{"id":107,"date":"2019-09-30T14:03:43","date_gmt":"2019-09-30T14:03:43","guid":{"rendered":"https:\/\/courses.lumenlearning.com\/suny-public-health-in-pharmacy-practice\/chapter\/getting-to-the-point-importance-of-immunizations-for-public-health\/"},"modified":"2019-12-30T16:57:03","modified_gmt":"2019-12-30T16:57:03","slug":"getting-to-the-point-importance-of-immunizations-for-public-health","status":"publish","type":"chapter","link":"https:\/\/courses.lumenlearning.com\/suny-public-health-in-pharmacy-practice\/chapter\/getting-to-the-point-importance-of-immunizations-for-public-health\/","title":{"raw":"Getting to the point: importance of immunizations for public health","rendered":"Getting to the point: importance of immunizations for public health"},"content":{"raw":"<h2>Stephanie F. James, PhD, MBA<\/h2>\r\n<h2>Josh Rickard, PharmD, BCPS, CDE<\/h2>\r\n<h2>Lindsey Childs-Kean, PharmD, MPH, BCPS<\/h2>\r\n<div class=\"textbox key-takeaways\">\r\n<h3 class=\"import-Normal\"><strong class=\"import-Heading2Char\" lang=\"en\" xml:lang=\"en\">Topic area<\/strong><\/h3>\r\n<p class=\"import-Normal\" style=\"text-align: center\"><span lang=\"en\" xml:lang=\"en\">Immunization<\/span><span lang=\"en\" xml:lang=\"en\">s<\/span><\/p>\r\n\r\n<\/div>\r\n<div class=\"getting-to-the-point:-importance-of-immunizations-for-public-health\">\r\n<div class=\"textbox learning-objectives\">\r\n<h3>Learning Objectives<\/h3>\r\n<p class=\"import-Normal\"><span lang=\"en\" xml:lang=\"en\">At the end of this case, students will be able to:<\/span><\/p>\r\n\r\n<ul>\r\n \t<li class=\"import-Normal\"><span lang=\"en\" xml:lang=\"en\">Define herd immunity and how unvaccinated individuals are protected<\/span><\/li>\r\n \t<li class=\"import-Normal\"><span lang=\"en\" xml:lang=\"en\">Describe presumptive evidence of immunity<\/span><\/li>\r\n \t<li class=\"import-Normal\"><span lang=\"en\" xml:lang=\"en\">Explain the timeline of an antibody response<\/span><\/li>\r\n \t<li class=\"import-Normal\"><span lang=\"en\" xml:lang=\"en\">Describe counseling points to increase adult immunizations<\/span><\/li>\r\n \t<li class=\"import-Normal\"><span lang=\"en\" xml:lang=\"en\">Discuss when and how to notify public health officials of suspected infectious disease cases<\/span><\/li>\r\n<\/ul>\r\n<\/div>\r\n<h2 class=\"import-Normal\"><strong class=\"import-Heading2Char\" lang=\"en\" xml:lang=\"en\">Introduction<\/strong><\/h2>\r\n<p class=\"import-Normal\"><span lang=\"en\" xml:lang=\"en\">I<\/span><span lang=\"en\" xml:lang=\"en\">mmunizations have led to the eradication of some of the world\u2019s most deadly diseases (such as smallpox) and to significant decreases in incidence of diseases such as rubella and measles. Total eradication is achieved when there is no circulating disease and no further measures to stop the disease are required. Despite significant gains toward the eradication of several infectious diseases, outbreaks may still occur, typically the result of an under-vaccinated population. In these populations, herd immunity (also known as \u201ccommunity immunity\u201d), in which a sufficient proportion of the population is protected from a disease such that transmission among members is unlikely, is insufficient to protect unvaccinated members.<\/span><a href=\"#s1\"><sup>1,2,3<\/sup><\/a><span lang=\"en\" xml:lang=\"en\"> The Office of Disease Prevention and Health Promotion\u2019s (ODPHP) has set several goals of reducing the number of vaccine-preventable diseases in the US. Pharmacists can play a large role in reaching such public health goals by understanding how immunizations confer protection, how diseases circulate in communities and counseling all patients to receive necessary immunizations as appropriate.<\/span><a href=\"#s4\"><sup>4<\/sup><\/a><\/p>\r\n<p class=\"import-Normal\"><span lang=\"en\" xml:lang=\"en\">In 2000, measles was declared eliminated in the US, although it was and still is endemic in other countries. However, since this time, the US has seen resurgence of this vaccine-preventable disease. Resurgence and resulting outbreaks are largely caused by introduction of the virus into a community from unvaccinated, overseas travelers, followed by disease <\/span><span lang=\"en\" xml:lang=\"en\">transmission between unvaccinated individuals and those with an unknown vaccine history.<\/span><a href=\"#s5\"><sup>5,6<\/sup><\/a><span lang=\"en\" xml:lang=\"en\"> Acceptable or presumptive evidence of immunity includes written documentation of vaccination, laboratory evidence of immunity, laboratory confirmation of disease or in some cases, the age of an individual.<\/span><a href=\"#s7\"><sup>7<\/sup><\/a><span lang=\"en\" xml:lang=\"en\"> As an example, in April 2017, a measles outbreak was identified in a group of US-born children of Somali descent.<\/span><a href=\"#s8\"><sup>8<\/sup><\/a><span lang=\"en\" xml:lang=\"en\"> An investigation into the outbreak later revealed that this population had been subject to misinformation about vaccines and as a result had developed significant fears about autism. Amidst the outbreak, susceptible, unvaccinated persons believed to have been exposed to the virus were treated with post-exposure prophylaxis with a measles vaccine or immune globulin as per the Advisory Committee on Immunization Practices (ACIP) guidelines.<\/span><a href=\"#s8\"><sup>8<\/sup><\/a><span lang=\"en\" xml:lang=\"en\"> However, the development of an adequate immune response to a vaccine requires several weeks. <\/span><\/p>\r\n<p class=\"import-Normal\"><span lang=\"en\" xml:lang=\"en\">From a scientific perspective, effective vaccination involves the development of a strong antibody response. The primary exposure to an antigen of interest (or vaccine) requires B-cells to recognize the antigen, become activated and begin to produce antibodies specific to this antigen as well as memory B-cells. This process can take between one to two weeks. Hence, if an unvaccinated individual is exposed to a pathogen, it is likely that pathology may occur during this development period. Although a certain amount of protection is afforded after initial vaccination, booster vaccinations are often required to further develop memory B-cells. Such memory B-cells can then produce antibodies to the antigen of interest within one to three days with no notable pathology.<\/span><\/p>\r\n<p class=\"import-Normal\"><span lang=\"en\" xml:lang=\"en\">The CDC has developed standards for adult immunization practices which may be found on the CDC website.<\/span><a href=\"#s9\"><sup>9<\/sup><\/a> <span lang=\"en\" xml:lang=\"en\">It<\/span><span lang=\"en\" xml:lang=\"en\"> is well known that many individuals, including adults, are hesitant to receive immunizations. The reasons for adult vaccine hesitancy may be due to a variety of factors, such as complacency (not recognizing the risk of disease), lack of convenience or lack of confidence due to concerns regarding vaccine safety.<\/span><a href=\"#s10\"><sup>10<\/sup><\/a><span lang=\"en\" xml:lang=\"en\"> However, several studies have suggested that a key factor in adult immunization is a strong recommendation from their provider.