{"id":2981,"date":"2016-06-15T21:55:58","date_gmt":"2016-06-15T21:55:58","guid":{"rendered":"https:\/\/courses.lumenlearning.com\/biologyxwaymakerxmaster\/?post_type=chapter&#038;p=2981"},"modified":"2017-10-23T23:10:12","modified_gmt":"2017-10-23T23:10:12","slug":"risks-and-benefits-of-genomic-science","status":"publish","type":"chapter","link":"https:\/\/courses.lumenlearning.com\/suny-wmopen-biology1\/chapter\/risks-and-benefits-of-genomic-science\/","title":{"raw":"Risks and Benefits of Genomic Science","rendered":"Risks and Benefits of Genomic Science"},"content":{"raw":"<h2>Discuss the risks and benefits involved in applications of genetic and genomic science<\/h2>\r\nScientific developments can be used in a lot of different ways that impact our lives. In this outcome, we'll learn about the risks and benefits of genomic science.\r\n<div class=\"textbox learning-objectives\">\r\n<h3>Learning Objectives<\/h3>\r\n<ul>\r\n \t<li>Outline how genetic information is used in personal identification<\/li>\r\n \t<li>Discuss medical uses of genetic information and the potential benefits and risks of this<\/li>\r\n \t<li>Outline the potential benefits and risks associated with agricultural uses of biotechnology<\/li>\r\n<\/ul>\r\n<\/div>\r\n<h2>Genetic Information Used for Identification<\/h2>\r\n<h3>DNA as a Forensic Tool<\/h3>\r\nInformation and clues obtained from DNA samples found at crime scenes have been used as evidence in court cases, and genetic markers have been used in forensic analysis. Genomic analysis has also become useful in this field. In 2001, the first use of genomics in forensics was published. It was a collaborative attempt between academic research institutions and the FBI to solve the mysterious cases of anthrax communicated via the US Postal Service. Using microbial genomics, researchers determined that a specific strain of anthrax was used in all the mailings.\r\n<h3>Mitochondrial Genomics<\/h3>\r\nMitochondria are intracellular organelles that contain their own DNA. Mitochondrial DNA mutates at a rapid rate and is often used to study evolutionary relationships. Another feature that makes studying the mitochondrial genome interesting is that the mitochondrial DNA in most multicellular organisms is passed on only from the mother during the process of fertilization. For this reason, mitochondrial genomics is often used to trace genealogy.\r\n<h3>DNA Fingerprinting<\/h3>\r\n<strong>DNA fingerprinting<\/strong>\u00a0(also called DNA profiling, DNA testing, or DNA typing) is a forensic technique used to identify individuals by characteristics of their DNA. A DNA profile is a small set of DNA variations that is very likely to be different in all unrelated individuals, thereby being as unique to individuals as are fingerprints (hence the name for the technique).\r\n\r\nAlthough 99.9% of human DNA sequences are the same in every person, enough of the DNA is different that it is possible to distinguish one individual from another, unless they are monozygotic (\"identical\") twins. DNA fingerprinting uses repetitive sequences that are highly variable, called variable number tandem repeats (VNTRs). Modern law enforcement in particular uses short tandem repeats (STRs). STR loci are very similar between closely related individuals, but are so variable that unrelated individuals are extremely unlikely to have the same STRs. The combination of STRs used by law enforcement enable identification though because even closely related individuals will not share all the same STR loci.\r\n\r\nThe modern process of DNA fingerprinting\u00a0was developed in 1984 by Sir Alec Jeffreys, while he was working in the Department of Genetics at the University of Leicester. DNA fingerprinting can be used\u00a0to identify a person or to place a person at a crime scene and\u00a0to help clarify paternity. DNA fingerprinting has also been widely used in the study of animal and floral populations and has revolutionized the fields of zoology, botany, and agriculture.\r\n<div class=\"textbox shaded\">\r\n\r\nWatch this video on the process of DNA fingerprinting and DNA profilinghttps:\/\/youtu.be\/DbR9xMXuK7c\r\n\r\n<\/div>\r\n<h2>Medical Uses of Genetic Information<\/h2>\r\n<h3>Personalized Medicine<\/h3>\r\nWatch this video and consider whether you would be interested in knowing details about your own personal disease risk or susceptibility.