{"id":1961,"date":"2018-03-21T16:14:12","date_gmt":"2018-03-21T16:14:12","guid":{"rendered":"https:\/\/courses.lumenlearning.com\/suny-orgbiochemistry\/chapter\/amino-acids-proteins-and-enzymes\/"},"modified":"2018-12-03T17:03:50","modified_gmt":"2018-12-03T17:03:50","slug":"introduction-18","status":"publish","type":"chapter","link":"https:\/\/courses.lumenlearning.com\/suny-monroecc-orgbiochemistry\/chapter\/introduction-18\/","title":{"raw":"Introduction","rendered":"Introduction"},"content":{"raw":"
\r\n
\u00a0\u00a0Chapter 18<\/span> Amino Acids, Proteins, and Enzymes<\/span><\/div>\r\n<\/div>\r\n
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\r\n
\r\n
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Opening Essay<\/h3>\r\n

The 1923 Nobel Prize in Medicine or Physiology was awarded to Frederick Grant Banting and John James Richard Macleod for their discovery of the protein insulin<\/em>. In 1958, the Nobel Prize in Chemistry was awarded to Frederick Sanger for his discoveries concerning the structure of proteins and, in particular, the structure of insulin. What is so important about insulin that two Nobel Prizes have been awarded for work on this protein?<\/p>\r\n

Insulin is a hormone that is synthesized in the pancreas.\u00a0 Insulin stimulates the transport of glucose into cells throughout the body and the storage of glucose as glycogen. People with diabetes do not produce insulin or use it properly. The isolation of insulin in 1921 led to the first effective treatment for these individuals.<\/p>\r\n\r\n

\r\n\r\n[caption id=\"\" align=\"aligncenter\" width=\"2700\"]\"image\" Figure 18.1 An Insulin Pump <\/em>[\/caption]\r\n\r\n<\/div>\r\n<\/div>\r\n

<\/p>\r\n\r\n<\/div>\r\n

Proteins<\/span>\u00a0may be defined as compounds of high molar mass consisting largely or entirely of chains of amino acids. Their masses range from several thousand to several million daltons (Da). In addition to carbon, hydrogen, and oxygen atoms, all proteins contain nitrogen and sulfur atoms, and many also contain phosphorus atoms and traces of other elements. Proteins serve a variety of roles in living organisms and are often classified by these biological roles, which are summarized in <\/span>Table 18.1 \"Classification of Proteins by Biological Function\"<\/a>. Muscle tissue is largely protein, as are skin and hair. Proteins are present in the blood, in the brain, and even in tooth enamel. Each type of cell in our bodies makes its own specialized proteins, as well as proteins common to all or most cells.<\/span><\/p>\r\n\r\n<\/div>\r\n

\r\n
\r\n

Note<\/h3>\r\n

The dalton<\/em> is a unit of mass used by biochemists and biologists. It is equivalent to the atomic mass unit. A 30,000 Da protein has a molar mass of 30,000 u.<\/p>\r\n\r\n<\/div>\r\n<\/div>\r\n

\r\n

Table 18.1<\/span> Classification of Proteins by Biological Function<\/p>\r\n\r\n\r\n\r\n\r\n\r\n\r\n\r\n\r\n\r\n\r\n\r\n\r\n
Classification<\/th>\r\nBiological Function<\/th>\r\nExample<\/th>\r\n<\/tr>\r\n<\/thead>\r\n
enzymes<\/td>\r\ncatalyze and provide specificity to\u00a0 biological reactions<\/td>\r\n\u03b1-Amylase catalyzes the hydrolysis of starch and glycogen.<\/td>\r\n<\/tr>\r\n
structural<\/td>\r\nprovide strength and form<\/td>\r\nKeratin is the primary protein of hair and wool.<\/td>\r\n<\/tr>\r\n
contractile<\/td>\r\nmuscle contraction; cell division<\/td>\r\nMyosin is one protein needed for the contraction of muscles.<\/td>\r\n<\/tr>\r\n
transport<\/td>\r\ntransport substances from one place to another<\/td>\r\nHemoglobin transports oxygen from the lungs throughout the body.<\/td>\r\n<\/tr>\r\n
regulatory<\/td>\r\nregulate the functioning of other proteins<\/td>\r\nInsulin regulates the activity of specific enzymes in the body.<\/td>\r\n<\/tr>\r\n
storage<\/td>\r\nprovide storage of essential nutrients<\/td>\r\nOvalbumin stores amino acids in the egg white that will be used by the developing bird.<\/td>\r\n<\/tr>\r\n
protection<\/td>\r\nprotect cells or the organism from foreign substances<\/td>\r\nImmunoglobulins recognize and tag foreign molecules.<\/td>\r\n<\/tr>\r\n<\/tbody>\r\n<\/table>\r\n<\/div>\r\n