<\/span><a href=\"#s11\"><sup>11<\/sup><\/a><span lang=\"en\" xml:lang=\"en\"> It is important to understand that a key factor in adults becoming immunized is a strong recommendation from healthcare providers. For example, instead of asking a <\/span><span lang=\"en\" xml:lang=\"en\">patient \u201cAre you interested in being vaccinated for pneumococcal disease today?\u201d say \u201cI see it is time you are vaccinated for pneumococcal disease, which can help prevent pneumonia. If you give me a moment, I can prepare the vaccine for you and do it right now.\u201d Pharma<\/span><span lang=\"en\" xml:lang=\"en\">cists may also use the acronym SHARE to help them remember key counseling points: <\/span><\/p>\r\n\r\n<ul>\r\n \t<li class=\"import-Normal\"><strong lang=\"en\" xml:lang=\"en\">S<\/strong><span lang=\"en\" xml:lang=\"en\">: Share why the vaccine is recommended for that particular patient <\/span><\/li>\r\n \t<li class=\"import-Normal\"><strong lang=\"en\" xml:lang=\"en\">H<\/strong><span lang=\"en\" xml:lang=\"en\">: highlight positive benefits of the vaccine <\/span><\/li>\r\n \t<li class=\"import-Normal\"><strong lang=\"en\" xml:lang=\"en\">A<\/strong><span lang=\"en\" xml:lang=\"en\">: address patient questions in lay terms <\/span><\/li>\r\n \t<li class=\"import-Normal\"><strong lang=\"en\" xml:lang=\"en\">R<\/strong><span lang=\"en\" xml:lang=\"en\">: remind that vaccines not only protect the patient, but their loved ones around them <\/span><\/li>\r\n \t<li class=\"import-Normal\"><strong lang=\"en\" xml:lang=\"en\">E<\/strong><span lang=\"en\" xml:lang=\"en\">: explain the potential costs of disease. <\/span><\/li>\r\n<\/ul>\r\n<h2 class=\"import-Normal\"><strong class=\"import-Heading2Char\" lang=\"en\" xml:lang=\"en\">Case<\/strong><\/h2>\r\n<div class=\"textbox exercises\">\r\n<h3>Scenario<\/h3>\r\n<span lang=\"en\" xml:lang=\"en\">Scenario:<\/span><span lang=\"en\" xml:lang=\"en\"> You are a pharmacist in a community pharmacy.<\/span>\r\n\r\n<\/div>\r\n<p class=\"import-Normal\"><span lang=\"en\" xml:lang=\"en\"><span style=\"text-decoration: underline\">CC<\/span>:<\/span><span lang=\"en\" xml:lang=\"en\"> \u201cI\u2019m worried the flu shot will hurt my unborn baby.\u201d<\/span><\/p>\r\n<p class=\"import-Normal\"><span lang=\"en\" xml:lang=\"en\"><span style=\"text-decoration: underline\">Patient<\/span>:<\/span><span lang=\"en\" xml:lang=\"en\"> TF is a 24-year-old female (62\u201d, 58kg), 12 weeks pregnant with her second child. Her first child is a four-year-old male and was diagnosed with autism spectrum disorder (ASD) when he was three years old. <\/span><\/p>\r\n<p class=\"import-Normal\"><span style=\"text-decoration: underline\"><span lang=\"en\" xml:lang=\"en\">HPI<\/span><\/span><span lang=\"en\" xml:lang=\"en\"><span style=\"text-decoration: underline\">:<\/span> TF is at the pharmacy to pick up her prescription for prenatal vitamins. She tells you that her physician recommended that she receive an influenza vaccine. She is hesitant as her first son is on the autism spectrum, and she has heard conflicting stories about vaccines and autism. She would like more information on how vaccines work before agreeing to receive the vaccine.<\/span><\/p>\r\n<p class=\"import-Normal\"><span style=\"text-decoration: underline\"><span lang=\"en\" xml:lang=\"en\">PMH<\/span><\/span><span lang=\"en\" xml:lang=\"en\">: <\/span><\/p>\r\n\r\n<ul>\r\n \t<li class=\"import-Normal\"><span lang=\"en\" xml:lang=\"en\">First pregnancy resulted in live vaginal birth with no complications<\/span><\/li>\r\n \t<li class=\"import-Normal\"><span lang=\"en\" xml:lang=\"en\">Mild heartburn symptoms during both pregnancies<\/span><\/li>\r\n<\/ul>\r\n<p class=\"import-Normal\"><span style=\"text-decoration: underline\"><span lang=\"en\" xml:lang=\"en\">FH<\/span><\/span><span lang=\"en\" xml:lang=\"en\">:<\/span><\/p>\r\n\r\n<ul>\r\n \t<li class=\"import-Normal\"><span lang=\"en\" xml:lang=\"en\">Both parents alive but with unknown health status<\/span><\/li>\r\n \t<li class=\"import-Normal\"><span lang=\"en\" xml:lang=\"en\">No siblings<\/span><\/li>\r\n \t<li class=\"import-Normal\"><span lang=\"en\" xml:lang=\"en\">One 4 year old son with ASD, otherwise healthy<\/span><\/li>\r\n<\/ul>\r\n<p class=\"import-Normal\"><span style=\"text-decoration: underline\"><span lang=\"en\" xml:lang=\"en\">SH<\/span><span lang=\"en\" xml:lang=\"en\">:<\/span><\/span><\/p>\r\n\r\n<ul>\r\n \t<li class=\"import-Normal\"><span lang=\"en\" xml:lang=\"en\">No alcohol, tobacco, or illicit drug consumption<\/span><\/li>\r\n \t<li class=\"import-Normal\"><span lang=\"en\" xml:lang=\"en\">Lives with fianc\u00e9e and son<\/span><\/li>\r\n<\/ul>\r\n<p class=\"import-Normal\"><span style=\"text-decoration: underline\"><span lang=\"en\" xml:lang=\"en\">Medications<\/span><\/span><span lang=\"en\" xml:lang=\"en\">: <\/span><\/p>\r\n\r\n<ul>\r\n \t<li class=\"import-Normal\"><span lang=\"en\" xml:lang=\"en\">Prenatal vitamin PO daily<\/span><\/li>\r\n \t<li class=\"import-Normal\"><span lang=\"en\" xml:lang=\"en\">Calcium carbonate antacid PO as needed for heartburn<\/span><\/li>\r\n<\/ul>\r\n<p class=\"import-Normal\"><span style=\"text-decoration: underline\"><span lang=\"en\" xml:lang=\"en\">Allergies<\/span><\/span><span lang=\"en\" xml:lang=\"en\">: none<\/span><\/p>\r\n<p class=\"import-Normal\"><span style=\"text-decoration: underline\"><span lang=\"en\" xml:lang=\"en\">Vitals<\/span><\/span><span lang=\"en\" xml:lang=\"en\">: <\/span><\/p>\r\n\r\n<ul>\r\n \t<li class=\"import-Normal\"><span lang=\"en\" xml:lang=\"en\">BP 120\/70 mmHg<\/span><\/li>\r\n \t<li class=\"import-Normal\"><span lang=\"en\" xml:lang=\"en\">HR 65 bpm<\/span><\/li>\r\n<\/ul>\r\n<h2 class=\"import-Normal\"><strong class=\"import-Heading2Char\" lang=\"en\" xml:lang=\"en\">Case Questions<\/strong><\/h2>\r\n<p class=\"import-Normal\"><span lang=\"en\" xml:lang=\"en\">1. Why is vaccination after exposure to infection not as effective as prior vaccination?<\/span><\/p>\r\n<p class=\"instructor-notes\"><em lang=\"en\" xml:lang=\"en\">Vaccines are designed to create memory T and B cells which are protective in the event of exposure to a disease. They can quickly mount an immune response of high avidity antibodies to the infectious pathogen without the individual having suffer through a course of the disease. <\/em><\/p>\r\n<p class=\"import-Normal\"><span lang=\"en\" xml:lang=\"en\">2. Why is it important for pharmacists to be aware of diseases circulating within their community of practice?<\/span><\/p>\r\n<p class=\"instructor-notes\"><em lang=\"en\" xml:lang=\"en\">Community pharmacies are often one of the first places sick individuals will go before visiting a health clinic. Doing so risks exposure to many other people. Because the initial symptoms of many diseases are similar, it is important for pharmacists to recognize potential causes of disease that may be circulating in their community and report suspected cases. In doing so, pharmacists better serve their patients and community by helping them get prompt, appropriate treatment and decreasing the risk of disease spread.<\/em><\/p>\r\n<p class=\"import-Normal\"><span lang=\"en\" xml:lang=\"en\">3. How would you respond to a patient that states they do not need to vaccinate because they are healthy and can fight off most vaccine preventable diseases, such as influenza?