symptoms have also been observed in animal models of alcohol dependence and withdrawal.<sup id=\"cite_ref-70\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-70\">[70]<\/a><\/sup><\/p>\n<p>A\u00a0<a class=\"mw-redirect\" title=\"Kindling (sedative-hypnotic withdrawal)\" href=\"https:\/\/en.wikipedia.org\/wiki\/Kindling_(sedative-hypnotic_withdrawal)\">kindling effect<\/a>\u00a0also occurs in alcoholics whereby each subsequent withdrawal syndrome is more severe than the previous withdrawal episode; this is due to neuroadaptations which occur as a result of periods of abstinence followed by re-exposure to alcohol. Individuals who have had multiple withdrawal episodes are more likely to develop seizures and experience more severe anxiety during withdrawal from alcohol than alcohol-dependent individuals without a history of past alcohol withdrawal episodes. The kindling effect leads to persistent functional changes in brain neural circuits as well as to\u00a0<a title=\"Gene expression\" href=\"https:\/\/en.wikipedia.org\/wiki\/Gene_expression\">gene expression<\/a>.<sup id=\"cite_ref-Breese-2011_71-0\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-Breese-2011-71\">[71]<\/a><\/sup>\u00a0Kindling also results in the intensification of psychological symptoms of alcohol withdrawal.<sup id=\"cite_ref-pmid20148778_69-1\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-pmid20148778-69\">[69]<\/a><\/sup>\u00a0There are decision tools and questionnaires that help guide physicians in evaluating alcohol withdrawal. For example, the CIWA-Ar objectifies alcohol withdrawal symptoms in order to guide therapy decisions which allows for an efficient interview while at the same time retaining clinical usefulness, validity, and reliability, ensuring proper care for withdrawal patients, who can be in danger of death.<sup id=\"cite_ref-72\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-72\">[72]<\/a><\/sup><\/p>\n<h2><span id=\"Causes\" class=\"mw-headline\">Causes<\/span><\/h2>\n<div class=\"thumb tright\">\n<div class=\"thumbinner\">\n<p><a class=\"image\" href=\"https:\/\/en.wikipedia.org\/wiki\/File:William_Hogarth_-_Gin_Lane.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"thumbimage alignleft\" src=\"https:\/\/upload.wikimedia.org\/wikipedia\/commons\/thumb\/d\/d0\/William_Hogarth_-_Gin_Lane.jpg\/220px-William_Hogarth_-_Gin_Lane.jpg\" alt=\"\" width=\"220\" height=\"255\" \/><\/a><\/p>\n<div class=\"thumbcaption\">\n<div class=\"magnify\"><span style=\"font-size: 1rem;text-align: initial\">A complex combination of genetic and environmental factors influences the risk of the development of alcoholism. Drinking excessive alcohol during childhood or adolescence, is a risk factor, or to have low autoestime, thus to be someone with antisocial, addictive or wrathful behaviour, so as also minimize or naturalize so much alcohol misuse,\u00a0<\/span><a style=\"font-size: 1rem;text-align: initial\" title=\"Alcohol dependence\" href=\"https:\/\/en.wikipedia.org\/wiki\/Alcohol_dependence\">alcohol dependence<\/a><span style=\"font-size: 1rem;text-align: initial\">\u00a0and the\u00a0<\/span><a style=\"font-size: 1rem;text-align: initial\" title=\"Long-term effects of alcohol\" href=\"https:\/\/en.wikipedia.org\/wiki\/Long-term_effects_of_alcohol\">long-term effects of alcohol<\/a><span style=\"font-size: 1rem;text-align: initial\">\u00a0or also the\u00a0<\/span><a style=\"font-size: 1rem;text-align: initial\" title=\"Short-term effects of alcohol consumption\" href=\"https:\/\/en.wikipedia.org\/wiki\/Short-term_effects_of_alcohol_consumption\">short-term effects of alcohol consumption<\/a><span style=\"font-size: 1rem;text-align: initial\">\u00a0in the human body, is very known that some people depending of their life perspective or outlook can have more or less probabilities of to have drinking problems\u00a0<\/span><sup id=\"cite_ref-Enoch-2006_73-0\" class=\"reference\" style=\"text-align: initial\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-Enoch-2006-73\">[73]<\/a><\/sup><span style=\"font-size: 1rem;text-align: initial\">\u00a0Genes that influence the metabolism of alcohol also influence the risk of alcoholism, as can a family history of alcoholism.