{"id":2952,"date":"2016-08-24T20:40:33","date_gmt":"2016-08-24T20:40:33","guid":{"rendered":"https:\/\/courses.lumenlearning.com\/umes-cheminter\/?post_type=chapter&#038;p=2952"},"modified":"2016-08-24T20:40:33","modified_gmt":"2016-08-24T20:40:33","slug":"radioisotopes-in-medical-diagnosis-and-treatment","status":"publish","type":"chapter","link":"https:\/\/courses.lumenlearning.com\/umes-cheminter\/chapter\/radioisotopes-in-medical-diagnosis-and-treatment\/","title":{"raw":"Radioisotopes in Medical Diagnosis and Treatment","rendered":"Radioisotopes in Medical Diagnosis and Treatment"},"content":{"raw":"<div class=\"x-ck12-data-objectives\">\r\n<div class=\"textbox learning-objectives\">\r\n<h3>Learning Objectives<\/h3>\r\n<ul>\r\n \t<li>List radioisotopes that are used in medical diagnosis and\/or treatment.<\/li>\r\n<\/ul>\r\n<\/div>\r\n<\/div>\r\n<p id=\"x-ck12-ODJlMDljZjVhNGMwYzRkZTdjMjBiZWQ3NGU0Mzg4Y2Y.-oer\"><strong> Why am I moving so slowly? <\/strong><\/p>\r\n<p id=\"x-ck12-YmI1NGE1OThiNWIxMGYyMDE0YWVmYTg5MDIzOTJjYjQ.-ofr\">The molecule pictured above is thyroxine, a compound produced by the thyroid gland. This molecule regulates how the body uses energy. In a condition known as hypothyroidism, the thyroid makes less thyroxine than normal. A person with this disease feels tired all the time and often puts on weight. Treatment with thyroid hormone supplements takes care of the problem.<\/p>\r\n<img class=\"aligncenter\" src=\"https:\/\/s3-us-west-2.amazonaws.com\/courses-images-archive-read-only\/wp-content\/uploads\/sites\/53\/2014\/08\/19213748\/20140811160025083599.png\" alt=\"Structure of thyroxine, which helps regulate metabolism\" width=\"560\" \/>\r\n<h2>Radioisotopes in Medical Diagnosis and Treatment<\/h2>\r\n<p id=\"x-ck12-ZmEwZTVlYTg4YzE1Mzk3NmZlOGY3ODllYzM3YjViNTc.-vb8\">Radioisotopes are widely used to diagnose disease and as effective treatment tools. For diagnosis, the isotope is administered and then located in the body using a scanner of some sort. The decay product (often gamma emission) can be located and the intensity measured. The amount of isotope taken up by the body can then give information as to the extent of the medical problem.<\/p>\r\n<p id=\"x-ck12-OTBkNGZhMWQ0MzliN2M1MjhjMmY2MmNlNmM2NGVmN2Q.-fxj\">An isotope of iodine (I-131) is used in both the diagnosis and treatment of thyroid cancer. The thyroid will normally absorb iodine to produce the iodine-containing thyroid hormones. An overactive thyroid gland will absorb the radioactive material which can then destroy excess thyroid tissue or any cancer of the thyroid. The material is sometimes used to image cancers in other parts of the body.<\/p>\r\n\r\n<div id=\"x-ck12-NWVmM2M1Yjk2NzlhOGVmNjE2MDJiMTJlY2U1NDAyZDk.