{"id":2767,"date":"2016-06-13T17:29:29","date_gmt":"2016-06-13T17:29:29","guid":{"rendered":"https:\/\/courses.lumenlearning.com\/biologyxwaymakerxmaster\/?post_type=chapter&#038;p=2767"},"modified":"2024-04-29T16:33:55","modified_gmt":"2024-04-29T16:33:55","slug":"putting-it-together-trait-inheritance","status":"publish","type":"chapter","link":"https:\/\/courses.lumenlearning.com\/wm-biology1\/chapter\/putting-it-together-trait-inheritance\/","title":{"raw":"Putting It Together: Trait Inheritance","rendered":"Putting It Together: Trait Inheritance"},"content":{"raw":"Now that you understand more about genetic inheritance, you can appreciate better the complications associated with predicting traits in children. Unfortunately, these complications apply to inherited disease just as much as they apply to predicting a child's height or eye color.\r\n\r\nThere are over 6,000 monogenetic disorders and thousands more polygenetic disorders. All of this is in addition to\u00a0the complications brought about by environmental influences and random genetic mutations or damage. Despite this complexity, we continually learn new things about the genetic root of human diseases. This knowledge can be used not only to predict occurrence, as a genetic counselor does, but also to develop treatments, cures, or preventatives as clinicians and researchers do.\r\n\r\nOne organization that puts this modern understanding of genetics to use is the\u00a0Dor Yeshorim,\u00a0an organization that offers genetic screening to members of the Jewish community worldwide. Its objective is to minimize, and eventually eliminate, the incidence of genetic disorders common to Jewish people, such as Tay\u2013Sachs disease.\r\n\r\n[caption id=\"attachment_4163\" align=\"alignright\" width=\"307\"]<img class=\"size-full wp-image-4163\" src=\"https:\/\/s3-us-west-2.amazonaws.com\/courses-images\/wp-content\/uploads\/sites\/1087\/2017\/01\/20172037\/Autorecessive.jpg\" alt=\"A chart showing the inheritance patterns for autosomal recessive diseases. Two carrier parents have a 25 percent chance of producing an unaffected child, a 50 percent chance of producing a carrier child, and a 25 percent chance of producing an affected child.\" width=\"307\" height=\"396\" \/> Figure 1. Tay-Sachs is an autosomal recessive disease. This means that children can only inherit the Tay-Sachs if both of their parents are carriers for the disease.[\/caption]\r\n\r\nIn both the Ashkenazi and Sephardi Jewish communities, there is an increased rate of a number of genetic disorders such as Tay\u2013Sachs disease, an autosomal recessive disorder that goes unnoticed in carriers, but is fatal within the first few years of life in almost all homozygotes.\r\n\r\nDor Yeshorim screens only for recessive traits that give rise to lethal or severely debilitating disorders, providing preventative, rather than diagnostic services. They do not screen for disorders arising from dominant gene mutations, as these cannot be prevented by informed mate selection. Orthodox Judaism generally opposes selective abortion, and although preimplantation genetic diagnosis (PGD) is often approved by Halakha, it is a difficult and costly process. By avoiding marriages between carriers of the diseases, the incidence of the disorders decreases without having to resort to these\u00a0methods.\r\n\r\nDor Yeshorim advocates anonymous testing. Individuals are tested during large sessions in Jewish schools and processed anonymously with only a PIN linking the sample with the candidate.