The Columbian Exchange transformed both sides of the Atlantic, but with dramatically disparate outcomes. New diseases wiped out entire civilizations in the Americas, while newly imported nutrient-rich foodstuffs enabled a European population boom. Spain benefited most immediately as the wealth of the Aztec and Incan Empires strengthened the Spanish monarchy. Spain used its new riches to gain an advantage over other European nations, but this advantage was soon contested.

Portugal, France, the Netherlands, and England all raced to the New World, eager to match the gains of the Spanish. Native peoples greeted the new visitors with responses ranging from welcome cooperation to aggressive violence, but the ravages of disease and the possibility of new trading relationships enabled Europeans to create settlements all along the western rim of the Atlantic world. New empires would emerge from these tenuous beginnings, and by the end of the seventeenth century, Spain would lose its privileged position to its rivals. An age of colonization had begun and, with it, a great collision of cultures commenced.