{"id":327,"date":"2016-11-04T03:33:08","date_gmt":"2016-11-04T03:33:08","guid":{"rendered":"https:\/\/courses.lumenlearning.com\/microbiology\/?post_type=chapter&#038;p=327"},"modified":"2016-11-08T17:34:27","modified_gmt":"2016-11-08T17:34:27","slug":"introduction-to-microbial-biochemistry","status":"publish","type":"chapter","link":"https:\/\/courses.lumenlearning.com\/suny-microbiology\/chapter\/introduction-to-microbial-biochemistry\/","title":{"raw":"Introduction to Microbial Biochemistry","rendered":"Introduction to Microbial Biochemistry"},"content":{"raw":"The earth is estimated to be 4.6 billion years old, but for the first 2 billion years, the atmosphere lacked oxygen, without which the earth could not support life as we know it. One hypothesis about how life emerged on earth involves the concept of a \"primordial soup.\" This idea proposes that life began in a body of water when metals and gases from the atmosphere combined with a source of energy, such as lightning or ultraviolet light, to form the carbon compounds that are the chemical building blocks of life. In 1952, Stanley <span class=\"no-emphasis\" data-type=\"term\">Miller<\/span> (1930\u20132007), a graduate student at the University of Chicago, and his professor Harold <span class=\"no-emphasis\" data-type=\"term\">Urey<\/span> (1893\u20131981), set out to confirm this hypothesis in a now-famous experiment. Miller and Urey combined what they believed to be the major components of the earth\u2019s early atmosphere\u2014water (H<sub>2<\/sub>O), methane (CH<sub>4<\/sub>), hydrogen (H<sub>2<\/sub>), and ammonia (NH<sub>3<\/sub>)\u2014and sealed them in a sterile flask. Next, they heated the flask to produce water vapor and passed electric sparks through the mixture to mimic lightning in the atmosphere (Figure 1). When they analyzed the contents of the flask a week later, they found amino acids, the structural units of proteins\u2014molecules essential to the function of all organisms.\r\n\r\n[caption id=\"\" align=\"aligncenter\" width=\"1300\"]<img src=\"https:\/\/s3-us-west-2.amazonaws.com\/courses-images\/wp-content\/uploads\/sites\/1094\/2016\/11\/03154643\/OSC_Microbio_07_00_splash.jpg\" alt=\"Photo of Stanley Miller. Diagram of the Miller-Urey experiment. A flask of water (to simulate the ocean) is heated. This is connected via glass tubing in a closed loop to: a vacuum pup, a flask containing gases (water, methane, hydrogen, ammonia) and an electric spark (to stimulate lightning), and final to a condenser that cools the water. The cooled water contains organic compounds.\" width=\"1300\" height=\"529\" data-media-type=\"image\/jpeg\" \/> Figure 1. Scientist Stanley Miller (pictured) and Harold Urey demonstrated that organic compounds may have originated naturally from inorganic matter. The Miller-Urey experiment illustrated here simulated the effects of lightning on chemical compounds found in the earth\u2019s early atmosphere. The resulting reactions yielded amino acids, the chemical building blocks of proteins. (credit \"photo\": modification of work by NASA; credit \"illustration\": modification of work by Courtney Harrington)[\/caption]","rendered":"<p>The earth is estimated to be 4.6 billion years old, but for the first 2 billion years, the atmosphere lacked oxygen, without which the earth could not support life as we know it. One hypothesis about how life emerged on earth involves the concept of a &#8220;primordial soup.&#8221; This idea proposes that life began in a body of water when metals and gases from the atmosphere combined with a source of energy, such as lightning or ultraviolet light, to form the carbon compounds that are the chemical building blocks of life. In 1952, Stanley <span class=\"no-emphasis\" data-type=\"term\">Miller<\/span> (1930\u20132007), a graduate student at the University of Chicago, and his professor Harold <span class=\"no-emphasis\" data-type=\"term\">Urey<\/span> (1893\u20131981), set out to confirm this hypothesis in a now-famous experiment. Miller and Urey combined what they believed to be the major components of the earth\u2019s early atmosphere\u2014water (H<sub>2<\/sub>O), methane (CH<sub>4<\/sub>), hydrogen (H<sub>2<\/sub>), and ammonia (NH<sub>3<\/sub>)\u2014and sealed them in a sterile flask. Next, they heated the flask to produce water vapor and passed electric sparks through the mixture to mimic lightning in the atmosphere (Figure 1). When they analyzed the contents of the flask a week later, they found amino acids, the structural units of proteins\u2014molecules essential to the function of all organisms.