<\/span><\/p>\r\n<p class=\"instructor-notes\"><em lang=\"en\" xml:lang=\"en\">Vaccines do not only protect those being vaccinated, but also prevents diseases from being transferred among a community. In this way those that may not be able to receive a vaccine (due to a disease or age) are protected through herd immunity.<\/em><\/p>\r\n<p class=\"import-Normal\"><span lang=\"en\" xml:lang=\"en\">4. In talking with the patient, she states she stopped vaccinating after her son\u2019s ASD diagnosis. How would you discuss this with her?<\/span><\/p>\r\n<p class=\"instructor-notes\"><em lang=\"en\" xml:lang=\"en\">Multiple studies have investigated the association between vaccines (MMR was the original vaccine implicated with falsified data) and autism and have found absolutely no connection. Depending on the patient\u2019s receptiveness and the established rapport, the pharmacist could discuss the issues with online information that is opinion, rather than fact-based. They could use vaccine information statements to discuss the potential adverse effects that are most common, and the risks of illness without vaccination. They could address individual stories the patient mentions to try to debunk circulating myths.<\/em><\/p>\r\n<p class=\"import-Normal\"><span lang=\"en\" xml:lang=\"en\">5. Describe how you could use the acronym SHARE to address this patient\u2019s concerns for her unborn baby and today\u2019s recommendation for an influenza vaccine.<\/span><\/p>\r\n<p class=\"instructor-notes\"><em lang=\"en\" xml:lang=\"en\">You could SHARE with the patient that the flu vaccine is recommended in all individuals over the age of 6 months old, including pregnant women, to prevent infection and complications from influenza. You can HIGHLIGHT that the vaccine will prevent her from getting sick with the flu and if she were to contract a different strain of the flu that her symptoms are likely to be minimal or mild. You can ADDRESS her questions by explaining that there is no clear link between autism and vaccines in any reliable studies. You can REMIND her that by getting the flu shot she is protecting herself, her unborn baby, as well as her other family member from flu. You can REMIND her that pregnant women are especially vulnerable to complications (even death) from the flu. <\/em><\/p>\r\n<p class=\"import-Normal\"><span lang=\"en\" xml:lang=\"en\">6. What other vaccination(s) will the patient need to receive during her pregnancy?<\/span><\/p>\r\n<p class=\"instructor-notes\"><em lang=\"en\" xml:lang=\"en\">In addition to the influenza vaccine, all pregnant women should receive the tetanus, diphtheria, and acellular pertussis (<\/em><em lang=\"en\" xml:lang=\"en\">Tdap<\/em><em lang=\"en\" xml:lang=\"en\">) vaccine between weeks 26 and 37 of pregnancy to protect the newborn from pertussis.<\/em><\/p>\r\n\r\n<h2 class=\"import-Normal\"><strong class=\"import-Heading2Char\" lang=\"en\" xml:lang=\"en\">Author Commentary<\/strong><\/h2>\r\n<p class=\"import-Normal\"><span lang=\"en\" xml:lang=\"en\">Immunizations are the best way to protect the general public from the spread of communicable disease. Some diseases such as influenza have several unique strains and hence yearly influenza vaccines are needed. Other vaccines prevent diseases caused by pathogens that do not change significantly over time. Without herd immunity, a population has enough potential disease vectors for a pathogen to circulate easily and infect not only the unvaccinated, but also those too young to receive vaccination or people that may be immune compromised.<\/span><\/p>\r\n<p class=\"import-Normal\"><span lang=\"en\" xml:lang=\"en\">Because many people are vaccine hesitant and do not vaccinate themselves or their children there has been a resurgence in some diseases, such as measles. According to the CDC, only 91.1% of children between ages 19-35 months old have received a measles vaccines, short of the 95% desired, and only 47% of children between six months and 17 years receive an influenza vaccine, leaving a significant portion of the population vulnerable to this disease. Vaccine hesitancy continues despite changes in vaccine formulations removing the preservative <\/span><span lang=\"en\" xml:lang=\"en\">thimerosal<\/span><span lang=\"en\" xml:lang=\"en\">, which was once blamed for adverse effects (although this has been shown to be untrue.) Vaccines are now available in prefilled syringes so preservatives are not included. <\/span><span lang=\"en\" xml:lang=\"en\">Vaccines also contain significantly few antigens than in previous years, as <\/span><span lang=\"en\" xml:lang=\"en\">vaccinologists<\/span><span lang=\"en\" xml:lang=\"en\"> have discovered the primary antigens necessary in a vaccine formulation to confer appropriate protection from disease. The use of fewer antigens has been complemented by improved vaccine adjuvants that promote reliable cell mediated and humoral responses to vaccines.<\/span><\/p>\r\n\r\n<h2 class=\"import-Normal\"><strong class=\"import-Heading2Char\" lang=\"en\" xml:lang=\"en\">Patient Approaches and Opportunities<\/strong><\/h2>\r\n<p class=\"import-Normal\"><span lang=\"en\" xml:lang=\"en\">Pharmacists are well respected and easily accessible, particularly those involved in community pharmacy. Hence, they often function as a first resource for many people and parents to gain information regarding healthcare. Thus, it is critical that pharmacists are aware of how immunizations can protect a population, especially those that are unable to receive immunizations. Pharmacists should be aware of a patient\u2019s concerns and potential hesitancy regarding vaccination and use the SHARE technique to help talk with patients. Such conversations between the pharmacist and patient may result in patients receiving appropriate referrals and care to further prevent spread of vaccine-preventable diseases.<\/span><\/p>\r\n\r\n<div class=\"textbox key-takeaways\">\r\n<h3 class=\"import-Normal\"><strong class=\"import-Heading2Char\" lang=\"en\" xml:lang=\"en\">Important Resources<\/strong><\/h3>\r\n<p class=\"import-Normal\"><em><span lang=\"en\" xml:lang=\"en\">Related chapters of interest:<\/span><\/em><\/p>\r\n\r\n<ul>\r\n \t<li class=\"import-Normal\"><a href=\"https:\/\/courses.lumenlearning.com\/suny-public-health-in-pharmacy-practice\/chapter\/deciphering-immunization-codes-making-evidence-based-recommendations\/\">Deciphering immunization codes: making evidence-based recommendations<\/a><\/li>\r\n \t<li class=\"import-Normal\"><a href=\"https:\/\/courses.lumenlearning.com\/suny-public-health-in-pharmacy-practice\/chapter\/interprofessional-collaboration-transforming-public-health-through-team-work\/\">Interprofessional collaboration: transforming public health through team work<\/a><\/li>\r\n \t<li class=\"import-Normal\"><a href=\"https:\/\/courses.lumenlearning.com\/suny-public-health-in-pharmacy-practice\/chapter\/chapter-1\/\">An ounce of prevention: pharmacy applications of the USPSTF guidelines<\/a><\/li>\r\n<\/ul>\r\n<p class=\"import-Normal\"><em lang=\"en\" xml:lang=\"en\">External resources:<\/em><\/p>\r\n\r\n<ul>\r\n \t<li class=\"import-Normal\"><span lang=\"en\" xml:lang=\"en\">Centers for Disease Control and Prevention. Immunization Schedules. <\/span><a class=\"rId203\" href=\"https:\/\/www.cdc.gov\/vaccines\/schedules\/index.html\"><span lang=\"en\" xml:lang=\"en\">https:\/\/www.cdc.gov\/vaccines\/schedules\/index.html<\/span><\/a><\/li>\r\n \t<li class=\"import-Normal\"><span lang=\"en\" xml:lang=\"en\">Immunization Action Coalition. <\/span><a class=\"rId204\" href=\"http:\/\/www.immunize.org\"><span lang=\"en\" xml:lang=\"en\">http:\/\/www.immunize.org<\/span><\/a><\/li>\r\n \t<li class=\"import-Normal\"><span lang=\"en\" xml:lang=\"en\">Centers for Disease Control and Prevention. Manual for the Surveillance of Vaccine-Preventable Diseases.