<\/span><sup id=\"cite_ref-Edenberg_2281\u20132297_74-0\" class=\"reference\" style=\"text-align: initial\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-Edenberg_2281%E2%80%932297-74\">[74]<\/a><\/sup><span style=\"font-size: 1rem;text-align: initial\">\u00a0There is compelling evidence that alcohol use at an early age may influence the\u00a0<\/span><a style=\"font-size: 1rem;text-align: initial\" title=\"Gene expression\" href=\"https:\/\/en.wikipedia.org\/wiki\/Gene_expression\">expression of genes<\/a><span style=\"font-size: 1rem;text-align: initial\">\u00a0which increase the risk of alcohol dependence. These genetic and\u00a0<\/span><a style=\"font-size: 1rem;text-align: initial\" title=\"Epigenetics\" href=\"https:\/\/en.wikipedia.org\/wiki\/Epigenetics\">epigenetic<\/a><span style=\"font-size: 1rem;text-align: initial\">\u00a0results are regarded as consistent with large longitudinal population studies finding that the younger the age of drinking onset, the greater the prevalence of lifetime alcohol dependence.<\/span><sup id=\"cite_ref-75\" class=\"reference\" style=\"text-align: initial\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-75\">[75]<\/a><\/sup><sup id=\"cite_ref-pmid27677720_76-0\" class=\"reference\" style=\"text-align: initial\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-pmid27677720-76\">[76]<\/a><\/sup><\/div>\n<\/div>\n<\/div>\n<\/div>\n<p><a title=\"Psychological trauma\" href=\"https:\/\/en.wikipedia.org\/wiki\/Psychological_trauma\">Severe childhood trauma<\/a>\u00a0is also associated with a general increase in the risk of drug dependency.<sup id=\"cite_ref-Enoch-2006_73-1\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-Enoch-2006-73\">[73]<\/a><\/sup>\u00a0Lack of peer and family support is associated with an increased risk of alcoholism developing.<sup id=\"cite_ref-Enoch-2006_73-2\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-Enoch-2006-73\">[73]<\/a><\/sup>\u00a0Genetics and adolescence are associated with an increased sensitivity to the neurotoxic effects of chronic alcohol use.\u00a0<a title=\"Cerebral cortex\" href=\"https:\/\/en.wikipedia.org\/wiki\/Cerebral_cortex\">Cortical<\/a>\u00a0degeneration due to the neurotoxic effects increases impulsive behaviour, which may contribute to the development, persistence and severity of alcohol use disorders. There is evidence that with abstinence, there is a reversal of at least some of the alcohol induced central nervous system damage.<sup id=\"cite_ref-Crews-2009_77-0\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-Crews-2009-77\">[77]<\/a><\/sup>\u00a0The use of cannabis was associated with later problems with alcohol use.<sup id=\"cite_ref-PMID26875671_78-0\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-PMID26875671-78\">[78]<\/a><\/sup>\u00a0Alcohol use was associated with an increased probability of later use of tobacco and illegal drugs such as cannabis.<sup id=\"cite_ref-PMID22712674_79-0\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-PMID22712674-79\">[79]<\/a><\/sup><\/p>\n<h3><span id=\"Screening\" class=\"mw-headline\">Screening<\/span><\/h3>\n<p>Screening is recommended among those over the age of 18.<sup id=\"cite_ref-111\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-111\">[111]<\/a><\/sup>\u00a0Several tools may be used to detect a loss of control of alcohol use. These tools are mostly\u00a0<a class=\"mw-redirect\" title=\"Self report study\" href=\"https:\/\/en.wikipedia.org\/wiki\/Self_report_study\">self-reports<\/a>\u00a0in questionnaire form. Another common theme is a score or tally that sums up the general severity of alcohol use.<sup id=\"cite_ref-Kahan-1996_112-0\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-Kahan-1996-112\">[112]<\/a><\/sup><\/p>\n<div class=\"textbox\">\n<p>The\u00a0<a title=\"CAGE questionnaire\" href=\"https:\/\/en.wikipedia.org\/wiki\/CAGE_questionnaire\">CAGE questionnaire<\/a>, named for its four questions, is one such example that may be used to screen patients quickly in a doctor&#8217;s office.<\/p>\n<blockquote class=\"templatequote\"><p>Two &#8220;yes&#8221; responses indicate that the respondent should be investigated further.<\/p>\n<p>The questionnaire asks the following questions:<\/p>\n<ol>\n<li>Have you ever felt you needed to\u00a0<b>C<\/b>ut down on your drinking?<\/li>\n<li>Have people\u00a0<b>A<\/b>nnoyed you by criticizing your drinking?<\/li>\n<li>Have you ever felt\u00a0<b>G<\/b>uilty about drinking?<\/li>\n<li>Have you ever felt you needed a drink first thing in the morning (<b>E<\/b>ye-opener) to steady your nerves or to get rid of a hangover?<sup id=\"cite_ref-113\" class=\"reference\"><\/sup><\/li>\n<\/ol>\n<\/blockquote>\n<dl>\n<dd>The CAGE questionnaire has demonstrated a high effectiveness in detecting alcohol-related problems; however, it has limitations in people with less severe alcohol-related problems, white women and college students.