{"id":1049,"date":"2017-10-27T16:46:42","date_gmt":"2017-10-27T16:46:42","guid":{"rendered":"https:\/\/courses.lumenlearning.com\/suny-nutrition\/?post_type=chapter&p=1049"},"modified":"2017-11-14T17:54:42","modified_gmt":"2017-11-14T17:54:42","slug":"12-92-copper-deficiency-toxicity","status":"publish","type":"chapter","link":"https:\/\/courses.lumenlearning.com\/suny-nutrition\/chapter\/12-92-copper-deficiency-toxicity\/","title":{"raw":"12.92 Copper Deficiency & Toxicity","rendered":"12.92 Copper Deficiency & Toxicity"},"content":{"raw":"
\r\n\r\nCopper deficiency is rare in humans, but results in the following symptoms1,2<\/sup>:\r\n\r\nHypochromic anemia\r\n\r\nDecreased white blood cell counts leading to decreased immune function\r\n\r\nBone abnormalities\r\n\r\nCopper deficiency can result in a secondary iron deficiency, since Fe2+ cannot be oxidized to Fe3+ to bind to transferrin. This can cause the hypochromic anemia that occurs in iron deficiency.\r\n\r\nMenke's disease is a genetic disorder that results in copper deficiency. It is believed that individuals with this disease have a mutation in ATP7A that prevents copper from leaving the enterocyte, thus preventing absorption1<\/sup>.\r\n\r\nCopper toxicity is also rare in humans, but acute toxicity results in the following symptoms1,2<\/sup>:\r\n\r\nNausea, vomiting, diarrhea, abdominal pain\r\n\r\nChronic symptoms include1,2<\/sup>:\r\n\r\nBrain, liver, and kidney damage\r\n\r\nNeurological damage\r\n\r\nWilson's disease is a genetic disorder where a mutation in ATP7B prevents copper excretion, resulting in copper toxicity. One notable symptom is that individuals with this disease have golden to greenish-brown Kayser-Fleischer rings around the edges of the cornea, as shown in the link below1,2<\/sup>.\r\n<\/colgroup>\r\n\r\n\r\n

Web Link<\/h3>\r\n\r\nKayser-Fleischer ring<\/u><\/a><\/td>\r\n<\/tr>\r\n<\/tbody>\r\n<\/table>\r\n

References & Links<\/h3>\r\n\r\n1. Gropper SS, Smith JL, Groff JL. (2008) Advanced nutrition and human metabolism. Belmont, CA: Wadsworth Publishing.\r\n\r\n2. Byrd-Bredbenner C, Moe G, Beshgetoor D, Berning J. (2009) Wardlaw's perspectives in nutrition. New York, NY: McGraw-Hill.\r\n\r\n

Link<\/h3>\r\n\r\nKayser-Fleischer ring - http:\/\/www.nejm.org\/doi\/full\/10.1056\/NEJMicm1101534#t=article\r\n\r\n<\/div>","rendered":"
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Copper deficiency is rare in humans, but results in the following symptoms1,2<\/sup>:<\/p>\n

Hypochromic anemia<\/p>\n

Decreased white blood cell counts leading to decreased immune function<\/p>\n

Bone abnormalities<\/p>\n

Copper deficiency can result in a secondary iron deficiency, since Fe2+ cannot be oxidized to Fe3+ to bind to transferrin. This can cause the hypochromic anemia that occurs in iron deficiency.<\/p>\n

Menke’s disease is a genetic disorder that results in copper deficiency. It is believed that individuals with this disease have a mutation in ATP7A that prevents copper from leaving the enterocyte, thus preventing absorption1<\/sup>.<\/p>\n

Copper toxicity is also rare in humans, but acute toxicity results in the following symptoms1,2<\/sup>:<\/p>\n

Nausea, vomiting, diarrhea, abdominal pain<\/p>\n

Chronic symptoms include1,2<\/sup>:<\/p>\n

Brain, liver, and kidney damage<\/p>\n

Neurological damage<\/p>\n

Wilson’s disease is a genetic disorder where a mutation in ATP7B prevents copper excretion, resulting in copper toxicity. One notable symptom is that individuals with this disease have golden to greenish-brown Kayser-Fleischer rings around the edges of the cornea, as shown in the link below1,2<\/sup>.<\/p>\n\n\n<\/colgroup>\n\n\n
\n

Web Link<\/h3>\n

Kayser-Fleischer ring<\/u><\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

References & Links<\/h3>\n

1. Gropper SS, Smith JL, Groff JL. (2008) Advanced nutrition and human metabolism. Belmont, CA: Wadsworth Publishing.<\/p>\n

2. Byrd-Bredbenner C, Moe G, Beshgetoor D, Berning J. (2009) Wardlaw’s perspectives in nutrition. New York, NY: McGraw-Hill.<\/p>\n

Link<\/h3>\n

Kayser-Fleischer ring – http:\/\/www.nejm.org\/doi\/full\/10.1056\/NEJMicm1101534#t=article<\/p>\n<\/div>\n\n\t\t\t

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Candela Citations<\/h3>\n\t\t\t\t\t
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