-zgt\" class=\"x-ck12-img-thumbnail x-ck12-nofloat\">\r\n\r\n[caption id=\"\" align=\"alignright\" width=\"142\"]<img id=\"x-ck12-OTgwNDUtMTM2NjcxNDg4Ny0xOS0xNC0y\" src=\"https:\/\/s3-us-west-2.amazonaws.com\/courses-images-archive-read-only\/wp-content\/uploads\/sites\/53\/2014\/08\/19213750\/20140811160025360175.jpeg\" alt=\"Radioisotope scans can be used to detect tumors\" width=\"142\" height=\"192\" longdesc=\"Radioisotope%20scan%20to%20detect%20tumors.\" \/> Figure 1.\u00a0Radioisotope scan to detect tumors.[\/caption]\r\n\r\n<\/div>\r\nTechnetium-99m is perhaps the most widely used radioisotope in diagnosis and treatment (the \u201cm\u201d stands for metastable). This isotope decays to Tc-99 and a gamma emission of low intensity, making the radiation damage fairly negligible. The half-life is about six hours, so it will remain in the body for some time. Tc-99m can be used to look at cardiac damage. The isotope flows in the blood stream; if there is less blood flow in the heart, there will be less isotope concentrated in the heart muscle. Similar information can be obtained for blood flow in the brain.\r\n<p id=\"x-ck12-OTkyZmQ2ZjQwMzQ2ZjNjNWRkMDJmY2ZlNDA5N2ZlMTA.-4q6\">Isotopes can be very useful in scans to locate cancer cells. This patient has multiple tumors that have spread (metastasized) from the main tumor. A radioisotope has been attached to <strong> antibodies <\/strong> that bind to specific cancer cells. The very dark spots in the armpits, neck, and groin represent areas where tumor cells exist.<\/p>\r\n<p id=\"x-ck12-N2U1MWQ3Yjg1Y2VlMzllYjkxMjFjNjIyYjhlNDdmNGI.-y1l\">Many other examples could be presented. There are presently over 25 different isotopes in use for diagnosis and treatment. A very partial list can be seen in the <strong> Table <\/strong> below.<\/p>\r\n\r\n<table id=\"x-ck12-MTM2NjcxNTM5NDA5NQ..\" class=\"x-ck12-nofloat\" border=\"1\"><caption>Radioisotopes Employed in Diagnosis and\/or Treatment<\/caption>\r\n<tbody>\r\n<tr>\r\n<td><strong> Isotope <\/strong><\/td>\r\n<td><strong> Half-Life <\/strong><\/td>\r\n<td><strong> Application <\/strong><\/td>\r\n<\/tr>\r\n<tr>\r\n<td>Cr-51<\/td>\r\n<td>28 days<\/td>\r\n<td>labeling red blood cells<\/td>\r\n<\/tr>\r\n<tr>\r\n<td>Fe-59<\/td>\r\n<td>446 days<\/td>\r\n<td>study iron metabolism in spleen<\/td>\r\n<\/tr>\r\n<tr>\r\n<td>Xe-133<\/td>\r\n<td>5 days<\/td>\r\n<td>study lung function<\/td>\r\n<\/tr>\r\n<tr>\r\n<td>Ho-166<\/td>\r\n<td>26 hours<\/td>\r\n<td>cancer treatment<\/td>\r\n<\/tr>\r\n<\/tbody>\r\n<\/table>\r\n<h2>Summary<\/h2>\r\n<ul id=\"x-ck12-MDcwN2ZkY2ZhOTIxOTZiOTM2ZTdhYjdjNjFjMzQ1YTA.-w2d\">\r\n \t<li>Radioisotopes used in medical diagnosis and treatment are described.<\/li>\r\n<\/ul>\r\n<h3>Practice<\/h3>\r\n<p id=\"x-ck12-ZDA1NTE4MmE3ZWNhMTc1ZjZmZjlhNTc2YTQzZWI5ZTg.-mcv\">Read the material at the link below and answer the following questions:<\/p>\r\n<p id=\"x-ck12-NjYyMWEyZDM2YWUyNzAzMjVhNWFjOGJkYWEyOTEwZTc.