<sup id=\"cite_ref-115\" class=\"reference\"><\/sup><\/dd>\n<\/dl>\n<\/div>\n<dl><\/dl>\n<p>Other tests are sometimes used for the detection of alcohol dependence, such as the\u00a0<a title=\"Alcohol Dependence Data Questionnaire\" href=\"https:\/\/en.wikipedia.org\/wiki\/Alcohol_Dependence_Data_Questionnaire\">Alcohol Dependence Data Questionnaire<\/a>, which is a more sensitive diagnostic test than the\u00a0<a title=\"CAGE questionnaire\" href=\"https:\/\/en.wikipedia.org\/wiki\/CAGE_questionnaire\">CAGE questionnaire<\/a>. It helps distinguish a diagnosis of alcohol dependence from one of heavy alcohol use.<sup id=\"cite_ref-116\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-116\">[116]<\/a><\/sup>\u00a0The\u00a0<a class=\"mw-redirect\" title=\"Michigan Alcohol Screening Test\" href=\"https:\/\/en.wikipedia.org\/wiki\/Michigan_Alcohol_Screening_Test\">Michigan Alcohol Screening Test<\/a>\u00a0(MAST) is a screening tool for alcoholism widely used by courts to determine the appropriate sentencing for people convicted of alcohol-related offenses,<sup id=\"cite_ref-117\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-117\">[117]<\/a><\/sup>\u00a0<a title=\"Driving under the influence\" href=\"https:\/\/en.wikipedia.org\/wiki\/Driving_under_the_influence\">driving under the influence<\/a>\u00a0being the most common. The\u00a0<a title=\"Alcohol Use Disorders Identification Test\" href=\"https:\/\/en.wikipedia.org\/wiki\/Alcohol_Use_Disorders_Identification_Test\">Alcohol Use Disorders Identification Test<\/a>\u00a0(AUDIT), a screening questionnaire developed by the\u00a0<a title=\"World Health Organization\" href=\"https:\/\/en.wikipedia.org\/wiki\/World_Health_Organization\">World Health Organization<\/a>, is unique in that it has been validated in six countries and is used internationally. Like the CAGE questionnaire, it uses a simple set of questions \u2013 a high score earning a deeper investigation.<sup id=\"cite_ref-118\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-118\">[118]<\/a><\/sup>\u00a0The\u00a0<a class=\"mw-redirect\" title=\"Paddington Alcohol Test\" href=\"https:\/\/en.wikipedia.org\/wiki\/Paddington_Alcohol_Test\">Paddington Alcohol Test<\/a>\u00a0(PAT) was designed to screen for alcohol-related problems amongst those attending\u00a0<a class=\"mw-redirect\" title=\"Accident and Emergency department\" href=\"https:\/\/en.wikipedia.org\/wiki\/Accident_and_Emergency_department\">Accident and Emergency departments<\/a>. It concords well with the AUDIT questionnaire but is administered in a fifth of the time.<sup id=\"cite_ref-119\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-119\">[119]<\/a><\/sup><\/p>\n<h2><span id=\"Management\" class=\"mw-headline\">Management<\/span><\/h2>\n<p>Treatments are varied because there are multiple perspectives of alcoholism. Those who approach alcoholism as a medical condition or disease recommend differing treatments from, for instance, those who approach the condition as one of social choice. Most treatments focus on helping people discontinue their alcohol intake, followed up with life training and\/or social support to help them resist a return to alcohol use. Since alcoholism involves multiple factors which encourage a person to continue drinking, they must all be addressed to successfully prevent a relapse. An example of this kind of treatment is detoxification followed by a combination of supportive therapy, attendance at self-help groups, and ongoing development of coping mechanisms. Much of the treatment community for alcoholism supports an abstinence-based\u00a0<a title=\"Zero tolerance\" href=\"https:\/\/en.wikipedia.org\/wiki\/Zero_tolerance\">zero tolerance<\/a>\u00a0approach; however, some prefer a\u00a0<a title=\"Harm reduction\" href=\"https:\/\/en.wikipedia.org\/wiki\/Harm_reduction\">harm-reduction<\/a>\u00a0approach.<sup id=\"cite_ref-Gabbard_125-0\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-Gabbard-125\">[125]<\/a><\/sup><\/p>\n<h3><span id=\"Detoxification\" class=\"mw-headline\">Detoxification<\/span><\/h3>\n<div class=\"hatnote navigation-not-searchable\" role=\"note\">Main article:\u00a0<a title=\"Alcohol detoxification\" href=\"https:\/\/en.wikipedia.org\/wiki\/Alcohol_detoxification\">Alcohol detoxification<\/a><\/div>\n<p><a title=\"Alcohol detoxification\" href=\"https:\/\/en.wikipedia.org\/wiki\/Alcohol_detoxification\">Alcohol detoxification<\/a>\u00a0or &#8216;detox&#8217; for alcoholics is an abrupt stop of alcohol drinking coupled with the substitution of drugs, such as\u00a0<a class=\"mw-redirect\" title=\"Benzodiazepines\" href=\"https:\/\/en.wikipedia.org\/wiki\/Benzodiazepines\">benzodiazepines<\/a>, that have similar effects to prevent\u00a0<a title=\"Alcohol withdrawal syndrome\" href=\"https:\/\/en.wikipedia.org\/wiki\/Alcohol_withdrawal_syndrome\">alcohol withdrawal<\/a>. Individuals who are only at risk of mild to moderate withdrawal symptoms can be detoxified as outpatients. Individuals at risk of a severe withdrawal syndrome as well as those who have significant or acute comorbid conditions are generally treated as inpatients. Detoxification does not actually treat alcoholism, and it is necessary to follow up detoxification with an appropriate treatment program for alcohol dependence or alcohol use disorder to reduce the risk of relapse.