We begin our study of proteins by looking at the properties and reactions of amino acids, which is followed by a discussion of how amino acids link covalently to form peptides and proteins. We end the chapter with a discussion of enzymes\u2014the proteins that act as catalysts in the body.<\/p>\r\n\r\n<\/div>\r\n<\/div>","rendered":"

\n
\u00a0\u00a0Chapter 18<\/span> Amino Acids, Proteins, and Enzymes<\/span><\/div>\n<\/div>\n
\n
\n
\n
\n
\n

Opening Essay<\/h3>\n

The 1923 Nobel Prize in Medicine or Physiology was awarded to Frederick Grant Banting and John James Richard Macleod for their discovery of the protein insulin<\/em>. In 1958, the Nobel Prize in Chemistry was awarded to Frederick Sanger for his discoveries concerning the structure of proteins and, in particular, the structure of insulin. What is so important about insulin that two Nobel Prizes have been awarded for work on this protein?<\/p>\n

Insulin is a hormone that is synthesized in the pancreas.\u00a0 Insulin stimulates the transport of glucose into cells throughout the body and the storage of glucose as glycogen. People with diabetes do not produce insulin or use it properly. The isolation of insulin in 1921 led to the first effective treatment for these individuals.<\/p>\n

\n
\"image\"<\/p>\n

Figure 18.1 An Insulin Pump <\/em><\/p>\n<\/div>\n<\/div>\n<\/div>\n

\n<\/div>\n

Proteins<\/span>\u00a0may be defined as compounds of high molar mass consisting largely or entirely of chains of amino acids. Their masses range from several thousand to several million daltons (Da). In addition to carbon, hydrogen, and oxygen atoms, all proteins contain nitrogen and sulfur atoms, and many also contain phosphorus atoms and traces of other elements. Proteins serve a variety of roles in living organisms and are often classified by these biological roles, which are summarized in <\/span>Table 18.1 “Classification of Proteins by Biological Function”<\/a>. Muscle tissue is largely protein, as are skin and hair. Proteins are present in the blood, in the brain, and even in tooth enamel. Each type of cell in our bodies makes its own specialized proteins, as well as proteins common to all or most cells.<\/span><\/p>\n<\/div>\n

\n
\n

Note<\/h3>\n

The dalton<\/em> is a unit of mass used by biochemists and biologists. It is equivalent to the atomic mass unit. A 30,000 Da protein has a molar mass of 30,000 u.<\/p>\n<\/div>\n<\/div>\n