\r\n\r\n<script type=\"text\/javascript\" src=\"\/\/static.3playmedia.com\/p\/projects\/20361\/files\/1280852\/plugins\/11085.js\"><\/script><script src=\"https:\/\/www.youtube.com\/iframe_api\" type=\"text\/javascript\"><\/script>\r\n<iframe id=\"myytplayer\" src=\"https:\/\/www.youtube.com\/embed\/OON70d8gTnc?enablejsapi=1\" width=\"440\" height=\"300\" frameborder=\"0\"><\/iframe>\r\n<h3>Predicting Disease Risk at the Individual Level<\/h3>\r\nPredicting the risk of disease involves screening currently healthy individuals by genome analysis at the individual level. Intervention with lifestyle changes and drugs can be recommended before disease onset. However, this approach is most applicable when the problem resides within a single gene defect. Such defects only account for approximately 5 percent of diseases in developed countries. Most of the common diseases, such as heart disease, are multi-factored or polygenic, which is a phenotypic characteristic that involves two or more genes, and also involve environmental factors such as diet. In April 2010, scientists at Stanford University published the genome analysis of a healthy individual (Stephen Quake, a scientist at Stanford University, who had his genome sequenced); the analysis predicted his propensity to acquire various diseases. A risk assessment was performed to analyze Quake's percentage of risk for 55 different medical conditions. A rare genetic mutation was found, which showed him to be at risk for sudden heart attack. He was also predicted to have a 23 percent risk of developing prostate cancer and a 1.4 percent risk of developing Alzheimer's. The scientists used databases and several publications to analyze the genomic data. Even though genomic sequencing is becoming more affordable and analytical tools are becoming more reliable, ethical issues surrounding genomic analysis at a population level remain to be addressed.\r\n\r\nDebate remains over what to do with individual level data as well, such as the data from the genomic analysis of Quake\u2019s DNA. As a result of the study it was recommended that Quake start a regiment of preventative statins; the long-term effects of this study or treatment remain unknown at this stage.\r\n\r\n[caption id=\"attachment_1502\" align=\"alignright\" width=\"400\"]<img class=\"wp-image-1502\" src=\"https:\/\/s3-us-west-2.amazonaws.com\/courses-images\/wp-content\/uploads\/sites\/110\/2016\/05\/02201013\/Figure_B17_02_02.png\" alt=\"The PCA3 test occurs in three steps. In step one, PCA3 mRNA anneals to complementary DNA primers that are attached to beads. In step two, the mRNA is amplified using reverse-transcriptase PCR. In step three, the mRNA is detected using a chemiluminescent probe.\" width=\"400\" height=\"294\" \/> Figure 1. <em>PCA3<\/em> is a gene that is expressed in prostate epithelial cells and overexpressed in cancerous cells. A high concentration of <em>PCA3<\/em> in urine is indicative of prostate cancer. The <em>PCA3<\/em> test is considered to be a better indicator of cancer than the more well know PSA test, which measures the level of PSA (prostate-specific antigen) in the blood.[\/caption]\r\n\r\nFor example, in 2011, the United States Preventative Services Task Force recommended against using the PSA test to screen healthy men for prostate cancer. Their recommendation is based on evidence that screening does not reduce the risk of death from prostate cancer. Prostate cancer often develops very slowly and does not cause problems, while the cancer treatment can have severe side effects. The\u00a0<em>PCA3<\/em>\u00a0(Figure 1) test is considered to be more accurate, but screening may still result in men who would not have been harmed by the cancer itself suffering side effects from treatment.\r\n\r\nWhat do you think? Should all healthy men be screened for prostate cancer using the <em>PCA3<\/em> or PSA test? Should people in general be screened to find out if they have a genetic risk for cancer or other diseases?