\u00a0When two members of the system contemplate marriage, they contact the organization and enter both their PINs. When both carry a gene for the same disorder, the risk of affected offspring is 25\u00a0percent, and it is considered advisable to discontinue the plans. In the context of shidduchim (a system of matchmaking in Jewish communities), the \"carriership check\" is often run within the first three dates, to avoid disappointments and heartbreak.\r\n\r\nAccording to the Dor Yeshorim website, they are \"credited with singlehandedly eradicating Tay Sachs from the Jewish community and effectively closing the Tay Sachs ward at Kingsbrook Medical center forever.\"[footnote]\"Our History\", <em>Dor Yeshorim<\/em>,\u00a0<a href=\"https:\/\/doryeshorim.org\/history-achievements\/\" target=\"_blank\" rel=\"noopener\">https:\/\/doryeshorim.org\/history-achievements\/<\/a>.[\/footnote]\r\n<h2>Flashcards<\/h2>\r\n<div id=\"post-5211\" class=\"standard post-5211 chapter type-chapter status-publish hentry\">\r\n<div class=\"entry-content\">\r\n\r\nIt is tempting to view different topics as completely separate, but in fact the ideas we cover in this course are often connected to one another. If you don\u2019t retain the vocabulary from module to module, those connections can be missed. As you continue on, remember to come back and review the terms you\u2019ve learned in order to increase your depth of knowledge.\r\n\r\n<iframe src=\"https:\/\/lumenlearning.h5p.com\/content\/1291220403884779748\/embed\" width=\"1088\" height=\"637\" frameborder=\"0\" allowfullscreen=\"allowfullscreen\" data-mce-fragment=\"1\"><\/iframe>\r\n\r\n<\/div>\r\n<\/div>","rendered":"<p>Now that you understand more about genetic inheritance, you can appreciate better the complications associated with predicting traits in children. Unfortunately, these complications apply to inherited disease just as much as they apply to predicting a child&#8217;s height or eye color.<\/p>\n<p>There are over 6,000 monogenetic disorders and thousands more polygenetic disorders. All of this is in addition to\u00a0the complications brought about by environmental influences and random genetic mutations or damage. Despite this complexity, we continually learn new things about the genetic root of human diseases. This knowledge can be used not only to predict occurrence, as a genetic counselor does, but also to develop treatments, cures, or preventatives as clinicians and researchers do.<\/p>\n<p>One organization that puts this modern understanding of genetics to use is the\u00a0Dor Yeshorim,\u00a0an organization that offers genetic screening to members of the Jewish community worldwide. Its objective is to minimize, and eventually eliminate, the incidence of genetic disorders common to Jewish people, such as Tay\u2013Sachs disease.<\/p>\n<div id=\"attachment_4163\" style=\"width: 317px\" class=\"wp-caption alignright\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-4163\" class=\"size-full wp-image-4163\" src=\"https:\/\/s3-us-west-2.amazonaws.com\/courses-images\/wp-content\/uploads\/sites\/1087\/2017\/01\/20172037\/Autorecessive.jpg\" alt=\"A chart showing the inheritance patterns for autosomal recessive diseases. Two carrier parents have a 25 percent chance of producing an unaffected child, a 50 percent chance of producing a carrier child, and a 25 percent chance of producing an affected child.\" width=\"307\" height=\"396\" \/><\/p>\n<p id=\"caption-attachment-4163\" class=\"wp-caption-text\">Figure 1. Tay-Sachs is an autosomal recessive disease. This means that children can only inherit the Tay-Sachs if both of their parents are carriers for the disease.<\/p>\n<\/div>\n<p>In both the Ashkenazi and Sephardi Jewish communities, there is an increased rate of a number of genetic disorders such as Tay\u2013Sachs disease, an autosomal recessive disorder that goes unnoticed in carriers, but is fatal within the first few years of life in almost all homozygotes.