-cgt\"><a href=\"http:\/\/www.rsc.org\/images\/essay5_tcm18-17767.pdf\"> http:\/\/www.rsc.org\/images\/essay5_tcm18-17767.pdf <\/a><\/p>\r\n\r\n<ol id=\"x-ck12-YWI2ZGM0N2M5OTUyNzVhODlmMmZmMmQ1ZmRjOTc5OWQ.-xad\">\r\n \t<li>What was the first application of radioisotopes in medicine?<\/li>\r\n \t<li>Where does Tc-99m come from?<\/li>\r\n \t<li>How does Tc99m allow us to study blood flow in the heart?<\/li>\r\n<\/ol>\r\n<h3>Review<\/h3>\r\n<ol id=\"x-ck12-MDYzNDVkMjViZGRiZjQ1MGYwNGY1MTkxMzk4ODhkMDk.-ptm\">\r\n \t<li>How does I-131 treat thyroid cancer?<\/li>\r\n \t<li>How does Tc-99m show cardiac damage?<\/li>\r\n \t<li>What isotope would you use to study red blood cells?<\/li>\r\n<\/ol>\r\n<h3 class=\"x-ck12-data-problem-set\">Glossary<\/h3>\r\n<div class=\"x-ck12-data-vocabulary\">\r\n<ul id=\"x-ck12-ZmMzMDQ0MTdjMmY4ZmE2OWI3NTBiMzI5ZDQ4YWRlNzU.-ihq\">\r\n \t<li><strong> antibody: <\/strong> A protein that attaches to a specific molecule.<\/li>\r\n<\/ul>\r\n[reveal-answer q=\"836080\"]Show References[\/reveal-answer]\r\n[hidden-answer a=\"836080\"]\r\n<h2>References<\/h2>\r\n<ol>\r\n \t<li>User:Harbin\/Wikimedia Commons. <a href=\"http:\/\/commons.wikimedia.org\/wiki\/File:Thyroxine.svg\">http:\/\/commons.wikimedia.org\/wiki\/File:Thyroxine.svg <\/a>.<\/li>\r\n \t<li>Courtesy of Dr. Jorge Carrasquillo, National Cancer Institute.<a href=\"http:\/\/commons.wikimedia.org\/wiki\/File:Monoclonal_antibodies_(9).jpg\">http:\/\/commons.wikimedia.org\/wiki\/File:Monoclonal_antibodies_(9).jpg <\/a>.<\/li>\r\n<\/ol>\r\n[\/hidden-answer]\r\n\r\n<\/div>","rendered":"<div class=\"x-ck12-data-objectives\">\n<div class=\"textbox learning-objectives\">\n<h3>Learning Objectives<\/h3>\n<ul>\n<li>List radioisotopes that are used in medical diagnosis and\/or treatment.<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<p id=\"x-ck12-ODJlMDljZjVhNGMwYzRkZTdjMjBiZWQ3NGU0Mzg4Y2Y.-oer\"><strong> Why am I moving so slowly? <\/strong><\/p>\n<p id=\"x-ck12-YmI1NGE1OThiNWIxMGYyMDE0YWVmYTg5MDIzOTJjYjQ.-ofr\">The molecule pictured above is thyroxine, a compound produced by the thyroid gland. This molecule regulates how the body uses energy. In a condition known as hypothyroidism, the thyroid makes less thyroxine than normal. A person with this disease feels tired all the time and often puts on weight. Treatment with thyroid hormone supplements takes care of the problem.<\/p>\n<p><img decoding=\"async\" class=\"aligncenter\" src=\"https:\/\/s3-us-west-2.amazonaws.com\/courses-images-archive-read-only\/wp-content\/uploads\/sites\/53\/2014\/08\/19213748\/20140811160025083599.png\" alt=\"Structure of thyroxine, which helps regulate metabolism\" width=\"560\" \/><\/p>\n<h2>Radioisotopes in Medical Diagnosis and Treatment<\/h2>\n<p id=\"x-ck12-ZmEwZTVlYTg4YzE1Mzk3NmZlOGY3ODllYzM3YjViNTc.