<sup id=\"cite_ref-Blondell-2005_9-5\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-Blondell-2005-9\">[9]<\/a><\/sup>\u00a0Some symptoms of alcohol withdrawal such as depressed mood and anxiety typically take weeks or months to abate while other symptoms persist longer due to persisting neuroadaptations.<sup id=\"cite_ref-pmid20148778_69-2\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-pmid20148778-69\">[69]<\/a><\/sup>\u00a0Alcoholism has serious adverse effects on brain function; on average it takes one year of abstinence to recover from the cognitive deficits incurred by chronic alcohol misuse.<sup id=\"cite_ref-Stavro-2012_126-0\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-Stavro-2012-126\">[126]<\/a><\/sup><\/p>\n<h3><span id=\"Psychological\" class=\"mw-headline\">Psychological<\/span><\/h3>\n<div class=\"thumb tright\">\n<div class=\"thumbinner\">\n<div style=\"width: 230px\" class=\"wp-caption alignleft\"><a class=\"image\" href=\"https:\/\/en.wikipedia.org\/wiki\/File:Alcoholics_Anonymous_Regional_Service_Center_by_David_Shankbone.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"thumbimage\" src=\"https:\/\/upload.wikimedia.org\/wikipedia\/commons\/thumb\/3\/30\/Alcoholics_Anonymous_Regional_Service_Center_by_David_Shankbone.jpg\/220px-Alcoholics_Anonymous_Regional_Service_Center_by_David_Shankbone.jpg\" alt=\"\" width=\"220\" height=\"165\" \/><\/a><\/p>\n<p class=\"wp-caption-text\">A regional service center for\u00a0Alcoholics Anonymous.<\/p>\n<\/div>\n<div class=\"thumbcaption\">\n<div class=\"magnify\"><span style=\"font-size: 1rem;text-align: initial\">Various forms of\u00a0<\/span><a class=\"mw-redirect\" style=\"font-size: 1rem;text-align: initial\" title=\"Group therapy\" href=\"https:\/\/en.wikipedia.org\/wiki\/Group_therapy\">group therapy<\/a><span style=\"font-size: 1rem;text-align: initial\">\u00a0or\u00a0<\/span><a style=\"font-size: 1rem;text-align: initial\" title=\"Psychotherapy\" href=\"https:\/\/en.wikipedia.org\/wiki\/Psychotherapy\">psychotherapy<\/a><span style=\"font-size: 1rem;text-align: initial\">\u00a0can be used to deal with underlying psychological issues that are related to alcohol addiction, as well as provide relapse prevention skills. The mutual-help group-counseling approach is one of the most common ways of helping alcoholics maintain sobriety.<\/span><sup id=\"cite_ref-Morgan-Lopez-2006_8-2\" class=\"reference\" style=\"text-align: initial\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-Morgan-Lopez-2006-8\">[8]<\/a><\/sup><span style=\"font-size: 1rem;text-align: initial\">\u00a0<\/span><a style=\"font-size: 1rem;text-align: initial\" title=\"Alcoholics Anonymous\" href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholics_Anonymous\">Alcoholics Anonymous<\/a><span style=\"font-size: 1rem;text-align: initial\">\u00a0was one of the first organizations formed to provide mutual, nonprofessional counseling, and it is still the largest. Others include\u00a0<\/span><a style=\"font-size: 1rem;text-align: initial\" title=\"LifeRing Secular Recovery\" href=\"https:\/\/en.wikipedia.org\/wiki\/LifeRing_Secular_Recovery\">LifeRing Secular Recovery<\/a><span style=\"font-size: 1rem;text-align: initial\">,\u00a0<\/span><a style=\"font-size: 1rem;text-align: initial\" title=\"SMART Recovery\" href=\"https:\/\/en.wikipedia.org\/wiki\/SMART_Recovery\">SMART Recovery<\/a><span style=\"font-size: 1rem;text-align: initial\">,\u00a0<\/span><a style=\"font-size: 1rem;text-align: initial\" title=\"Women for Sobriety\" href=\"https:\/\/en.wikipedia.org\/wiki\/Women_for_Sobriety\">Women for Sobriety<\/a><span style=\"font-size: 1rem;text-align: initial\">, and\u00a0<\/span><a style=\"font-size: 1rem;text-align: initial\" title=\"Secular Organizations for Sobriety\" href=\"https:\/\/en.wikipedia.org\/wiki\/Secular_Organizations_for_Sobriety\">Secular Organizations for Sobriety<\/a><span style=\"font-size: 1rem;text-align: initial\">.