<\/p>\n<p>Dor Yeshorim screens only for recessive traits that give rise to lethal or severely debilitating disorders, providing preventative, rather than diagnostic services. They do not screen for disorders arising from dominant gene mutations, as these cannot be prevented by informed mate selection. Orthodox Judaism generally opposes selective abortion, and although preimplantation genetic diagnosis (PGD) is often approved by Halakha, it is a difficult and costly process. By avoiding marriages between carriers of the diseases, the incidence of the disorders decreases without having to resort to these\u00a0methods.<\/p>\n<p>Dor Yeshorim advocates anonymous testing. Individuals are tested during large sessions in Jewish schools and processed anonymously with only a PIN linking the sample with the candidate.\u00a0When two members of the system contemplate marriage, they contact the organization and enter both their PINs. When both carry a gene for the same disorder, the risk of affected offspring is 25\u00a0percent, and it is considered advisable to discontinue the plans. In the context of shidduchim (a system of matchmaking in Jewish communities), the &#8220;carriership check&#8221; is often run within the first three dates, to avoid disappointments and heartbreak.<\/p>\n<p>According to the Dor Yeshorim website, they are &#8220;credited with singlehandedly eradicating Tay Sachs from the Jewish community and effectively closing the Tay Sachs ward at Kingsbrook Medical center forever.&#8221;<a class=\"footnote\" title=\"&quot;Our History&quot;, Dor Yeshorim,\u00a0https:\/\/doryeshorim.org\/history-achievements\/.\" id=\"return-footnote-2767-1\" href=\"#footnote-2767-1\" aria-label=\"Footnote 1\"><sup class=\"footnote\">[1]<\/sup><\/a><\/p>\n<h2>Flashcards<\/h2>\n<div id=\"post-5211\" class=\"standard post-5211 chapter type-chapter status-publish hentry\">\n<div class=\"entry-content\">\n<p>It is tempting to view different topics as completely separate, but in fact the ideas we cover in this course are often connected to one another. If you don\u2019t retain the vocabulary from module to module, those connections can be missed. As you continue on, remember to come back and review the terms you\u2019ve learned in order to increase your depth of knowledge.<\/p>\n<p><iframe loading=\"lazy\" src=\"https:\/\/lumenlearning.h5p.com\/content\/1291220403884779748\/embed\" width=\"1088\" height=\"637\" frameborder=\"0\" allowfullscreen=\"allowfullscreen\" data-mce-fragment=\"1\"><\/iframe><\/p>\n<\/div>\n<\/div>\n\n\t\t\t <section class=\"citations-section\" role=\"contentinfo\">\n\t\t\t <h3>Candela Citations<\/h3>\n\t\t\t\t\t <div>\n\t\t\t\t\t\t <div id=\"citation-list-2767\">\n\t\t\t\t\t\t\t <div class=\"licensing\"><div class=\"license-attribution-dropdown-subheading\">CC licensed content, Original<\/div><ul class=\"citation-list\"><li>Putting It Together: Trait Inheritance. <strong>Authored by<\/strong>: Shelli Carter and Lumen Learning. <strong>Provided by<\/strong>: Lumen Learning. <strong>License<\/strong>: <em><a target=\"_blank\" rel=\"license\" href=\"https:\/\/creativecommons.org\/licenses\/by\/4.0\/\">CC BY: Attribution<\/a><\/em><\/li><\/ul><div class=\"license-attribution-dropdown-subheading\">CC licensed content, Shared previously<\/div><ul class=\"citation-list\"><li>Modification of Dor Yeshorim. <strong>Provided by<\/strong>: Wikipedia. <strong>Located at<\/strong>: <a target=\"_blank\" href=\"https:\/\/en.wikipedia.org\/wiki\/Dor_Yeshorim\">https:\/\/en.wikipedia.org\/wiki\/Dor_Yeshorim<\/a>. <strong>License<\/strong>: <em><a target=\"_blank\" rel=\"license\" href=\"https:\/\/creativecommons.org\/licenses\/by-sa\/4.0\/\">CC BY-SA: Attribution-ShareAlike<\/a><\/em><\/li><\/ul><div