-vb8\">Radioisotopes are widely used to diagnose disease and as effective treatment tools. For diagnosis, the isotope is administered and then located in the body using a scanner of some sort. The decay product (often gamma emission) can be located and the intensity measured. The amount of isotope taken up by the body can then give information as to the extent of the medical problem.<\/p>\n<p id=\"x-ck12-OTBkNGZhMWQ0MzliN2M1MjhjMmY2MmNlNmM2NGVmN2Q.-fxj\">An isotope of iodine (I-131) is used in both the diagnosis and treatment of thyroid cancer. The thyroid will normally absorb iodine to produce the iodine-containing thyroid hormones. An overactive thyroid gland will absorb the radioactive material which can then destroy excess thyroid tissue or any cancer of the thyroid. The material is sometimes used to image cancers in other parts of the body.<\/p>\n<div id=\"x-ck12-NWVmM2M1Yjk2NzlhOGVmNjE2MDJiMTJlY2U1NDAyZDk.-zgt\" class=\"x-ck12-img-thumbnail x-ck12-nofloat\">\n<div style=\"width: 152px\" class=\"wp-caption alignright\"><img loading=\"lazy\" decoding=\"async\" id=\"x-ck12-OTgwNDUtMTM2NjcxNDg4Ny0xOS0xNC0y\" src=\"https:\/\/s3-us-west-2.amazonaws.com\/courses-images-archive-read-only\/wp-content\/uploads\/sites\/53\/2014\/08\/19213750\/20140811160025360175.jpeg\" alt=\"Radioisotope scans can be used to detect tumors\" width=\"142\" height=\"192\" longdesc=\"Radioisotope%20scan%20to%20detect%20tumors.\" \/><\/p>\n<p class=\"wp-caption-text\">Figure 1.\u00a0Radioisotope scan to detect tumors.<\/p>\n<\/div>\n<\/div>\n<p>Technetium-99m is perhaps the most widely used radioisotope in diagnosis and treatment (the \u201cm\u201d stands for metastable). This isotope decays to Tc-99 and a gamma emission of low intensity, making the radiation damage fairly negligible. The half-life is about six hours, so it will remain in the body for some time. Tc-99m can be used to look at cardiac damage. The isotope flows in the blood stream; if there is less blood flow in the heart, there will be less isotope concentrated in the heart muscle. Similar information can be obtained for blood flow in the brain.<\/p>\n<p id=\"x-ck12-OTkyZmQ2ZjQwMzQ2ZjNjNWRkMDJmY2ZlNDA5N2ZlMTA.-4q6\">Isotopes can be very useful in scans to locate cancer cells. This patient has multiple tumors that have spread (metastasized) from the main tumor. A radioisotope has been attached to <strong> antibodies <\/strong> that bind to specific cancer cells. The very dark spots in the armpits, neck, and groin represent areas where tumor cells exist.<\/p>\n<p id=\"x-ck12-N2U1MWQ3Yjg1Y2VlMzllYjkxMjFjNjIyYjhlNDdmNGI.-y1l\">Many other examples could be presented. There are presently over 25 different isotopes in use for diagnosis and treatment. A very partial list can be seen in the <strong> Table <\/strong> below.<\/p>\n<table id=\"x-ck12-MTM2NjcxNTM5NDA5NQ..