\r\n\r\nThere are no right or wrong answers to these questions. While it is true that prostate cancer treatment itself can be harmful, many men would rather be aware that they have cancer so they can monitor the disease and begin treatment if it progresses. And while genetic screening may be useful, it is expensive and may cause needless worry. People with certain risk factors may never develop the disease, and preventative treatments may do more harm than good.\r\n<h3>Pharmacogenomics and Toxicogenomics<\/h3>\r\nPharmacogenomics, also called toxicogenomics, involves evaluating the effectiveness and safety of drugs on the basis of information from an individual's genomic sequence. Genomic responses to drugs can be studied using experimental animals (such as laboratory rats or mice) or live cells in the laboratory before embarking on studies with humans. Studying changes in gene expression could provide information about the transcription profile in the presence of the drug, which can be used as an early indicator of the potential for toxic effects. For example, genes involved in cellular growth and controlled cell death, when disturbed, could lead to the growth of cancerous cells. Genome-wide studies can also help to find new genes involved in drug toxicity. Personal genome sequence information can be used to prescribe medications that will be most effective and least toxic on the basis of the individual patient's genotype. The gene signatures may not be completely accurate, but can be tested further before pathologic symptoms arise.\r\n<h3>Microbial Genomics<\/h3>\r\n<h4>Metagenomics<\/h4>\r\n[caption id=\"attachment_1503\" align=\"alignright\" width=\"400\"]<img class=\"wp-image-1503\" src=\"https:\/\/s3-us-west-2.amazonaws.com\/courses-images\/wp-content\/uploads\/sites\/110\/2016\/05\/02201134\/Figure_17_04_02.jpg\" alt=\"In metagenomics, all of the genomic DNA from a particular environment is cut into fragments and ligated into a cloning vector. The fragments, which may be from several different species, are sequenced. Regions of overlap indicate that two fragments came from the same species. Thus, the genome of each species present can be determined.\" width=\"400\" height=\"382\" \/> Figure 2. Metagenomics involves isolating DNA from multiple species within an environmental niche.[\/caption]\r\n\r\nTraditionally, microbiology has been taught with the view that microorganisms are best studied under pure culture conditions, which involves isolating a single type of cell and culturing it in the laboratory. Because microorganisms can go through several generations in a matter of hours, their gene expression profiles adapt to the new laboratory environment very quickly. In addition, the vast majority of bacterial species resist being cultured in isolation. Most microorganisms do not live as isolated entities, but in microbial communities known as biofilms. For all of these reasons, pure culture is not always the best way to study microorganisms. Metagenomics is the study of the collective genomes of multiple species that grow and interact in an environmental niche. Metagenomics can be used to identify new species more rapidly and to analyze the effect of pollutants on the environment (Figure 2).\r\n<h4>A Multitude of Benefits<\/h4>\r\nKnowledge of the genomics of microorganisms is being used to find better ways to harness biofuels from algae and cyanobacteria. The primary sources of fuel today are coal, oil, wood, and other plant products, such as ethanol. Although plants are renewable resources, there is still a need to find more alternative renewable sources of energy to meet our population's energy demands. The microbial world is one of the largest resources for genes that encode new enzymes and produce new organic compounds, and it remains largely untapped. Microorganisms are used to create products, such as enzymes that are used in research, antibiotics, and other anti-microbial mechanisms. Microbial genomics is helping to develop diagnostic tools, improved vaccines, new disease treatments, and advanced environmental cleanup techniques.