<\/p>\n<div style=\"width: 1310px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/s3-us-west-2.amazonaws.com\/courses-images\/wp-content\/uploads\/sites\/1094\/2016\/11\/03154643\/OSC_Microbio_07_00_splash.jpg\" alt=\"Photo of Stanley Miller. Diagram of the Miller-Urey experiment. A flask of water (to simulate the ocean) is heated. This is connected via glass tubing in a closed loop to: a vacuum pup, a flask containing gases (water, methane, hydrogen, ammonia) and an electric spark (to stimulate lightning), and final to a condenser that cools the water. The cooled water contains organic compounds.\" width=\"1300\" height=\"529\" data-media-type=\"image\/jpeg\" \/><\/p>\n<p class=\"wp-caption-text\">Figure 1. Scientist Stanley Miller (pictured) and Harold Urey demonstrated that organic compounds may have originated naturally from inorganic matter. The Miller-Urey experiment illustrated here simulated the effects of lightning on chemical compounds found in the earth\u2019s early atmosphere. The resulting reactions yielded amino acids, the chemical building blocks of proteins. (credit &#8220;photo&#8221;: modification of work by NASA; credit &#8220;illustration&#8221;: modification of work by Courtney Harrington)<\/p>\n<\/div>\n\n\t\t\t <section class=\"citations-section\" role=\"contentinfo\">\n\t\t\t <h3>Candela Citations<\/h3>\n\t\t\t\t\t <div>\n\t\t\t\t\t\t <div id=\"citation-list-327\">\n\t\t\t\t\t\t\t <div class=\"licensing\"><div class=\"license-attribution-dropdown-subheading\">CC licensed content, Shared previously<\/div><ul class=\"citation-list\"><li>OpenStax Microbiology. <strong>Provided by<\/strong>: OpenStax CNX. <strong>Located at<\/strong>: <a target=\"_blank\" href=\"http:\/\/cnx.org\/contents\/e42bd376-624b-4c0f-972f-e0c57998e765@4.2\">http:\/\/cnx.org\/contents\/e42bd376-624b-4c0f-972f-e0c57998e765@4.2<\/a>. <strong>License<\/strong>: <em><a target=\"_blank\" rel=\"license\" href=\"https:\/\/creativecommons.org\/licenses\/by\/4.0\/\">CC BY: Attribution<\/a><\/em>. <strong>License Terms<\/strong>: Download for free at http:\/\/cnx.org\/contents\/e42bd376-624b-4c0f-972f-e0c57998e765@4.2<\/li><\/ul><\/div>\n\t\t\t\t\t\t <\/div>\n\t\t\t\t\t <\/div>\n\t\t\t <\/section>","protected":false},"author":17,"menu_order":1,"template":"","meta":{"_candela_citation":"[{\"type\":\"cc\",\"description\":\"OpenStax Microbiology\",\"author\":\"\",\"organization\":\"OpenStax CNX\",\"url\":\"http:\/\/cnx.org\/contents\/e42bd376-624b-4c0f-972f-e0c57998e765@4.2\",\"project\":\"\",\"license\":\"cc-by\",\"license_terms\":\"Download for free at http:\/\/cnx.org\/contents\/e42bd376-624b-4c0f-972f-e0c57998e765@4.2\"}]","CANDELA_OUTCOMES_GUID":"","pb_show_title":"on","pb_short_title":"","pb_subtitle":"","pb_authors":[],"pb_section_license":""},"chapter-type":[],"contributor":[],"license":[],"class_list":["post-327","chapter","type-chapter","status-publish","hentry"],"part":325,"_links":{"self":[{"href":"https:\/\/courses.lumenlearning.com\/suny-microbiology\/wp-json\/pressbooks\/v2\/chapters\/327","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/courses.lumenlearning.com\/suny-microbiology\/wp-json\/pressbooks\/v2\/chapters"}],"about":[{"href":"https:\/\/courses.lumenlearning.com\/suny-microbiology\/wp-json\/wp\/v2\/types\/chapter"}],"author":[{"embeddable":true,"href":"https:\/\/courses.lumenlearning.com\/suny-microbiology\/wp-json\/wp\/v2\/users\/17"}],"version-history":[{"count":4,"href":"https:\/\/courses.lumenlearning.com\/suny-microbiology\/wp-json\/pressbooks\/v2\/chapters\/327\/revisions"}],"predecessor-version":[{"id":1400,"href":"https:\/\/courses.lumenlearning.com\/suny-microbiology\/wp-json\/pressbooks\/v2\/chapters\/327\/revisions\/1400"}],"part":[{"href":"https:\/\/courses.lumenlearning.com\/suny-microbiology\/wp-json\/pressbooks\/v2\/parts\/325"}],"metadata":[{"href":"https:\/\/courses.lumenlearning.com\/suny-microbiology\/wp-json\/pressbooks\/v2\/chapters\/327\/metadata\/"}],"wp:attachment":[{"href":"https:\/\/courses.lumenlearning.com\/suny-microbiology\/wp-json\/wp\/v2\/media?parent=327"}],"wp:term":[{"taxonomy":"chapter-type","embeddable":true,"href":"https:\/\/courses.lumenlearning.com\/suny-microbiology\/wp-json\/pressbooks\/v2\/chapter-type?post=327"},{"taxonomy":"contributor","embeddable":true,"href":"https:\/\/courses.lumenlearning.com\/suny-microbiology\/wp-json\/wp\/v2\/contributor?post=327"},{"taxonomy":"license","embeddable":true,"href":"https:\/\/courses.lumenlearning.com\/suny-microbiology\/wp-json\/wp\/v2\/license?post=327"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}