<\/span> <a class=\"rId205\" href=\"https:\/\/www.cdc.gov\/vaccines\/pubs\/surv-manual\/index.html\"><span lang=\"en\" xml:lang=\"en\">https:\/\/www.cdc.gov\/vaccines\/pubs\/surv-manual\/index.html<\/span><\/a><\/li>\r\n \t<li class=\"import-Normal\"><span lang=\"en\" xml:lang=\"en\">Centers for Disease Control and Prevention. Community immunity definition.\u00a0<\/span><a href=\"https:\/\/www.cdc.gov\/vaccines\/terms\/glossary.html#commimmunity\"><span lang=\"en\" xml:lang=\"en\">https:\/\/www.cdc.gov\/vaccines\/terms\/glossary.html#commimmunity<\/span><\/a><\/li>\r\n \t<li class=\"import-Normal\"><span lang=\"en\" xml:lang=\"en\">Centers for Disease Control and Prevention. Making the Vaccine Decision. <\/span><a class=\"rId207\" href=\"https:\/\/www.cdc.gov\/vaccines\/parents\/vaccine-decision\/index.html\"><span lang=\"en\" xml:lang=\"en\">https:\/\/www.cdc.gov\/vaccines\/parents\/vaccine-decision\/index.html<\/span><\/a><\/li>\r\n<\/ul>\r\n<\/div>\r\n<div class=\"textbox shaded\">\r\n<h3 class=\"import-Normal\"><strong class=\"import-Heading2Char\" lang=\"en\" xml:lang=\"en\">References<\/strong><\/h3>\r\n<ol>\r\n \t<li class=\"import-Normal\"><span lang=\"en\" xml:lang=\"en\">Immunization Action Coalition.\u00a0<\/span><a class=\"rId208\" href=\"http:\/\/www.immunize.org\/\"><span lang=\"en\" xml:lang=\"en\">http:\/\/www.immunize.org\/<\/span><\/a><span lang=\"en\" xml:lang=\"en\">. Updated August 23, 2018.<\/span><\/li>\r\n \t<li class=\"import-Normal\"><span lang=\"en\" xml:lang=\"en\">Vaccine Glossary of Terms.\u00a0Centers for Disease Control and Prevention.\u00a0 <\/span><a href=\"https:\/\/www.cdc.gov\/vaccines\/terms\/glossary.html#commimmunity\"><span lang=\"en\" xml:lang=\"en\">https:\/\/www.cdc.gov\/vaccines\/terms\/glos<\/span><span lang=\"en\" xml:lang=\"en\">sary.html#commimmunity<\/span><\/a><span lang=\"en\" xml:lang=\"en\">. Updated August 17, 2015.\u00a0\u00a0<\/span><\/li>\r\n \t<li class=\"import-Normal\"><span lang=\"en\" xml:lang=\"en\">The History of Vaccines. The College of Physicians of Philadelphia.\u00a0<\/span><a class=\"rId210\" href=\"https:\/\/www.historyofvaccines.org\/\"><span lang=\"en\" xml:lang=\"en\">https:\/\/www.historyofvaccines.org\/<\/span><\/a><span lang=\"en\" xml:lang=\"en\">. <\/span>Accessed October 2018.<\/li>\r\n \t<li class=\"import-Normal\"><span lang=\"en\" xml:lang=\"en\">Healthy People 2020. <\/span><a class=\"rId211\" href=\"https:\/\/www.healthypeople.gov\/2020\/topics-objectives\/topic\/immunization-and-infectious-diseases\"><span lang=\"en\" xml:lang=\"en\">https:\/\/www.healthypeople.gov\/2020\/topics-objectives\/topic\/immunization-and-infectious-diseases<\/span><\/a><span lang=\"en\" xml:lang=\"en\">. Updated February 8, 2019. Accessed February 8, 2019.<\/span><\/li>\r\n \t<li class=\"import-Normal\">Phadeke VK, Bednarczyk RA, Salmon DA, Omer SB. Association between vaccine refusal and vaccine-preventable diseases in the United States: a review of measles and pertussis. <em>JAMA<\/em>. 2016;315(11):1149-58.<\/li>\r\n \t<li class=\"import-Normal\">Measles Cases and Outbreaks. Centers for Disease Control and Prevention. <a class=\"rId212\" href=\"https:\/\/www.cdc.gov\/measles\/cases-outbreaks.html\">https:\/\/www.cdc.gov\/measles\/cases-outbreaks.html<\/a>. Updated February 1, 2019. Accessed February 5, 2019.<\/li>\r\n \t<li class=\"import-Normal\">Centers for Disease Control and Prevention. Manual for the surveillance of vaccine-preventable diseases. Centers for Disease Control and Prevention,\u00a0Atlanta, GA, 2008.<\/li>\r\n \t<li class=\"import-Normal\">Hall V, Banerjee E, Kenyon C, et al. Measles outbreak \u2014 Minnesota April \u2014 May 2017. <em>MMWR\u00a0<\/em><em>Morb<\/em><em>\u00a0Mortal\u00a0<\/em><em>Wkly<\/em><em>\u00a0Rep<\/em>. 2017;66:713\u2013717.<\/li>\r\n \t<li class=\"import-Normal\">Standards for Adult Immunization Practice. Centers for Disease Control and Prevention. <a class=\"rId213\" href=\"https:\/\/www.cdc.gov\/vaccines\/hcp\/adults\/for-practice\/standards\/index.html\">https:\/\/www.cdc.gov\/vaccines\/hcp\/adults\/for-practice\/standards\/index.html<\/a>. Updated March 13, 2018. Accessed February 5, 2019.<\/li>\r\n \t<li class=\"import-Normal\"><span lang=\"en\" xml:lang=\"en\">Smith T. Vaccine rejection and hesitancy: a review and call to action. <\/span><em lang=\"en\" xml:lang=\"en\">Open Forum Infect Dis<\/em><span lang=\"en\" xml:lang=\"en\">. 2017<\/span><span lang=\"en\" xml:lang=\"en\">;4<\/span><span lang=\"en\" xml:lang=\"en\">(3).<\/span><\/li>\r\n \t<li class=\"import-Normal\"><span lang=\"en\" xml:lang=\"en\">Paterson P, <\/span><span lang=\"en\" xml:lang=\"en\">Meurice<\/span><span lang=\"en\" xml:lang=\"en\"> F, Stanberry LR, <\/span><span lang=\"en\" xml:lang=\"en\">Glismann<\/span><span lang=\"en\" xml:lang=\"en\"> S, Rosenthal SL, Larson HJ. Vaccine hesitancy and healthcare providers. <\/span><em lang=\"en\" xml:lang=\"en\">Vaccine<\/em><span lang=\"en\" xml:lang=\"en\">. 2016<\/span><span lang=\"en\" xml:lang=\"en\">;34<\/span><span lang=\"en\" xml:lang=\"en\">(52):6700-6.<\/span><\/li>\r\n<\/ol>\r\n<\/div>\r\n<div class=\"textbox examples\">\r\n<h3>Glossary and Abbreviations<\/h3>\r\n<ul>\r\n \t<li><a href=\"https:\/\/courses.lumenlearning.com\/suny-public-health-in-pharmacy-practice\/front-matter\/glossary\/\">Glossary<\/a><\/li>\r\n \t<li><a href=\"https:\/\/courses.lumenlearning.com\/suny-public-health-in-pharmacy-practice\/front-matter\/abbreviations\/\">Abbreviations<\/a><\/li>\r\n<\/ul>\r\n<\/div>\r\n<\/div>","rendered":"<h2>Stephanie F. James, PhD, MBA<\/h2>\n<h2>Josh Rickard, PharmD, BCPS, CDE<\/h2>\n<h2>Lindsey Childs-Kean, PharmD, MPH, BCPS<\/h2>\n<div class=\"textbox key-takeaways\">\n<h3 class=\"import-Normal\"><strong class=\"import-Heading2Char\" lang=\"en\" xml:lang=\"en\">Topic area<\/strong><\/h3>\n<p class=\"import-Normal\" style=\"text-align: center\"><span lang=\"en\" xml:lang=\"en\">Immunization<\/span><span lang=\"en\" xml:lang=\"en\">s<\/span><\/p>\n<\/div>\n<div class=\"getting-to-the-point:-importance-of-immunizations-for-public-health\">\n<div class=\"textbox learning-objectives\">\n<h3>Learning Objectives<\/h3>\n<p class=\"import-Normal\"><span lang=\"en\" xml:lang=\"en\">At the end of this case, students will be able to:<\/span><\/p>\n<ul>\n<li class=\"import-Normal\"><span lang=\"en\" xml:lang=\"en\">Define herd immunity and how unvaccinated individuals are protected<\/span><\/li>\n<li