\r\n<h2>Genomics in Agriculture<\/h2>\r\nGenomics can reduce the trials and failures involved in scientific research to a certain extent, which could improve the quality and quantity of crop yields in agriculture. Linking traits to genes or gene signatures helps to improve crop breeding to generate hybrids with the most desirable qualities. Scientists use genomic data to identify desirable traits, and then transfer those traits to a different organism. Scientists are discovering how genomics can improve the quality and quantity of agricultural production. For example, scientists could use desirable traits to create a useful product or enhance an existing product, such as making a drought-sensitive crop more tolerant of the dry season.\r\n<div id=\"watch-headline-title\">\r\n<h3 class=\"watch-title-container\"><span id=\"eow-title\" class=\"watch-title\" dir=\"ltr\" title=\"GMO controversies - science vs. public fear: Borut Bohanec at TEDxLjubljana\">GMO Controversies: Science versus Public Fear<\/span><\/h3>\r\nWatch Borut Bohanec, the Chair of the Department of Agronomy at the University of Ljubljana (in Slovenia), as he discusses the fears and potential benefits surrounding GMOs.\r\n\r\n<script type=\"text\/javascript\" src=\"\/\/static.3playmedia.com\/p\/projects\/20361\/files\/2048761\/plugins\/11117.js\"><\/script><script src=\"https:\/\/www.youtube.com\/iframe_api\" type=\"text\/javascript\"><\/script>\r\n<iframe id=\"myytplayer3\" src=\"https:\/\/www.youtube.com\/embed\/mz4_TwdaYeI?enablejsapi=1\" width=\"440\" height=\"300\" frameborder=\"0\"><\/iframe>\r\n<h2><strong>Check Your Understanding<\/strong><\/h2>\r\nAnswer the question(s) below to see how well you understand the topics covered in the previous section. This short quiz does\u00a0<strong>not<\/strong>\u00a0count toward your grade in the class, and you can retake it an unlimited number of times.\r\n\r\nUse this quiz to check your understanding and decide whether to (1) study the previous section further or (2) move on to the next section.\r\n\r\nhttps:\/\/assessments.lumenlearning.com\/assessments\/3387\r\n\r\n<\/div>","rendered":"<h2>Discuss the risks and benefits involved in applications of genetic and genomic science<\/h2>\n<p>Scientific developments can be used in a lot of different ways that impact our lives. In this outcome, we&#8217;ll learn about the risks and benefits of genomic science.<\/p>\n<div class=\"textbox learning-objectives\">\n<h3>Learning Objectives<\/h3>\n<ul>\n<li>Outline how genetic information is used in personal identification<\/li>\n<li>Discuss medical uses of genetic information and the potential benefits and risks of this<\/li>\n<li>Outline the potential benefits and risks associated with agricultural uses of biotechnology<\/li>\n<\/ul>\n<\/div>\n<h2>Genetic Information Used for Identification<\/h2>\n<h3>DNA as a Forensic Tool<\/h3>\n<p>Information and clues obtained from DNA samples found at crime scenes have been used as evidence in court cases, and genetic markers have been used in forensic analysis. Genomic analysis has also become useful in this field. In 2001, the first use of genomics in forensics was published. It was a collaborative attempt between academic research institutions and the FBI to solve the mysterious cases of anthrax communicated via the US Postal Service. Using microbial genomics, researchers determined that a specific strain of anthrax was used in all the mailings.<\/p>\n<h3>Mitochondrial Genomics<\/h3>\n<p>Mitochondria are intracellular organelles that contain their own DNA. Mitochondrial DNA mutates at a rapid rate and is often used to study evolutionary relationships. Another feature that makes studying the mitochondrial genome interesting is that the mitochondrial DNA in most multicellular organisms is passed on only from the mother during the process of fertilization. For this reason, mitochondrial genomics is often used to trace genealogy.<\/p>\n<h3>DNA Fingerprinting<\/h3>\n<p><strong>DNA fingerprinting<\/strong>\u00a0(also called DNA profiling, DNA testing, or DNA typing) is a forensic technique used to identify individuals by characteristics of their DNA. A DNA profile is a small set of DNA variations that is very likely to be different in all unrelated individuals, thereby being as unique to individuals as are fingerprints (hence the name for the technique).