<\/span><sup id=\"cite_ref-127\" class=\"reference\" style=\"text-align: initial\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-127\">[127]<\/a><\/sup><span style=\"font-size: 1rem;text-align: initial\">\u00a0Alcoholics Anonymous and\u00a0<\/span><a style=\"font-size: 1rem;text-align: initial\" title=\"Twelve-step program\" href=\"https:\/\/en.wikipedia.org\/wiki\/Twelve-step_program\">twelve-step programs<\/a><span style=\"font-size: 1rem;text-align: initial\">\u00a0appear more effective than cognitive behavioral therapy or abstinence.<\/span><sup id=\"cite_ref-coch2020_128-0\" class=\"reference\" style=\"text-align: initial\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-coch2020-128\">[128]<\/a><\/sup><\/div>\n<\/div>\n<\/div>\n<\/div>\n<h3><\/h3>\n<h3><span id=\"Moderate_drinking\" class=\"mw-headline\">Moderate drinking<\/span><\/h3>\n<p>Rationing and moderation programs such as\u00a0<a title=\"Moderation Management\" href=\"https:\/\/en.wikipedia.org\/wiki\/Moderation_Management\">Moderation Management<\/a>\u00a0and DrinkWise do not mandate complete abstinence. While most alcoholics are unable to limit their drinking in this way, some return to moderate drinking. A 2002 US study by the\u00a0<a title=\"National Institute on Alcohol Abuse and Alcoholism\" href=\"https:\/\/en.wikipedia.org\/wiki\/National_Institute_on_Alcohol_Abuse_and_Alcoholism\">National Institute on Alcohol Abuse and Alcoholism<\/a>\u00a0(NIAAA) showed that 17.7 percent of individuals diagnosed as alcohol dependent more than one year prior returned to low-risk drinking. This group, however, showed fewer initial symptoms of dependency.<sup id=\"cite_ref-DAWSON2005_129-0\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-DAWSON2005-129\">[129]<\/a><\/sup><\/p>\n<p>A follow-up study, using the same subjects that were judged to be in remission in 2001\u20132002, examined the rates of return to problem drinking in 2004\u20132005. The study found abstinence from alcohol was the most stable form of remission for recovering alcoholics.<sup id=\"cite_ref-DAWSON2007_130-0\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-DAWSON2007-130\">[130]<\/a><\/sup>\u00a0There was also a 1973 study showing chronic alcoholics drinking moderately again,<sup id=\"cite_ref-Sobell1973_131-0\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-Sobell1973-131\">[131]<\/a><\/sup>\u00a0but a 1982 follow-up showed that 95% of subjects were not able to moderately drink over the long term.<sup id=\"cite_ref-Pendery1982_132-0\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-Pendery1982-132\">[132]<\/a><\/sup><sup id=\"cite_ref-Pendery1982NYT_133-0\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-Pendery1982NYT-133\">[133]<\/a><\/sup>\u00a0Another study was a long-term (60 year) follow-up of two groups of alcoholic men which concluded that &#8220;return to controlled drinking rarely persisted for much more than a decade without relapse or evolution into abstinence.&#8221;<sup id=\"cite_ref-VAILLANT2003_134-0\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-VAILLANT2003-134\">[134]<\/a><\/sup>\u00a0Internet based measures appear to be useful at least in the short term.<sup id=\"cite_ref-135\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-135\">[135]<\/a><\/sup><\/p>\n<h3><span id=\"Medications\" class=\"mw-headline\">Medications<\/span><\/h3>\n<h2><span id=\"Disulfiram-like_drug\" class=\"mw-headline\"><a title=\"Disulfiram-like drug\" href=\"https:\/\/en.wikipedia.org\/wiki\/Disulfiram-like_drug\">Disulfiram-like drug<\/a><\/span><\/h2>\n<p>In the United States there are four approved medications for alcoholism: acamprosate, two methods of using naltrexone and disulfiram.<sup id=\"cite_ref-136\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-136\">[136]<\/a><\/sup><\/p>\n<ul>\n<li><a title=\"Acamprosate\" href=\"https:\/\/en.wikipedia.org\/wiki\/Acamprosate\">Acamprosate<\/a>\u00a0may stabilise the brain chemistry that is altered due to alcohol dependence via antagonising the actions of\u00a0<a class=\"mw-redirect\" title=\"Glutamate\" href=\"https:\/\/en.wikipedia.org\/wiki\/Glutamate\">glutamate<\/a>, a neurotransmitter which is hyperactive in the\u00a0<a class=\"mw-redirect\" title=\"Post-withdrawal\" href=\"https:\/\/en.wikipedia.org\/wiki\/Post-withdrawal\">post-withdrawal<\/a>\u00a0phase.<sup id=\"cite_ref-137\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-137\">[137]<\/a><\/sup>\u00a0By reducing excessive NMDA activity which occurs at the onset of alcohol withdrawal, acamprosate can reduce or prevent alcohol withdrawal related neurotoxicity.