class=\"import-Normal\"><span lang=\"en\" xml:lang=\"en\">Describe presumptive evidence of immunity<\/span><\/li>\n<li class=\"import-Normal\"><span lang=\"en\" xml:lang=\"en\">Explain the timeline of an antibody response<\/span><\/li>\n<li class=\"import-Normal\"><span lang=\"en\" xml:lang=\"en\">Describe counseling points to increase adult immunizations<\/span><\/li>\n<li class=\"import-Normal\"><span lang=\"en\" xml:lang=\"en\">Discuss when and how to notify public health officials of suspected infectious disease cases<\/span><\/li>\n<\/ul>\n<\/div>\n<h2 class=\"import-Normal\"><strong class=\"import-Heading2Char\" lang=\"en\" xml:lang=\"en\">Introduction<\/strong><\/h2>\n<p class=\"import-Normal\"><span lang=\"en\" xml:lang=\"en\">I<\/span><span lang=\"en\" xml:lang=\"en\">mmunizations have led to the eradication of some of the world\u2019s most deadly diseases (such as smallpox) and to significant decreases in incidence of diseases such as rubella and measles. Total eradication is achieved when there is no circulating disease and no further measures to stop the disease are required. Despite significant gains toward the eradication of several infectious diseases, outbreaks may still occur, typically the result of an under-vaccinated population. In these populations, herd immunity (also known as \u201ccommunity immunity\u201d), in which a sufficient proportion of the population is protected from a disease such that transmission among members is unlikely, is insufficient to protect unvaccinated members.<\/span><a href=\"#s1\"><sup>1,2,3<\/sup><\/a><span lang=\"en\" xml:lang=\"en\"> The Office of Disease Prevention and Health Promotion\u2019s (ODPHP) has set several goals of reducing the number of vaccine-preventable diseases in the US. Pharmacists can play a large role in reaching such public health goals by understanding how immunizations confer protection, how diseases circulate in communities and counseling all patients to receive necessary immunizations as appropriate.<\/span><a href=\"#s4\"><sup>4<\/sup><\/a><\/p>\n<p class=\"import-Normal\"><span lang=\"en\" xml:lang=\"en\">In 2000, measles was declared eliminated in the US, although it was and still is endemic in other countries. However, since this time, the US has seen resurgence of this vaccine-preventable disease. Resurgence and resulting outbreaks are largely caused by introduction of the virus into a community from unvaccinated, overseas travelers, followed by disease <\/span><span lang=\"en\" xml:lang=\"en\">transmission between unvaccinated individuals and those with an unknown vaccine history.<\/span><a href=\"#s5\"><sup>5,6<\/sup><\/a><span lang=\"en\" xml:lang=\"en\"> Acceptable or presumptive evidence of immunity includes written documentation of vaccination, laboratory evidence of immunity, laboratory confirmation of disease or in some cases, the age of an individual.<\/span><a href=\"#s7\"><sup>7<\/sup><\/a><span lang=\"en\" xml:lang=\"en\"> As an example, in April 2017, a measles outbreak was identified in a group of US-born children of Somali descent.<\/span><a href=\"#s8\"><sup>8<\/sup><\/a><span lang=\"en\" xml:lang=\"en\"> An investigation into the outbreak later revealed that this population had been subject to misinformation about vaccines and as a result had developed significant fears about autism. Amidst the outbreak, susceptible, unvaccinated persons believed to have been exposed to the virus were treated with post-exposure prophylaxis with a measles vaccine or immune globulin as per the Advisory Committee on Immunization Practices (ACIP) guidelines.<\/span><a href=\"#s8\"><sup>8<\/sup><\/a><span lang=\"en\" xml:lang=\"en\"> However, the development of an adequate immune response to a vaccine requires several weeks. <\/span><\/p>\n<p class=\"import-Normal\"><span lang=\"en\" xml:lang=\"en\">From a scientific perspective, effective vaccination involves the development of a strong antibody response. The primary exposure to an antigen of interest (or vaccine) requires B-cells to recognize the antigen, become activated and begin to produce antibodies specific to this antigen as well as memory B-cells. This process can take between one to two weeks. Hence, if an unvaccinated individual is exposed to a pathogen, it is likely that pathology may occur during this development period. Although a certain amount of protection is afforded after initial vaccination, booster vaccinations are often required to further develop memory B-cells. Such memory B-cells can then produce antibodies to the antigen of interest within one to three days with no notable pathology.<\/span><\/p>\n<p class=\"import-Normal\"><span lang=\"en\" xml:lang=\"en\">The CDC has developed standards for adult immunization practices which may be found on the CDC website.<\/span><a href=\"#s9\"><sup>9<\/sup><\/a> <span lang=\"en\" xml:lang=\"en\">It<\/span><span lang=\"en\" xml:lang=\"en\"> is well known that many individuals, including adults, are hesitant to receive immunizations. The reasons for adult vaccine hesitancy may be due to a variety of factors, such as complacency (not recognizing the risk of disease), lack of convenience or lack of confidence due to concerns regarding vaccine safety.<\/span><a href=\"#s10\"><sup>10<\/sup><\/a><span lang=\"en\" xml:lang=\"en\"> However, several studies have suggested that a key factor in adult immunization is a strong recommendation from their provider.<\/span><a href=\"#s11\"><sup>11<\/sup><\/a><span lang=\"en\" xml:lang=\"en\"> It is important to understand that a key factor in adults becoming immunized is a strong recommendation from healthcare providers. For example, instead of asking a <\/span><span lang=\"en\" xml:lang=\"en\">patient \u201cAre you interested in being vaccinated for pneumococcal disease today?\u201d say \u201cI see it is time you are vaccinated for pneumococcal disease, which can help prevent pneumonia. If you give me a moment, I can prepare the vaccine for you and do it right now.\u201d Pharma<\/span><span lang=\"en\" xml:lang=\"en\">cists may also use the acronym SHARE to help them remember key counseling points: <\/span><\/p>\n<ul>\n<li class=\"import-Normal\"><strong lang=\"en\" xml:lang=\"en\">S<\/strong><span lang=\"en\" xml:lang=\"en\">: Share why the vaccine is recommended for that particular patient <\/span><\/li>\n<li class=\"import-Normal\"><strong lang=\"en\" xml:lang=\"en\">H<\/strong><span lang=\"en\" xml:lang=\"en\">: highlight positive benefits of the vaccine <\/span><\/li>\n<li class=\"import-Normal\"><strong lang=\"en\" xml:lang=\"en\">A<\/strong><span lang=\"en\" xml:lang=\"en\">: address patient questions in lay terms <\/span><\/li>\n<li class=\"import-Normal\"><strong lang=\"en\" xml:lang=\"en\">R<\/strong><span lang=\"en\" xml:lang=\"en\">: remind that vaccines not only protect the patient, but their loved ones around them <\/span><\/li>\n<li class=\"import-Normal\"><strong lang=\"en\" xml:lang=\"en\">E<\/strong><span lang=\"en\" xml:lang=\"en\">: explain the potential costs of disease. <\/span><\/li>\n<\/ul>\n<h2 class=\"import-Normal\"><strong class=\"import-Heading2Char\" lang=\"en\" xml:lang=\"en\">Case<\/strong><\/h2>\n<div class=\"textbox exercises\">\n<h3>Scenario<\/h3>\n<p><span lang=\"en\" xml:lang=\"en\">Scenario:<\/span><span lang=\"en\" xml:lang=\"en\"> You are a pharmacist in a community pharmacy.