\n

Table 18.1<\/span> Classification of Proteins by Biological Function<\/p>\n\n\n\n\n\n\n\n\n\n\n\n
Classification<\/th>\nBiological Function<\/th>\nExample<\/th>\n<\/tr>\n<\/thead>\n
enzymes<\/td>\ncatalyze and provide specificity to\u00a0 biological reactions<\/td>\n\u03b1-Amylase catalyzes the hydrolysis of starch and glycogen.<\/td>\n<\/tr>\n
structural<\/td>\nprovide strength and form<\/td>\nKeratin is the primary protein of hair and wool.<\/td>\n<\/tr>\n
contractile<\/td>\nmuscle contraction; cell division<\/td>\nMyosin is one protein needed for the contraction of muscles.<\/td>\n<\/tr>\n
transport<\/td>\ntransport substances from one place to another<\/td>\nHemoglobin transports oxygen from the lungs throughout the body.<\/td>\n<\/tr>\n
regulatory<\/td>\nregulate the functioning of other proteins<\/td>\nInsulin regulates the activity of specific enzymes in the body.<\/td>\n<\/tr>\n
storage<\/td>\nprovide storage of essential nutrients<\/td>\nOvalbumin stores amino acids in the egg white that will be used by the developing bird.<\/td>\n<\/tr>\n
protection<\/td>\nprotect cells or the organism from foreign substances<\/td>\nImmunoglobulins recognize and tag foreign molecules.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n

We begin our study of proteins by looking at the properties and reactions of amino acids, which is followed by a discussion of how amino acids link covalently to form peptides and proteins. We end the chapter with a discussion of enzymes\u2014the proteins that act as catalysts in the body.<\/p>\n<\/div>\n<\/div>\n","protected":false},"author":53384,"menu_order":1,"template":"","meta":{"_candela_citation":"[]","CANDELA_OUTCOMES_GUID":"","pb_show_title":"on","pb_short_title":"","pb_subtitle":"","pb_authors":[],"pb_section_license":""},"chapter-type":[],"contributor":[],"license":[],"class_list":["post-1961","chapter","type-chapter","status-publish","hentry"],"part":1956,"_links":{"self":[{"href":"https:\/\/courses.lumenlearning.com\/suny-monroecc-orgbiochemistry\/wp-json\/pressbooks\/v2\/chapters\/1961","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/courses.lumenlearning.com\/suny-monroecc-orgbiochemistry\/wp-json\/pressbooks\/v2\/chapters"}],"about":[{"href":"https:\/\/courses.lumenlearning.com\/suny-monroecc-orgbiochemistry\/wp-json\/wp\/v2\/types\/chapter"}],"author":[{"embeddable":true,"href":"https:\/\/courses.lumenlearning.com\/suny-monroecc-orgbiochemistry\/wp-json\/wp\/v2\/users\/53384"}],"version-history":[{"count":8,"href":"https:\/\/courses.lumenlearning.com\/suny-monroecc-orgbiochemistry\/wp-json\/pressbooks\/v2\/chapters\/1961\/revisions"}],"predecessor-version":[{"id":3614,"href":"https:\/\/courses.lumenlearning.com\/suny-monroecc-orgbiochemistry\/wp-json\/pressbooks\/v2\/chapters\/1961\/revisions\/3614"}],"part":[{"href":"https:\/\/courses.lumenlearning.com\/suny-monroecc-orgbiochemistry\/wp-json\/pressbooks\/v2\/parts\/1956"}],"metadata":[{"href":"https:\/\/courses.lumenlearning.com\/suny-monroecc-orgbiochemistry\/wp-json\/pressbooks\/v2\/chapters\/1961\/metadata\/"}],"wp:attachment":[{"href":"https:\/\/courses.lumenlearning.com\/suny-monroecc-orgbiochemistry\/wp-json\/wp\/v2\/media?parent=1961"}],"wp:term":[{"taxonomy":"chapter-type","embeddable":true,"href":"https:\/\/courses.lumenlearning.com\/suny-monroecc-orgbiochemistry\/wp-json\/pressbooks\/v2\/chapter-type?post=1961"},{"taxonomy":"contributor","embeddable":true,"href":"https:\/\/courses.lumenlearning.com\/suny-monroecc-orgbiochemistry\/wp-json\/wp\/v2\/contributor?post=1961"},{"taxonomy":"license","embeddable":true,"href":"https:\/\/courses.lumenlearning.com\/suny-monroecc-orgbiochemistry\/wp-json\/wp\/v2\/license?post=1961"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}