<\/p>\n<p>Although 99.9% of human DNA sequences are the same in every person, enough of the DNA is different that it is possible to distinguish one individual from another, unless they are monozygotic (&#8220;identical&#8221;) twins. DNA fingerprinting uses repetitive sequences that are highly variable, called variable number tandem repeats (VNTRs). Modern law enforcement in particular uses short tandem repeats (STRs). STR loci are very similar between closely related individuals, but are so variable that unrelated individuals are extremely unlikely to have the same STRs. The combination of STRs used by law enforcement enable identification though because even closely related individuals will not share all the same STR loci.<\/p>\n<p>The modern process of DNA fingerprinting\u00a0was developed in 1984 by Sir Alec Jeffreys, while he was working in the Department of Genetics at the University of Leicester. DNA fingerprinting can be used\u00a0to identify a person or to place a person at a crime scene and\u00a0to help clarify paternity. DNA fingerprinting has also been widely used in the study of animal and floral populations and has revolutionized the fields of zoology, botany, and agriculture.<\/p>\n<div class=\"textbox shaded\">\n<p>Watch this video on the process of DNA fingerprinting and DNA profilinghttps:\/\/youtu.be\/DbR9xMXuK7c<\/p>\n<\/div>\n<h2>Medical Uses of Genetic Information<\/h2>\n<h3>Personalized Medicine<\/h3>\n<p>Watch this video and consider whether you would be interested in knowing details about your own personal disease risk or susceptibility.<\/p>\n<p><script type=\"text\/javascript\" src=\"\/\/static.3playmedia.com\/p\/projects\/20361\/files\/1280852\/plugins\/11085.js\"><\/script><script src=\"https:\/\/www.youtube.com\/iframe_api\" type=\"text\/javascript\"><\/script><br \/>\n<iframe loading=\"lazy\" id=\"myytplayer\" src=\"https:\/\/www.youtube.com\/embed\/OON70d8gTnc?enablejsapi=1\" width=\"440\" height=\"300\" frameborder=\"0\"><\/iframe><\/p>\n<h3>Predicting Disease Risk at the Individual Level<\/h3>\n<p>Predicting the risk of disease involves screening currently healthy individuals by genome analysis at the individual level. Intervention with lifestyle changes and drugs can be recommended before disease onset. However, this approach is most applicable when the problem resides within a single gene defect. Such defects only account for approximately 5 percent of diseases in developed countries. Most of the common diseases, such as heart disease, are multi-factored or polygenic, which is a phenotypic characteristic that involves two or more genes, and also involve environmental factors such as diet. In April 2010, scientists at Stanford University published the genome analysis of a healthy individual (Stephen Quake, a scientist at Stanford University, who had his genome sequenced); the analysis predicted his propensity to acquire various diseases. A risk assessment was performed to analyze Quake&#8217;s percentage of risk for 55 different medical conditions. A rare genetic mutation was found, which showed him to be at risk for sudden heart attack. He was also predicted to have a 23 percent risk of developing prostate cancer and a 1.4 percent risk of developing Alzheimer&#8217;s. The scientists used databases and several publications to analyze the genomic data. Even though genomic sequencing is becoming more affordable and analytical tools are becoming more reliable, ethical issues surrounding genomic analysis at a population level remain to be addressed.<\/p>\n<p>Debate remains over what to do with individual level data as well, such as the data from the genomic analysis of Quake\u2019s DNA. As a result of the study it was recommended that Quake start a regiment of preventative statins; the long-term effects of this study or treatment remain unknown at this stage.<\/p>\n<div id=\"attachment_1502\" style=\"width: 410px\" class=\"wp-caption alignright\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-1502\" class=\"wp-image-1502\" src=\"https:\/\/s3-us-west-2.amazonaws.com\/courses-images\/wp-content\/uploads\/sites\/110\/2016\/05\/02201013\/Figure_B17_02_02.png\" alt=\"The PCA3 test occurs in three steps. In step one, PCA3 mRNA anneals to complementary DNA primers that are attached to beads. In step two, the mRNA is amplified using reverse-transcriptase PCR. In step three, the mRNA is detected using a chemiluminescent probe.