\" class=\"x-ck12-nofloat\">\n<caption>Radioisotopes Employed in Diagnosis and\/or Treatment<\/caption>\n<tbody>\n<tr>\n<td><strong> Isotope <\/strong><\/td>\n<td><strong> Half-Life <\/strong><\/td>\n<td><strong> Application <\/strong><\/td>\n<\/tr>\n<tr>\n<td>Cr-51<\/td>\n<td>28 days<\/td>\n<td>labeling red blood cells<\/td>\n<\/tr>\n<tr>\n<td>Fe-59<\/td>\n<td>446 days<\/td>\n<td>study iron metabolism in spleen<\/td>\n<\/tr>\n<tr>\n<td>Xe-133<\/td>\n<td>5 days<\/td>\n<td>study lung function<\/td>\n<\/tr>\n<tr>\n<td>Ho-166<\/td>\n<td>26 hours<\/td>\n<td>cancer treatment<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2>Summary<\/h2>\n<ul id=\"x-ck12-MDcwN2ZkY2ZhOTIxOTZiOTM2ZTdhYjdjNjFjMzQ1YTA.-w2d\">\n<li>Radioisotopes used in medical diagnosis and treatment are described.<\/li>\n<\/ul>\n<h3>Practice<\/h3>\n<p id=\"x-ck12-ZDA1NTE4MmE3ZWNhMTc1ZjZmZjlhNTc2YTQzZWI5ZTg.-mcv\">Read the material at the link below and answer the following questions:<\/p>\n<p id=\"x-ck12-NjYyMWEyZDM2YWUyNzAzMjVhNWFjOGJkYWEyOTEwZTc.-cgt\"><a href=\"http:\/\/www.rsc.org\/images\/essay5_tcm18-17767.pdf\"> http:\/\/www.rsc.org\/images\/essay5_tcm18-17767.pdf <\/a><\/p>\n<ol id=\"x-ck12-YWI2ZGM0N2M5OTUyNzVhODlmMmZmMmQ1ZmRjOTc5OWQ.-xad\">\n<li>What was the first application of radioisotopes in medicine?<\/li>\n<li>Where does Tc-99m come from?<\/li>\n<li>How does Tc99m allow us to study blood flow in the heart?<\/li>\n<\/ol>\n<h3>Review<\/h3>\n<ol id=\"x-ck12-MDYzNDVkMjViZGRiZjQ1MGYwNGY1MTkxMzk4ODhkMDk.-ptm\">\n<li>How does I-131 treat thyroid cancer?<\/li>\n<li>How does Tc-99m show cardiac damage?<\/li>\n<li>What isotope would you use to study red blood cells?<\/li>\n<\/ol>\n<h3 class=\"x-ck12-data-problem-set\">Glossary<\/h3>\n<div class=\"x-ck12-data-vocabulary\">\n<ul id=\"x-ck12-ZmMzMDQ0MTdjMmY4ZmE2OWI3NTBiMzI5ZDQ4YWRlNzU.-ihq\">\n<li><strong> antibody: <\/strong> A protein that attaches to a specific molecule.<\/li>\n<\/ul>\n<div class=\"qa-wrapper\" style=\"display: block\"><span class=\"show-answer collapsed\" style=\"cursor: pointer\" data-target=\"q836080\">Show References<\/span><\/p>\n<div id=\"q836080\" class=\"hidden-answer\" style=\"display: none\">\n<h2>References<\/h2>\n<ol>\n<li>User:Harbin\/Wikimedia Commons. <a href=\"http:\/\/commons.wikimedia.org\/wiki\/File:Thyroxine.svg\">http:\/\/commons.wikimedia.org\/wiki\/File:Thyroxine.svg <\/a>.<\/li>\n<li>Courtesy of Dr. Jorge Carrasquillo, National Cancer Institute.<a href=\"http:\/\/commons.wikimedia.org\/wiki\/File:Monoclonal_antibodies_(9).jpg\">http:\/\/commons.wikimedia.org\/wiki\/File:Monoclonal_antibodies_(9).jpg <\/a>.