<\/span><\/p>\n<\/div>\n<p class=\"import-Normal\"><span lang=\"en\" xml:lang=\"en\"><span style=\"text-decoration: underline\">CC<\/span>:<\/span><span lang=\"en\" xml:lang=\"en\"> \u201cI\u2019m worried the flu shot will hurt my unborn baby.\u201d<\/span><\/p>\n<p class=\"import-Normal\"><span lang=\"en\" xml:lang=\"en\"><span style=\"text-decoration: underline\">Patient<\/span>:<\/span><span lang=\"en\" xml:lang=\"en\"> TF is a 24-year-old female (62\u201d, 58kg), 12 weeks pregnant with her second child. Her first child is a four-year-old male and was diagnosed with autism spectrum disorder (ASD) when he was three years old. <\/span><\/p>\n<p class=\"import-Normal\"><span style=\"text-decoration: underline\"><span lang=\"en\" xml:lang=\"en\">HPI<\/span><\/span><span lang=\"en\" xml:lang=\"en\"><span style=\"text-decoration: underline\">:<\/span> TF is at the pharmacy to pick up her prescription for prenatal vitamins. She tells you that her physician recommended that she receive an influenza vaccine. She is hesitant as her first son is on the autism spectrum, and she has heard conflicting stories about vaccines and autism. She would like more information on how vaccines work before agreeing to receive the vaccine.<\/span><\/p>\n<p class=\"import-Normal\"><span style=\"text-decoration: underline\"><span lang=\"en\" xml:lang=\"en\">PMH<\/span><\/span><span lang=\"en\" xml:lang=\"en\">: <\/span><\/p>\n<ul>\n<li class=\"import-Normal\"><span lang=\"en\" xml:lang=\"en\">First pregnancy resulted in live vaginal birth with no complications<\/span><\/li>\n<li class=\"import-Normal\"><span lang=\"en\" xml:lang=\"en\">Mild heartburn symptoms during both pregnancies<\/span><\/li>\n<\/ul>\n<p class=\"import-Normal\"><span style=\"text-decoration: underline\"><span lang=\"en\" xml:lang=\"en\">FH<\/span><\/span><span lang=\"en\" xml:lang=\"en\">:<\/span><\/p>\n<ul>\n<li class=\"import-Normal\"><span lang=\"en\" xml:lang=\"en\">Both parents alive but with unknown health status<\/span><\/li>\n<li class=\"import-Normal\"><span lang=\"en\" xml:lang=\"en\">No siblings<\/span><\/li>\n<li class=\"import-Normal\"><span lang=\"en\" xml:lang=\"en\">One 4 year old son with ASD, otherwise healthy<\/span><\/li>\n<\/ul>\n<p class=\"import-Normal\"><span style=\"text-decoration: underline\"><span lang=\"en\" xml:lang=\"en\">SH<\/span><span lang=\"en\" xml:lang=\"en\">:<\/span><\/span><\/p>\n<ul>\n<li class=\"import-Normal\"><span lang=\"en\" xml:lang=\"en\">No alcohol, tobacco, or illicit drug consumption<\/span><\/li>\n<li class=\"import-Normal\"><span lang=\"en\" xml:lang=\"en\">Lives with fianc\u00e9e and son<\/span><\/li>\n<\/ul>\n<p class=\"import-Normal\"><span style=\"text-decoration: underline\"><span lang=\"en\" xml:lang=\"en\">Medications<\/span><\/span><span lang=\"en\" xml:lang=\"en\">: <\/span><\/p>\n<ul>\n<li class=\"import-Normal\"><span lang=\"en\" xml:lang=\"en\">Prenatal vitamin PO daily<\/span><\/li>\n<li class=\"import-Normal\"><span lang=\"en\" xml:lang=\"en\">Calcium carbonate antacid PO as needed for heartburn<\/span><\/li>\n<\/ul>\n<p class=\"import-Normal\"><span style=\"text-decoration: underline\"><span lang=\"en\" xml:lang=\"en\">Allergies<\/span><\/span><span lang=\"en\" xml:lang=\"en\">: none<\/span><\/p>\n<p class=\"import-Normal\"><span style=\"text-decoration: underline\"><span lang=\"en\" xml:lang=\"en\">Vitals<\/span><\/span><span lang=\"en\" xml:lang=\"en\">: <\/span><\/p>\n<ul>\n<li class=\"import-Normal\"><span lang=\"en\" xml:lang=\"en\">BP 120\/70 mmHg<\/span><\/li>\n<li class=\"import-Normal\"><span lang=\"en\" xml:lang=\"en\">HR 65 bpm<\/span><\/li>\n<\/ul>\n<h2 class=\"import-Normal\"><strong class=\"import-Heading2Char\" lang=\"en\" xml:lang=\"en\">Case Questions<\/strong><\/h2>\n<p class=\"import-Normal\"><span lang=\"en\" xml:lang=\"en\">1. Why is vaccination after exposure to infection not as effective as prior vaccination?<\/span><\/p>\n<p class=\"instructor-notes\"><em lang=\"en\" xml:lang=\"en\">Vaccines are designed to create memory T and B cells which are protective in the event of exposure to a disease. They can quickly mount an immune response of high avidity antibodies to the infectious pathogen without the individual having suffer through a course of the disease. <\/em><\/p>\n<p class=\"import-Normal\"><span lang=\"en\" xml:lang=\"en\">2. Why is it important for pharmacists to be aware of diseases circulating within their community of practice?<\/span><\/p>\n<p class=\"instructor-notes\"><em lang=\"en\" xml:lang=\"en\">Community pharmacies are often one of the first places sick individuals will go before visiting a health clinic. Doing so risks exposure to many other people. Because the initial symptoms of many diseases are similar, it is important for pharmacists to recognize potential causes of disease that may be circulating in their community and report suspected cases. In doing so, pharmacists better serve their patients and community by helping them get prompt, appropriate treatment and decreasing the risk of disease spread.<\/em><\/p>\n<p class=\"import-Normal\"><span lang=\"en\" xml:lang=\"en\">3. How would you respond to a patient that states they do not need to vaccinate because they are healthy and can fight off most vaccine preventable diseases, such as influenza?<\/span><\/p>\n<p class=\"instructor-notes\"><em lang=\"en\" xml:lang=\"en\">Vaccines do not only protect those being vaccinated, but also prevents diseases from being transferred among a community. In this way those that may not be able to receive a vaccine (due to a disease or age) are protected through herd immunity.<\/em><\/p>\n<p class=\"import-Normal\"><span lang=\"en\" xml:lang=\"en\">4. In talking with the patient, she states she stopped vaccinating after her son\u2019s ASD diagnosis. How would you discuss this with her?<\/span><\/p>\n<p class=\"instructor-notes\"><em lang=\"en\" xml:lang=\"en\">Multiple studies have investigated the association between vaccines (MMR was the original vaccine implicated with falsified data) and autism and have found absolutely no connection. Depending on the patient\u2019s receptiveness and the established rapport, the pharmacist could discuss the issues with online information that is opinion, rather than fact-based. They could use vaccine information statements to discuss the potential adverse effects that are most common, and the risks of illness without vaccination. They could address individual stories the patient mentions to try to debunk circulating myths.<\/em><\/p>\n<p class=\"import-Normal\"><span lang=\"en\" xml:lang=\"en\">5. Describe how you could use the acronym SHARE to address this patient\u2019s concerns for her unborn baby and today\u2019s recommendation for an influenza vaccine.