<sup id=\"cite_ref-pmid20201812_138-0\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-pmid20201812-138\">[138]<\/a><\/sup>\u00a0Acamprosate reduces the risk of relapse amongst alcohol-dependent persons.<sup id=\"cite_ref-139\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-139\">[139]<\/a><\/sup><sup id=\"cite_ref-JAMA2014_140-0\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-JAMA2014-140\">[140]<\/a><\/sup><\/li>\n<li><a title=\"Naltrexone\" href=\"https:\/\/en.wikipedia.org\/wiki\/Naltrexone\">Naltrexone<\/a>\u00a0is a\u00a0<a class=\"mw-redirect\" title=\"Competitive antagonist\" href=\"https:\/\/en.wikipedia.org\/wiki\/Competitive_antagonist\">competitive antagonist<\/a>\u00a0for opioid receptors, effectively blocking the effects of\u00a0<a class=\"mw-redirect\" title=\"Endorphin\" href=\"https:\/\/en.wikipedia.org\/wiki\/Endorphin\">endorphins<\/a>\u00a0and\u00a0<a title=\"Opioid\" href=\"https:\/\/en.wikipedia.org\/wiki\/Opioid\">opioids<\/a>. Naltrexone is used to decrease cravings for alcohol and encourage abstinence. Alcohol causes the body to release endorphins, which in turn release dopamine and activate the reward pathways; hence in the body reduces the pleasurable effects from consuming alcohol.<sup id=\"cite_ref-141\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-141\">[141]<\/a><\/sup>\u00a0Evidence supports a reduced risk of relapse among alcohol-dependent persons and a decrease in excessive drinking.<sup id=\"cite_ref-JAMA2014_140-1\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-JAMA2014-140\">[140]<\/a><\/sup>\u00a0<a title=\"Nalmefene\" href=\"https:\/\/en.wikipedia.org\/wiki\/Nalmefene\">Nalmefene<\/a>\u00a0also appears effective and works in a similar manner.<sup id=\"cite_ref-JAMA2014_140-2\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-JAMA2014-140\">[140]<\/a><\/sup><\/li>\n<li><span id=\"The_Sinclair_Method\" class=\"anchor\"><\/span>The Sinclair method is another approach to using naltrexone or other\u00a0<a title=\"Opioid antagonist\" href=\"https:\/\/en.wikipedia.org\/wiki\/Opioid_antagonist\">opioid antagonists<\/a>\u00a0to treat alcoholism by having the person take the medication about an hour before they drink alcohol\u00a0<i>and only then<\/i>.<sup id=\"cite_ref-142\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-142\">[142]<\/a><\/sup><sup id=\"cite_ref-Sin2001_143-0\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-Sin2001-143\">[143]<\/a><\/sup>\u00a0The medication blocks the\u00a0<a class=\"mw-redirect\" title=\"Positive reinforcement\" href=\"https:\/\/en.wikipedia.org\/wiki\/Positive_reinforcement\">positive reinforcement<\/a>\u00a0effects of ethanol and hypothetically allows the person to stop drinking or drink less.<sup id=\"cite_ref-Sin2001_143-1\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-Sin2001-143\">[143]<\/a><\/sup><\/li>\n<li><a title=\"Disulfiram\" href=\"https:\/\/en.wikipedia.org\/wiki\/Disulfiram\">Disulfiram<\/a>\u00a0prevents the elimination of\u00a0<a title=\"Acetaldehyde\" href=\"https:\/\/en.wikipedia.org\/wiki\/Acetaldehyde\">acetaldehyde<\/a>, a chemical the body produces when breaking down ethanol. Acetaldehyde itself is the cause of many\u00a0<a title=\"Hangover\" href=\"https:\/\/en.wikipedia.org\/wiki\/Hangover\">hangover<\/a>\u00a0symptoms from alcohol use. The overall effect is discomfort when alcohol is ingested: an extremely fast-acting and long-lasting, uncomfortable hangover.<\/li>\n<\/ul>\n<p>Several other drugs are also used and many are under investigation.<\/p>\n<ul>\n<li><a class=\"mw-redirect\" title=\"Benzodiazepines\" href=\"https:\/\/en.wikipedia.org\/wiki\/Benzodiazepines\">Benzodiazepines<\/a>, while useful in the management of acute alcohol withdrawal, if used long-term can cause a worse outcome in alcoholism. Alcoholics on chronic benzodiazepines have a lower rate of achieving abstinence from alcohol than those not taking benzodiazepines. This class of drugs is commonly prescribed to alcoholics for insomnia or anxiety management.<sup id=\"cite_ref-144\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-144\">[144]<\/a><\/sup>\u00a0Initiating prescriptions of benzodiazepines or sedative-hypnotics in individuals in recovery has a high rate of relapse with one author reporting more than a quarter of people relapsed after being prescribed sedative-hypnotics. Those who are long-term users of benzodiazepines should not be withdrawn rapidly, as severe anxiety and panic may develop, which are known risk factors for alcohol use disorder relapse. Taper regimes of 6\u201312 months have been found to be the most successful, with reduced intensity of withdrawal.