<\/li>\n<\/ol>\n<\/div>\n<\/div>\n<\/div>\n\n\t\t\t <section class=\"citations-section\" role=\"contentinfo\">\n\t\t\t <h3>Candela Citations<\/h3>\n\t\t\t\t\t <div>\n\t\t\t\t\t\t <div id=\"citation-list-2952\">\n\t\t\t\t\t\t\t <div class=\"licensing\"><div class=\"license-attribution-dropdown-subheading\">CC licensed content, Shared previously<\/div><ul class=\"citation-list\"><li>Chemistry Concepts Intermediate. <strong>Authored by<\/strong>: Calbreath, Baxter, et al.. <strong>Provided by<\/strong>: CK12.org. <strong>Located at<\/strong>: <a target=\"_blank\" href=\"http:\/\/www.ck12.org\/book\/CK-12-Chemistry-Concepts-Intermediate\/\">http:\/\/www.ck12.org\/book\/CK-12-Chemistry-Concepts-Intermediate\/<\/a>. <strong>License<\/strong>: <em><a target=\"_blank\" rel=\"license\" href=\"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/\">CC BY-NC: Attribution-NonCommercial<\/a><\/em><\/li><\/ul><\/div>\n\t\t\t\t\t\t <\/div>\n\t\t\t\t\t <\/div>\n\t\t\t <\/section>","protected":false},"author":17,"menu_order":13,"template":"","meta":{"_candela_citation":"[{\"type\":\"cc\",\"description\":\"Chemistry Concepts Intermediate\",\"author\":\"Calbreath, Baxter, et al.\",\"organization\":\"CK12.org\",\"url\":\"http:\/\/www.ck12.org\/book\/CK-12-Chemistry-Concepts-Intermediate\/\",\"project\":\"\",\"license\":\"cc-by-nc\",\"license_terms\":\"\"}]","CANDELA_OUTCOMES_GUID":"","pb_show_title":"on","pb_short_title":"","pb_subtitle":"","pb_authors":[],"pb_section_license":""},"chapter-type":[],"contributor":[],"license":[],"class_list":["post-2952","chapter","type-chapter","status-publish","hentry"],"part":2345,"_links":{"self":[{"href":"https:\/\/courses.lumenlearning.com\/umes-cheminter\/wp-json\/pressbooks\/v2\/chapters\/2952","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/courses.lumenlearning.com\/umes-cheminter\/wp-json\/pressbooks\/v2\/chapters"}],"about":[{"href":"https:\/\/courses.lumenlearning.com\/umes-cheminter\/wp-json\/wp\/v2\/types\/chapter"}],"author":[{"embeddable":true,"href":"https:\/\/courses.lumenlearning.com\/umes-cheminter\/wp-json\/wp\/v2\/users\/17"}],"version-history":[{"count":1,"href":"https:\/\/courses.lumenlearning.com\/umes-cheminter\/wp-json\/pressbooks\/v2\/chapters\/2952\/revisions"}],"predecessor-version":[{"id":2989,"href":"https:\/\/courses.lumenlearning.com\/umes-cheminter\/wp-json\/pressbooks\/v2\/chapters\/2952\/revisions\/2989"}],"part":[{"href":"https:\/\/courses.lumenlearning.com\/umes-cheminter\/wp-json\/pressbooks\/v2\/parts\/2345"}],"metadata":[{"href":"https:\/\/courses.lumenlearning.com\/umes-cheminter\/wp-json\/pressbooks\/v2\/chapters\/2952\/metadata\/"}],"wp:attachment":[{"href":"https:\/\/courses.lumenlearning.com\/umes-cheminter\/wp-json\/wp\/v2\/media?parent=2952"}],"wp:term":[{"taxonomy":"chapter-type","embeddable":true,"href":"https:\/\/courses.lumenlearning.com\/umes-cheminter\/wp-json\/pressbooks\/v2\/chapter-type?post=2952"},{"taxonomy":"contributor","embeddable":true,"href":"https:\/\/courses.lumenlearning.com\/umes-cheminter\/wp-json\/wp\/v2\/contributor?post=2952"},{"taxonomy":"license","embeddable":true,"href":"https:\/\/courses.lumenlearning.com\/umes-cheminter\/wp-json\/wp\/v2\/license?post=2952"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}