<\/span><\/p>\n<p class=\"instructor-notes\"><em lang=\"en\" xml:lang=\"en\">You could SHARE with the patient that the flu vaccine is recommended in all individuals over the age of 6 months old, including pregnant women, to prevent infection and complications from influenza. You can HIGHLIGHT that the vaccine will prevent her from getting sick with the flu and if she were to contract a different strain of the flu that her symptoms are likely to be minimal or mild. You can ADDRESS her questions by explaining that there is no clear link between autism and vaccines in any reliable studies. You can REMIND her that by getting the flu shot she is protecting herself, her unborn baby, as well as her other family member from flu. You can REMIND her that pregnant women are especially vulnerable to complications (even death) from the flu. <\/em><\/p>\n<p class=\"import-Normal\"><span lang=\"en\" xml:lang=\"en\">6. What other vaccination(s) will the patient need to receive during her pregnancy?<\/span><\/p>\n<p class=\"instructor-notes\"><em lang=\"en\" xml:lang=\"en\">In addition to the influenza vaccine, all pregnant women should receive the tetanus, diphtheria, and acellular pertussis (<\/em><em lang=\"en\" xml:lang=\"en\">Tdap<\/em><em lang=\"en\" xml:lang=\"en\">) vaccine between weeks 26 and 37 of pregnancy to protect the newborn from pertussis.<\/em><\/p>\n<h2 class=\"import-Normal\"><strong class=\"import-Heading2Char\" lang=\"en\" xml:lang=\"en\">Author Commentary<\/strong><\/h2>\n<p class=\"import-Normal\"><span lang=\"en\" xml:lang=\"en\">Immunizations are the best way to protect the general public from the spread of communicable disease. Some diseases such as influenza have several unique strains and hence yearly influenza vaccines are needed. Other vaccines prevent diseases caused by pathogens that do not change significantly over time. Without herd immunity, a population has enough potential disease vectors for a pathogen to circulate easily and infect not only the unvaccinated, but also those too young to receive vaccination or people that may be immune compromised.<\/span><\/p>\n<p class=\"import-Normal\"><span lang=\"en\" xml:lang=\"en\">Because many people are vaccine hesitant and do not vaccinate themselves or their children there has been a resurgence in some diseases, such as measles. According to the CDC, only 91.1% of children between ages 19-35 months old have received a measles vaccines, short of the 95% desired, and only 47% of children between six months and 17 years receive an influenza vaccine, leaving a significant portion of the population vulnerable to this disease. Vaccine hesitancy continues despite changes in vaccine formulations removing the preservative <\/span><span lang=\"en\" xml:lang=\"en\">thimerosal<\/span><span lang=\"en\" xml:lang=\"en\">, which was once blamed for adverse effects (although this has been shown to be untrue.) Vaccines are now available in prefilled syringes so preservatives are not included. <\/span><span lang=\"en\" xml:lang=\"en\">Vaccines also contain significantly few antigens than in previous years, as <\/span><span lang=\"en\" xml:lang=\"en\">vaccinologists<\/span><span lang=\"en\" xml:lang=\"en\"> have discovered the primary antigens necessary in a vaccine formulation to confer appropriate protection from disease. The use of fewer antigens has been complemented by improved vaccine adjuvants that promote reliable cell mediated and humoral responses to vaccines.<\/span><\/p>\n<h2 class=\"import-Normal\"><strong class=\"import-Heading2Char\" lang=\"en\" xml:lang=\"en\">Patient Approaches and Opportunities<\/strong><\/h2>\n<p class=\"import-Normal\"><span lang=\"en\" xml:lang=\"en\">Pharmacists are well respected and easily accessible, particularly those involved in community pharmacy. Hence, they often function as a first resource for many people and parents to gain information regarding healthcare. Thus, it is critical that pharmacists are aware of how immunizations can protect a population, especially those that are unable to receive immunizations. Pharmacists should be aware of a patient\u2019s concerns and potential hesitancy regarding vaccination and use the SHARE technique to help talk with patients. Such conversations between the pharmacist and patient may result in patients receiving appropriate referrals and care to further prevent spread of vaccine-preventable diseases.<\/span><\/p>\n<div class=\"textbox key-takeaways\">\n<h3 class=\"import-Normal\"><strong class=\"import-Heading2Char\" lang=\"en\" xml:lang=\"en\">Important Resources<\/strong><\/h3>\n<p class=\"import-Normal\"><em><span lang=\"en\" xml:lang=\"en\">Related chapters of interest:<\/span><\/em><\/p>\n<ul>\n<li class=\"import-Normal\"><a href=\"https:\/\/courses.lumenlearning.com\/suny-public-health-in-pharmacy-practice\/chapter\/deciphering-immunization-codes-making-evidence-based-recommendations\/\">Deciphering immunization codes: making evidence-based recommendations<\/a><\/li>\n<li class=\"import-Normal\"><a href=\"https:\/\/courses.lumenlearning.com\/suny-public-health-in-pharmacy-practice\/chapter\/interprofessional-collaboration-transforming-public-health-through-team-work\/\">Interprofessional collaboration: transforming public health through team work<\/a><\/li>\n<li class=\"import-Normal\"><a href=\"https:\/\/courses.lumenlearning.com\/suny-public-health-in-pharmacy-practice\/chapter\/chapter-1\/\">An ounce of prevention: pharmacy applications of the USPSTF guidelines<\/a><\/li>\n<\/ul>\n<p class=\"import-Normal\"><em lang=\"en\" xml:lang=\"en\">External resources:<\/em><\/p>\n<ul>\n<li class=\"import-Normal\"><span lang=\"en\" xml:lang=\"en\">Centers for Disease Control and Prevention. Immunization Schedules. <\/span><a class=\"rId203\" href=\"https:\/\/www.cdc.gov\/vaccines\/schedules\/index.html\"><span lang=\"en\" xml:lang=\"en\">https:\/\/www.cdc.gov\/vaccines\/schedules\/index.html<\/span><\/a><\/li>\n<li class=\"import-Normal\"><span lang=\"en\" xml:lang=\"en\">Immunization Action Coalition. <\/span><a class=\"rId204\" href=\"http:\/\/www.immunize.org\"><span lang=\"en\" xml:lang=\"en\">http:\/\/www.immunize.org<\/span><\/a><\/li>\n<li class=\"import-Normal\"><span lang=\"en\" xml:lang=\"en\">Centers for Disease Control and Prevention. Manual for the Surveillance of Vaccine-Preventable Diseases.<\/span> <a class=\"rId205\" href=\"https:\/\/www.cdc.gov\/vaccines\/pubs\/surv-manual\/index.html\"><span lang=\"en\" xml:lang=\"en\">https:\/\/www.cdc.gov\/vaccines\/pubs\/surv-manual\/index.html<\/span><\/a><\/li>\n<li class=\"import-Normal\"><span lang=\"en\" xml:lang=\"en\">Centers for Disease Control and Prevention. Community immunity definition.\u00a0<\/span><a href=\"https:\/\/www.cdc.gov\/vaccines\/terms\/glossary.html#commimmunity\"><span lang=\"en\" xml:lang=\"en\">https:\/\/www.cdc.gov\/vaccines\/terms\/glossary.html#commimmunity<\/span><\/a><\/li>\n<li class=\"import-Normal\"><span lang=\"en\" xml:lang=\"en\">Centers for Disease Control and Prevention. Making the Vaccine Decision. <\/span><a class=\"rId207\" href=\"https:\/\/www.cdc.gov\/vaccines\/parents\/vaccine-decision\/index.html\"><span lang=\"en\" xml:lang=\"en\">https:\/\/www.cdc.gov\/vaccines\/parents\/vaccine-decision\/index.html<\/span><\/a><\/li>\n<\/ul>\n<\/div>\n<div class=\"textbox shaded\">\n<h3 class=\"import-Normal\"><strong class=\"import-Heading2Char\" lang=\"en\" xml:lang=\"en\">References<\/strong><\/h3>\n<ol>\n<li class=\"import-Normal\"><span lang=\"en\" xml:lang=\"en\">Immunization Action Coalition.