class=\"license-attribution-dropdown-subheading\">Public domain content<\/div><ul class=\"citation-list\"><li>Autorecessive. <strong>Provided by<\/strong>: National Institutes of Health. <strong>Located at<\/strong>: <a target=\"_blank\" href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Autorecessive.jpg\">https:\/\/commons.wikimedia.org\/wiki\/File:Autorecessive.jpg<\/a>. <strong>License<\/strong>: <em><a target=\"_blank\" rel=\"license\" href=\"https:\/\/creativecommons.org\/about\/pdm\">Public Domain: No Known Copyright<\/a><\/em><\/li><\/ul><\/div>\n\t\t\t\t\t\t <\/div>\n\t\t\t\t\t <\/div>\n\t\t\t <\/section><hr class=\"before-footnotes clear\" \/><div class=\"footnotes\"><ol><li id=\"footnote-2767-1\">\"Our History\", <em>Dor Yeshorim<\/em>,\u00a0<a href=\"https:\/\/doryeshorim.org\/history-achievements\/\" target=\"_blank\" rel=\"noopener\">https:\/\/doryeshorim.org\/history-achievements\/<\/a>. <a href=\"#return-footnote-2767-1\" class=\"return-footnote\" aria-label=\"Return to footnote 1\">&crarr;<\/a><\/li><\/ol><\/div>","protected":false},"author":17,"menu_order":21,"template":"","meta":{"_candela_citation":"[{\"type\":\"original\",\"description\":\"Putting It Together: Trait Inheritance\",\"author\":\"Shelli Carter and Lumen Learning\",\"organization\":\"Lumen Learning\",\"url\":\"\",\"project\":\"\",\"license\":\"cc-by\",\"license_terms\":\"\"},{\"type\":\"cc\",\"description\":\"Modification of Dor Yeshorim\",\"author\":\"\",\"organization\":\"Wikipedia\",\"url\":\"https:\/\/en.wikipedia.org\/wiki\/Dor_Yeshorim\",\"project\":\"\",\"license\":\"cc-by-sa\",\"license_terms\":\"\"},{\"type\":\"pd\",\"description\":\"Autorecessive\",\"author\":\"\",\"organization\":\"National Institutes of Health\",\"url\":\"https:\/\/commons.wikimedia.org\/wiki\/File:Autorecessive.jpg\",\"project\":\"\",\"license\":\"pd\",\"license_terms\":\"\"}]","CANDELA_OUTCOMES_GUID":"7c26555e-e38b-49d4-b9cb-497c8bdbe800","pb_show_title":"on","pb_short_title":"","pb_subtitle":"","pb_authors":[],"pb_section_license":""},"chapter-type":[],"contributor":[],"license":[],"class_list":["post-2767","chapter","type-chapter","status-publish","hentry"],"part":258,"_links":{"self":[{"href":"https:\/\/courses.lumenlearning.com\/wm-biology1\/wp-json\/pressbooks\/v2\/chapters\/2767","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/courses.lumenlearning.com\/wm-biology1\/wp-json\/pressbooks\/v2\/chapters"}],"about":[{"href":"https:\/\/courses.lumenlearning.com\/wm-biology1\/wp-json\/wp\/v2\/types\/chapter"}],"author":[{"embeddable":true,"href":"https:\/\/courses.lumenlearning.com\/wm-biology1\/wp-json\/wp\/v2\/users\/17"}],"version-history":[{"count":7,"href":"https:\/\/courses.lumenlearning.com\/wm-biology1\/wp-json\/pressbooks\/v2\/chapters\/2767\/revisions"}],"predecessor-version":[{"id":6018,"href":"https:\/\/courses.lumenlearning.com\/wm-biology1\/wp-json\/pressbooks\/v2\/chapters\/2767\/revisions\/6018"}],"part":[{"href":"https:\/\/courses.lumenlearning.com\/wm-biology1\/wp-json\/pressbooks\/v2\/parts\/258"}],"metadata":[{"href":"https:\/\/courses.lumenlearning.com\/wm-biology1\/wp-json\/pressbooks\/v2\/chapters\/2767\/metadata\/"}],"wp:attachment":[{"href":"https:\/\/courses.lumenlearning.com\/wm-biology1\/wp-json\/wp\/v2\/media?parent=2767"}],"wp:term":[{"taxonomy":"chapter-type","embeddable":true,"href":"https:\/\/courses.lumenlearning.com\/wm-biology1\/wp-json\/pressbooks\/v2\/chapter-type?post=2767"},{"taxonomy":"contributor","embeddable":true,"href":"https:\/\/courses.lumenlearning.com\/wm-biology1\/wp-json\/wp\/v2\/contributor?post=2767"},{"taxonomy":"license","embeddable":true,"href":"https:\/\/courses.lumenlearning.com\/wm-biology1\/wp-json\/wp\/v2\/license?post=2767"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}