\" width=\"400\" height=\"294\" \/><\/p>\n<p id=\"caption-attachment-1502\" class=\"wp-caption-text\">Figure 1. <em>PCA3<\/em> is a gene that is expressed in prostate epithelial cells and overexpressed in cancerous cells. A high concentration of <em>PCA3<\/em> in urine is indicative of prostate cancer. The <em>PCA3<\/em> test is considered to be a better indicator of cancer than the more well know PSA test, which measures the level of PSA (prostate-specific antigen) in the blood.<\/p>\n<\/div>\n<p>For example, in 2011, the United States Preventative Services Task Force recommended against using the PSA test to screen healthy men for prostate cancer. Their recommendation is based on evidence that screening does not reduce the risk of death from prostate cancer. Prostate cancer often develops very slowly and does not cause problems, while the cancer treatment can have severe side effects. The\u00a0<em>PCA3<\/em>\u00a0(Figure 1) test is considered to be more accurate, but screening may still result in men who would not have been harmed by the cancer itself suffering side effects from treatment.<\/p>\n<p>What do you think? Should all healthy men be screened for prostate cancer using the <em>PCA3<\/em> or PSA test? Should people in general be screened to find out if they have a genetic risk for cancer or other diseases?<\/p>\n<p>There are no right or wrong answers to these questions. While it is true that prostate cancer treatment itself can be harmful, many men would rather be aware that they have cancer so they can monitor the disease and begin treatment if it progresses. And while genetic screening may be useful, it is expensive and may cause needless worry. People with certain risk factors may never develop the disease, and preventative treatments may do more harm than good.<\/p>\n<h3>Pharmacogenomics and Toxicogenomics<\/h3>\n<p>Pharmacogenomics, also called toxicogenomics, involves evaluating the effectiveness and safety of drugs on the basis of information from an individual&#8217;s genomic sequence. Genomic responses to drugs can be studied using experimental animals (such as laboratory rats or mice) or live cells in the laboratory before embarking on studies with humans. Studying changes in gene expression could provide information about the transcription profile in the presence of the drug, which can be used as an early indicator of the potential for toxic effects. For example, genes involved in cellular growth and controlled cell death, when disturbed, could lead to the growth of cancerous cells. Genome-wide studies can also help to find new genes involved in drug toxicity. Personal genome sequence information can be used to prescribe medications that will be most effective and least toxic on the basis of the individual patient&#8217;s genotype. The gene signatures may not be completely accurate, but can be tested further before pathologic symptoms arise.<\/p>\n<h3>Microbial Genomics<\/h3>\n<h4>Metagenomics<\/h4>\n<div id=\"attachment_1503\" style=\"width: 410px\" class=\"wp-caption alignright\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-1503\" class=\"wp-image-1503\" src=\"https:\/\/s3-us-west-2.amazonaws.com\/courses-images\/wp-content\/uploads\/sites\/110\/2016\/05\/02201134\/Figure_17_04_02.jpg\" alt=\"In metagenomics, all of the genomic DNA from a particular environment is cut into fragments and ligated into a cloning vector. The fragments, which may be from several different species, are sequenced. Regions of overlap indicate that two fragments came from the same species. Thus, the genome of each species present can be determined.\" width=\"400\" height=\"382\" \/><\/p>\n<p id=\"caption-attachment-1503\" class=\"wp-caption-text\">Figure 2. Metagenomics involves isolating DNA from multiple species within an environmental niche.