<sup id=\"cite_ref-145\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-145\">[145]<\/a><\/sup><sup id=\"cite_ref-146\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-146\">[146]<\/a><\/sup><\/li>\n<li><a title=\"Calcium carbimide\" href=\"https:\/\/en.wikipedia.org\/wiki\/Calcium_carbimide\">Calcium carbimide<\/a>\u00a0works in the same way as disulfiram; it has an advantage in that the occasional adverse effects of disulfiram,\u00a0<a title=\"Hepatotoxicity\" href=\"https:\/\/en.wikipedia.org\/wiki\/Hepatotoxicity\">hepatotoxicity<\/a>\u00a0and drowsiness, do not occur with calcium carbimide.<sup id=\"cite_ref-147\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-147\">[147]<\/a><\/sup><\/li>\n<li><a title=\"Ondansetron\" href=\"https:\/\/en.wikipedia.org\/wiki\/Ondansetron\">Ondansetron<\/a>\u00a0and\u00a0<a title=\"Topiramate\" href=\"https:\/\/en.wikipedia.org\/wiki\/Topiramate\">topiramate<\/a>\u00a0are supported by tentative evidence in people with certain genetics.<sup id=\"cite_ref-Soy2017_148-0\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-Soy2017-148\">[148]<\/a><\/sup><sup id=\"cite_ref-Cs2017_149-0\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-Cs2017-149\">[149]<\/a><\/sup>\u00a0Evidence for ondansetron is more in those who have just begun having problems with alcohol.<sup id=\"cite_ref-Soy2017_148-1\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-Soy2017-148\">[148]<\/a><\/sup>\u00a0Topiramate is a derivative of the naturally occurring sugar monosaccharide D-fructose. Review articles characterize topiramate as showing &#8220;encouraging&#8221;,<sup id=\"cite_ref-Soy2017_148-2\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-Soy2017-148\">[148]<\/a><\/sup>\u00a0&#8220;promising&#8221;,<sup id=\"cite_ref-Soy2017_148-3\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-Soy2017-148\">[148]<\/a><\/sup>\u00a0&#8220;efficacious&#8221;,<sup id=\"cite_ref-150\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-150\">[150]<\/a><\/sup>\u00a0and &#8220;insufficient&#8221;<sup id=\"cite_ref-151\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-151\">[151]<\/a><\/sup>\u00a0evidence in the treatment of alcohol use disorders.<\/li>\n<\/ul>\n<p>Evidence does not support the use of\u00a0<a class=\"mw-redirect\" title=\"Selective serotonin reuptake inhibitors\" href=\"https:\/\/en.wikipedia.org\/wiki\/Selective_serotonin_reuptake_inhibitors\">selective serotonin reuptake inhibitors<\/a>\u00a0(SSRIs),\u00a0<a class=\"mw-redirect\" title=\"Tricyclic antidepressants\" href=\"https:\/\/en.wikipedia.org\/wiki\/Tricyclic_antidepressants\">tricyclic antidepressants<\/a>\u00a0(TCAs),\u00a0<a title=\"Antipsychotic\" href=\"https:\/\/en.wikipedia.org\/wiki\/Antipsychotic\">antipsychotics<\/a>, or\u00a0<a title=\"Gabapentin\" href=\"https:\/\/en.wikipedia.org\/wiki\/Gabapentin\">gabapentin<\/a>.<sup id=\"cite_ref-JAMA2014_140-3\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-JAMA2014-140\">[140]<\/a><\/sup><\/p>\n<h3><span id=\"Dual_addictions_and_dependences\" class=\"mw-headline\">Dual addictions and dependences<\/span><\/h3>\n<p>Alcoholics may also require treatment for other psychotropic\u00a0<a class=\"mw-redirect\" title=\"Drug addiction\" href=\"https:\/\/en.wikipedia.org\/wiki\/Drug_addiction\">drug addictions<\/a>\u00a0and\u00a0<a class=\"mw-redirect\" title=\"Drug dependence\" href=\"https:\/\/en.wikipedia.org\/wiki\/Drug_dependence\">drug dependences<\/a>. The most common dual dependence syndrome with alcohol dependence is\u00a0<a title=\"Benzodiazepine dependence\" href=\"https:\/\/en.wikipedia.org\/wiki\/Benzodiazepine_dependence\">benzodiazepine dependence<\/a>, with studies showing 10\u201320 percent of alcohol-dependent individuals had problems of dependence and\/or misuse problems of benzodiazepine drugs such as\u00a0<a title=\"Diazepam\" href=\"https:\/\/en.wikipedia.org\/wiki\/Diazepam\">diazepam<\/a>\u00a0or\u00a0<a title=\"Clonazepam\" href=\"https:\/\/en.wikipedia.org\/wiki\/Clonazepam\">clonazepam<\/a>. These drugs are, like alcohol,\u00a0<a title=\"Depressant\" href=\"https:\/\/en.wikipedia.org\/wiki\/Depressant\">depressants<\/a>. Benzodiazepines may be used legally, if they are prescribed by doctors for anxiety problems or other mood disorders, or they may be purchased as\u00a0<a class=\"mw-redirect\" title=\"Illegal drugs\" href=\"https:\/\/en.wikipedia.org\/wiki\/Illegal_drugs\">illegal drugs<\/a>. Benzodiazepine use increases cravings for alcohol and the volume of alcohol consumed by problem drinkers.