\u00a0<\/span><a class=\"rId208\" href=\"http:\/\/www.immunize.org\/\"><span lang=\"en\" xml:lang=\"en\">http:\/\/www.immunize.org\/<\/span><\/a><span lang=\"en\" xml:lang=\"en\">. Updated August 23, 2018.<\/span><\/li>\n<li class=\"import-Normal\"><span lang=\"en\" xml:lang=\"en\">Vaccine Glossary of Terms.\u00a0Centers for Disease Control and Prevention.\u00a0 <\/span><a href=\"https:\/\/www.cdc.gov\/vaccines\/terms\/glossary.html#commimmunity\"><span lang=\"en\" xml:lang=\"en\">https:\/\/www.cdc.gov\/vaccines\/terms\/glos<\/span><span lang=\"en\" xml:lang=\"en\">sary.html#commimmunity<\/span><\/a><span lang=\"en\" xml:lang=\"en\">. Updated August 17, 2015.\u00a0\u00a0<\/span><\/li>\n<li class=\"import-Normal\"><span lang=\"en\" xml:lang=\"en\">The History of Vaccines. The College of Physicians of Philadelphia.\u00a0<\/span><a class=\"rId210\" href=\"https:\/\/www.historyofvaccines.org\/\"><span lang=\"en\" xml:lang=\"en\">https:\/\/www.historyofvaccines.org\/<\/span><\/a><span lang=\"en\" xml:lang=\"en\">. <\/span>Accessed October 2018.<\/li>\n<li class=\"import-Normal\"><span lang=\"en\" xml:lang=\"en\">Healthy People 2020. <\/span><a class=\"rId211\" href=\"https:\/\/www.healthypeople.gov\/2020\/topics-objectives\/topic\/immunization-and-infectious-diseases\"><span lang=\"en\" xml:lang=\"en\">https:\/\/www.healthypeople.gov\/2020\/topics-objectives\/topic\/immunization-and-infectious-diseases<\/span><\/a><span lang=\"en\" xml:lang=\"en\">. Updated February 8, 2019. Accessed February 8, 2019.<\/span><\/li>\n<li class=\"import-Normal\">Phadeke VK, Bednarczyk RA, Salmon DA, Omer SB. Association between vaccine refusal and vaccine-preventable diseases in the United States: a review of measles and pertussis. <em>JAMA<\/em>. 2016;315(11):1149-58.<\/li>\n<li class=\"import-Normal\">Measles Cases and Outbreaks. Centers for Disease Control and Prevention. <a class=\"rId212\" href=\"https:\/\/www.cdc.gov\/measles\/cases-outbreaks.html\">https:\/\/www.cdc.gov\/measles\/cases-outbreaks.html<\/a>. Updated February 1, 2019. Accessed February 5, 2019.<\/li>\n<li class=\"import-Normal\">Centers for Disease Control and Prevention. Manual for the surveillance of vaccine-preventable diseases. Centers for Disease Control and Prevention,\u00a0Atlanta, GA, 2008.<\/li>\n<li class=\"import-Normal\">Hall V, Banerjee E, Kenyon C, et al. Measles outbreak \u2014 Minnesota April \u2014 May 2017. <em>MMWR\u00a0<\/em><em>Morb<\/em><em>\u00a0Mortal\u00a0<\/em><em>Wkly<\/em><em>\u00a0Rep<\/em>. 2017;66:713\u2013717.<\/li>\n<li class=\"import-Normal\">Standards for Adult Immunization Practice. Centers for Disease Control and Prevention. <a class=\"rId213\" href=\"https:\/\/www.cdc.gov\/vaccines\/hcp\/adults\/for-practice\/standards\/index.html\">https:\/\/www.cdc.gov\/vaccines\/hcp\/adults\/for-practice\/standards\/index.html<\/a>. Updated March 13, 2018. Accessed February 5, 2019.<\/li>\n<li class=\"import-Normal\"><span lang=\"en\" xml:lang=\"en\">Smith T. Vaccine rejection and hesitancy: a review and call to action. <\/span><em lang=\"en\" xml:lang=\"en\">Open Forum Infect Dis<\/em><span lang=\"en\" xml:lang=\"en\">. 2017<\/span><span lang=\"en\" xml:lang=\"en\">;4<\/span><span lang=\"en\" xml:lang=\"en\">(3).<\/span><\/li>\n<li class=\"import-Normal\"><span lang=\"en\" xml:lang=\"en\">Paterson P, <\/span><span lang=\"en\" xml:lang=\"en\">Meurice<\/span><span lang=\"en\" xml:lang=\"en\"> F, Stanberry LR, <\/span><span lang=\"en\" xml:lang=\"en\">Glismann<\/span><span lang=\"en\" xml:lang=\"en\"> S, Rosenthal SL, Larson HJ. Vaccine hesitancy and healthcare providers. <\/span><em lang=\"en\" xml:lang=\"en\">Vaccine<\/em><span lang=\"en\" xml:lang=\"en\">. 2016<\/span><span lang=\"en\" xml:lang=\"en\">;34<\/span><span lang=\"en\" xml:lang=\"en\">(52):6700-6.<\/span><\/li>\n<\/ol>\n<\/div>\n<div class=\"textbox examples\">\n<h3>Glossary and Abbreviations<\/h3>\n<ul>\n<li><a href=\"https:\/\/courses.lumenlearning.com\/suny-public-health-in-pharmacy-practice\/front-matter\/glossary\/\">Glossary<\/a><\/li>\n<li><a href=\"https:\/\/courses.lumenlearning.com\/suny-public-health-in-pharmacy-practice\/front-matter\/abbreviations\/\">Abbreviations<\/a><\/li>\n<\/ul>\n<\/div>\n<\/div>\n\n\t\t\t <section class=\"citations-section\" role=\"contentinfo\">\n\t\t\t <h3>Candela Citations<\/h3>\n\t\t\t\t\t <div>\n\t\t\t\t\t\t <div id=\"citation-list-107\">\n\t\t\t\t\t\t\t <div class=\"licensing\"><div class=\"license-attribution-dropdown-subheading\">CC licensed content, Original<\/div><ul class=\"citation-list\"><li><strong>License<\/strong>: <em><a target=\"_blank\" rel=\"license\" href=\"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\">CC BY-NC: Attribution-NonCommercial<\/a><\/em><\/li><\/ul><\/div>\n\t\t\t\t\t\t <\/div>\n\t\t\t\t\t <\/div>\n\t\t\t <\/section>","protected":false},"author":53384,"menu_order":14,"template":"","meta":{"_candela_citation":"[{\"type\":\"original\",\"description\":\"\",\"author\":\"\",\"organization\":\"\",\"url\":\"\",\"project\":\"\",\"license\":\"cc-by-nc\",\"license_terms\":\"\"}]","CANDELA_OUTCOMES_GUID":"","pb_show_title":"on","pb_short_title":"","pb_subtitle":"","pb_authors":[],"pb_section_license":""},"chapter-type":[],"contributor":[],"license":[],"class_list":["post-107","chapter","type-chapter","status-publish","hentry"],"part":3,"_links":{"self":[{"href":"https:\/\/courses.lumenlearning.com\/suny-public-health-in-pharmacy-practice\/wp-json\/pressbooks\/v2\/chapters\/107","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/courses.lumenlearning.com\/suny-public-health-in-pharmacy-practice\/wp-json\/pressbooks\/v2\/chapters"}],"about":[{"href":"https:\/\/courses.lumenlearning.com\/suny-public-health-in-pharmacy-practice\/wp-json\/wp\/v2\/types\/chapter"}],"author":[{"embeddable":true,"href":"https:\/\/courses.lumenlearning.com\/suny-public-health-in-pharmacy-practice\/wp-json\/wp\/v2\/users\/53384"}],"version-history":[{"count":8,"href":"https:\/\/courses.lumenlearning.com\/suny-public-health-in-pharmacy-practice\/wp-json\/pressbooks\/v2\/chapters\/107\/revisions"}],"predecessor-version":[{"id":321,"href":"https:\/\/courses.lumenlearning.com\/suny-public-health-in-pharmacy-practice\/wp-json\/pressbooks\/v2\/chapters\/107\/revisions\/321"}],"part":[{"href":"https:\/\/courses.lumenlearning.com\/suny-public-health-in-pharmacy-practice\/wp-json\/pressbooks\/v2\/parts\/3"}],"metadata":[{"href":"https:\/\/courses.lumenlearning.com\/suny-public-health-in-pharmacy-practice\/wp-json\/pressbooks\/v2\/chapters\/107\/metadata\/"}],"wp:attachment":[{"href":"https:\/\/courses.lumenlearning.com\/suny-public-health-in-pharmacy-practice\/wp-json\/wp\/v2\/media?parent=107"}],"wp:term":[{"taxonomy":"chapter-type","embeddable":true,"href":"https:\/\/courses.lumenlearning.com\/suny-public-health-in-pharmacy-practice\/wp-json\/pressbooks\/v2\/chapter-type?post=107"},{"taxonomy":"contributor","embeddable":true,"href":"https:\/\/courses.lumenlearning.com\/suny-public-health-in-pharmacy-practice\/wp-json\/wp\/v2\/contributor?post=107"},{"taxonomy":"license","embeddable":true,"href":"https:\/\/courses.lumenlearning.com\/suny-public-health-in-pharmacy-practice\/wp-json\/wp\/v2\/license?post=107"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}