<\/p>\n<\/div>\n<p>Traditionally, microbiology has been taught with the view that microorganisms are best studied under pure culture conditions, which involves isolating a single type of cell and culturing it in the laboratory. Because microorganisms can go through several generations in a matter of hours, their gene expression profiles adapt to the new laboratory environment very quickly. In addition, the vast majority of bacterial species resist being cultured in isolation. Most microorganisms do not live as isolated entities, but in microbial communities known as biofilms. For all of these reasons, pure culture is not always the best way to study microorganisms. Metagenomics is the study of the collective genomes of multiple species that grow and interact in an environmental niche. Metagenomics can be used to identify new species more rapidly and to analyze the effect of pollutants on the environment (Figure 2).<\/p>\n<h4>A Multitude of Benefits<\/h4>\n<p>Knowledge of the genomics of microorganisms is being used to find better ways to harness biofuels from algae and cyanobacteria. The primary sources of fuel today are coal, oil, wood, and other plant products, such as ethanol. Although plants are renewable resources, there is still a need to find more alternative renewable sources of energy to meet our population&#8217;s energy demands. The microbial world is one of the largest resources for genes that encode new enzymes and produce new organic compounds, and it remains largely untapped. Microorganisms are used to create products, such as enzymes that are used in research, antibiotics, and other anti-microbial mechanisms. Microbial genomics is helping to develop diagnostic tools, improved vaccines, new disease treatments, and advanced environmental cleanup techniques.<\/p>\n<h2>Genomics in Agriculture<\/h2>\n<p>Genomics can reduce the trials and failures involved in scientific research to a certain extent, which could improve the quality and quantity of crop yields in agriculture. Linking traits to genes or gene signatures helps to improve crop breeding to generate hybrids with the most desirable qualities. Scientists use genomic data to identify desirable traits, and then transfer those traits to a different organism. Scientists are discovering how genomics can improve the quality and quantity of agricultural production. For example, scientists could use desirable traits to create a useful product or enhance an existing product, such as making a drought-sensitive crop more tolerant of the dry season.<\/p>\n<div id=\"watch-headline-title\">\n<h3 class=\"watch-title-container\"><span id=\"eow-title\" class=\"watch-title\" dir=\"ltr\" title=\"GMO controversies - science vs. public fear: Borut Bohanec at TEDxLjubljana\">GMO Controversies: Science versus Public Fear<\/span><\/h3>\n<p>Watch Borut Bohanec, the Chair of the Department of Agronomy at the University of Ljubljana (in Slovenia), as he discusses the fears and potential benefits surrounding GMOs.<\/p>\n<p><script type=\"text\/javascript\" src=\"\/\/static.3playmedia.com\/p\/projects\/20361\/files\/2048761\/plugins\/11117.js\"><\/script><script src=\"https:\/\/www.youtube.com\/iframe_api\" type=\"text\/javascript\"><\/script><br \/>\n<iframe loading=\"lazy\" id=\"myytplayer3\" src=\"https:\/\/www.youtube.com\/embed\/mz4_TwdaYeI?enablejsapi=1\" width=\"440\" height=\"300\" frameborder=\"0\"><\/iframe><\/p>\n<h2><strong>Check Your Understanding<\/strong><\/h2>\n<p>Answer the question(s) below to see how well you understand the topics covered in the previous section. This short quiz does\u00a0<strong>not<\/strong>\u00a0count toward your grade in the class, and you can retake it an unlimited number of times.<\/p>\n<p>Use this quiz to check your understanding and decide whether to (1) study the previous section further or (2) move on to the next section.<\/p>\n<p>\t<iframe id=\"lumen_assessment_3387\" class=\"resizable\" src=\"https:\/\/assessments.lumenlearning.com\/assessments\/load?assessment_id=3387&#38;embed=1&#38;external_user_id=&#38;external_context_id=&#38;iframe_resize_id=lumen_assessment_3387\" frameborder=\"0\" style=\"border:none;width:100%;height:100%;min-height:400px;\"><br \/>\n\t<\/iframe><\/p>\n<\/div>\n\n\t\t\t <section class=\"citations-section\" role=\"contentinfo\">\n\t\t\t <h3>Candela Citations<\/h3>\n\t\t\t\t\t <div>\n\t\t\t\t\t\t <div id=\"citation-list-2981\">\n\t\t\t\t\t\t\t <div class=\"licensing\"><div class=\"license-attribution-dropdown-subheading\">CC licensed content, Original<\/div><ul class=\"citation-list\"><li>Introduction to