<sup id=\"cite_ref-152\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-152\">[152]<\/a><\/sup>\u00a0Benzodiazepine dependency requires careful reduction in dosage to avoid\u00a0<a title=\"Benzodiazepine withdrawal syndrome\" href=\"https:\/\/en.wikipedia.org\/wiki\/Benzodiazepine_withdrawal_syndrome\">benzodiazepine withdrawal syndrome<\/a>\u00a0and other health consequences. Dependence on other sedative-hypnotics such as\u00a0<a title=\"Zolpidem\" href=\"https:\/\/en.wikipedia.org\/wiki\/Zolpidem\">zolpidem<\/a>\u00a0and\u00a0<a title=\"Zopiclone\" href=\"https:\/\/en.wikipedia.org\/wiki\/Zopiclone\">zopiclone<\/a>\u00a0as well as\u00a0<a title=\"Opiate\" href=\"https:\/\/en.wikipedia.org\/wiki\/Opiate\">opiates<\/a>\u00a0and illegal drugs is common in alcoholics. Alcohol itself is a sedative-hypnotic and is cross-tolerant with other sedative-hypnotics such as\u00a0<a title=\"Barbiturate\" href=\"https:\/\/en.wikipedia.org\/wiki\/Barbiturate\">barbiturates<\/a>, benzodiazepines and\u00a0<a title=\"Nonbenzodiazepine\" href=\"https:\/\/en.wikipedia.org\/wiki\/Nonbenzodiazepine\">nonbenzodiazepines<\/a>. Dependence upon and withdrawal from sedative-hypnotics can be medically severe and, as with alcohol withdrawal, there is a risk of\u00a0<a title=\"Psychosis\" href=\"https:\/\/en.wikipedia.org\/wiki\/Psychosis\">psychosis<\/a>\u00a0or\u00a0<a title=\"Seizure\" href=\"https:\/\/en.wikipedia.org\/wiki\/Seizure\">seizures<\/a>\u00a0if not properly managed.<sup id=\"cite_ref-dolpdaa_153-0\" class=\"reference\"><a href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism#cite_note-dolpdaa-153\">[153]<\/a><\/sup><\/p>\n\n\t\t\t <section class=\"citations-section\" role=\"contentinfo\">\n\t\t\t <h3>Candela Citations<\/h3>\n\t\t\t\t\t <div>\n\t\t\t\t\t\t <div id=\"citation-list-196\">\n\t\t\t\t\t\t\t <div class=\"licensing\"><div class=\"license-attribution-dropdown-subheading\">Public domain content<\/div><ul class=\"citation-list\"><li>Alcoholism. <strong>Provided by<\/strong>: Wikimedia, inc. <strong>Located at<\/strong>: <a target=\"_blank\" href=\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism\">https:\/\/en.wikipedia.org\/wiki\/Alcoholism<\/a>. <strong>License<\/strong>: <em><a target=\"_blank\" rel=\"license\" href=\"https:\/\/creativecommons.org\/licenses\/by-sa\/4.0\/\">CC BY-SA: Attribution-ShareAlike<\/a><\/em><\/li><\/ul><\/div>\n\t\t\t\t\t\t <\/div>\n\t\t\t\t\t <\/div>\n\t\t\t <\/section>","protected":false},"author":142337,"menu_order":4,"template":"","meta":{"_candela_citation":"[{\"type\":\"pd\",\"description\":\"Alcoholism\",\"author\":\"\",\"organization\":\"Wikimedia, inc\",\"url\":\"https:\/\/en.wikipedia.org\/wiki\/Alcoholism\",\"project\":\"\",\"license\":\"cc-by-sa\",\"license_terms\":\"\"}]","CANDELA_OUTCOMES_GUID":"","pb_show_title":"on","pb_short_title":"","pb_subtitle":"","pb_authors":[],"pb_section_license":""},"chapter-type":[],"contributor":[],"license":[],"class_list":["post-196","chapter","type-chapter","status-publish","hentry"],"part":91,"_links":{"self":[{"href":"https:\/\/courses.lumenlearning.com\/suny-hvcc-healthpsychology\/wp-json\/pressbooks\/v2\/chapters\/196","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/courses.lumenlearning.com\/suny-hvcc-healthpsychology\/wp-json\/pressbooks\/v2\/chapters"}],"about":[{"href":"https:\/\/courses.lumenlearning.com\/suny-hvcc-healthpsychology\/wp-json\/wp\/v2\/types\/chapter"}],"author":[{"embeddable":true,"href":"https:\/\/courses.lumenlearning.com\/suny-hvcc-healthpsychology\/wp-json\/wp\/v2\/users\/142337"}],"version-history":[{"count":2,"href":"https:\/\/courses.lumenlearning.com\/suny-hvcc-healthpsychology\/wp-json\/pressbooks\/v2\/chapters\/196\/revisions"}],"predecessor-version":[{"id":200,"href":"https:\/\/courses.lumenlearning.com\/suny-hvcc-healthpsychology\/wp-json\/pressbooks\/v2\/chapters\/196\/revisions\/200"}],"part":[{"href":"https:\/\/courses.lumenlearning.com\/suny-hvcc-healthpsychology\/wp-json\/pressbooks\/v2\/parts\/91"}],"metadata":[{"href":"https:\/\/courses.lumenlearning.com\/suny-hvcc-healthpsychology\/wp-json\/pressbooks\/v2\/chapters\/196\/metadata\/"}],"wp:attachment":[{"href":"https:\/\/courses.lumenlearning.com\/suny-hvcc-healthpsychology\/wp-json\/wp\/v2\/media?parent=196"}],"wp:term":[{"taxonomy":"chapter-type","embeddable":true,"href":"https:\/\/courses.lumenlearning.com\/suny-hvcc-healthpsychology\/wp-json\/pressbooks\/v2\/chapter-type?post=196"},{"taxonomy":"contributor","embeddable":true,"href":"https:\/\/courses.lumenlearning.com\/suny-hvcc-healthpsychology\/wp-json\/wp\/v2\/contributor?post=196"},{"taxonomy":"license","embeddable":true,"href":"https:\/\/courses.lumenlearning.com\/suny-hvcc-healthpsychology\/wp-json\/wp\/v2\/license?post=196"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}