Risks and Benefits of Genomic Science. <strong>Authored by<\/strong>: Shelli Carter and Lumen Learning. <strong>Provided by<\/strong>: Lumen Learning. <strong>License<\/strong>: <em><a target=\"_blank\" rel=\"license\" href=\"https:\/\/creativecommons.org\/licenses\/by\/4.0\/\">CC BY: Attribution<\/a><\/em><\/li><\/ul><div class=\"license-attribution-dropdown-subheading\">CC licensed content, Shared previously<\/div><ul class=\"citation-list\"><li>Biology. <strong>Provided by<\/strong>: OpenStax CNX. <strong>Located at<\/strong>: <a target=\"_blank\" href=\"http:\/\/cnx.org\/contents\/185cbf87-c72e-48f5-b51e-f14f21b5eabd@10.8\">http:\/\/cnx.org\/contents\/185cbf87-c72e-48f5-b51e-f14f21b5eabd@10.8<\/a>. <strong>License<\/strong>: <em><a target=\"_blank\" rel=\"license\" href=\"https:\/\/creativecommons.org\/licenses\/by\/4.0\/\">CC BY: Attribution<\/a><\/em>. <strong>License Terms<\/strong>: Download for free at http:\/\/cnx.org\/contents\/185cbf87-c72e-48f5-b51e-f14f21b5eabd@10.8<\/li><li>Modification of DNA profiling. <strong>Provided by<\/strong>: Wikipedia. <strong>Located at<\/strong>: <a target=\"_blank\" href=\"https:\/\/en.wikipedia.org\/wiki\/DNA_profiling\">https:\/\/en.wikipedia.org\/wiki\/DNA_profiling<\/a>. <strong>License<\/strong>: <em><a target=\"_blank\" rel=\"license\" href=\"https:\/\/creativecommons.org\/licenses\/by-sa\/4.0\/\">CC BY-SA: Attribution-ShareAlike<\/a><\/em><\/li><\/ul><div class=\"license-attribution-dropdown-subheading\">All rights reserved content<\/div><ul class=\"citation-list\"><li>DNA Fingerprinting. <strong>Authored by<\/strong>: Bozeman Science. <strong>Located at<\/strong>: <a target=\"_blank\" href=\"https:\/\/youtu.be\/DbR9xMXuK7c\">https:\/\/youtu.be\/DbR9xMXuK7c<\/a>. <strong>License<\/strong>: <em>All Rights Reserved<\/em>. <strong>License Terms<\/strong>: Standard YouTube License<\/li><li>Personalized Medicine: Do You Want to Know?. <strong>Authored by<\/strong>: World Science Festival. <strong>Located at<\/strong>: <a target=\"_blank\" href=\"https:\/\/youtu.be\/OON70d8gTnc\">https:\/\/youtu.be\/OON70d8gTnc<\/a>. <strong>License<\/strong>: <em>All Rights Reserved<\/em>. <strong>License Terms<\/strong>: Standard YouTube License<\/li><li>GMO controversies - science vs. public fear: Borut Bohanec at TEDxLjubljana. <strong>Authored by<\/strong>: TEDx Talks. <strong>Located at<\/strong>: <a target=\"_blank\" href=\"https:\/\/youtu.be\/mz4_TwdaYeI\">https:\/\/youtu.be\/mz4_TwdaYeI<\/a>. <strong>License<\/strong>: <em>All Rights Reserved<\/em>. <strong>License Terms<\/strong>: Standard YouTube License<\/li><\/ul><\/div>\n\t\t\t\t\t\t <\/div>\n\t\t\t\t\t <\/div>\n\t\t\t <\/section>","protected":false},"author":17,"menu_order":5,"template":"","meta":{"_candela_citation":"[{\"type\":\"original\",\"description\":\"Introduction to Risks and Benefits of Genomic Science\",\"author\":\"Shelli Carter and Lumen Learning\",\"organization\":\"Lumen Learning\",\"url\":\"\",\"project\":\"\",\"license\":\"cc-by\",\"license_terms\":\"\"},{\"type\":\"cc\",\"description\":\"Biology\",\"author\":\"\",\"organization\":\"OpenStax CNX\",\"url\":\"http:\/\/cnx.org\/contents\/185cbf87-c72e-48f5-b51e-f14f21b5eabd@10.8\",\"project\":\"\",\"license\":\"cc-by\",\"license_terms\":\"Download for free at http:\/\/cnx.org\/contents\/185cbf87-c72e-48f5-b51e-f14f21b5eabd@10.8\"},{\"type\":\"copyrighted_video\",\"description\":\"DNA Fingerprinting\",\"author\":\"Bozeman Science\",\"organization\":\"\",\"url\":\"https:\/\/youtu.be\/DbR9xMXuK7c\",\"project\":\"\",\"license\":\"arr\",\"license_terms\":\"Standard YouTube License\"},{\"type\":\"cc\",\"description\":\"Modification of DNA profiling\",\"author\":\"\",\"organization\":\"Wikipedia\",\"url\":\"https:\/\/en.wikipedia.org\/wiki\/DNA_profiling\",\"project\":\"\",\"license\":\"cc-by-sa\",\"license_terms\":\"\"},{\"type\":\"copyrighted_video\",\"description\":\"Personalized Medicine: Do You Want to Know?\",\"author\":\"World Science Festival\",\"organization\":\"\",\"url\":\"https:\/\/youtu.be\/OON70d8gTnc\",\"project\":\"\",\"license\":\"arr\",\"license_terms\":\"Standard YouTube License\"},{\"type\":\"copyrighted_video\",\"description\":\"GMO controversies - 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