Living with a long-term or life-limiting illness fundamentally shifts a person’s identity, daily life, and overall life satisfaction. This topic covers the biopsychosocial components of adjusting to chronic diseases and evaluates the clinical interventions used to assist patients. We will also explore the deeply personal landscape of coping with terminal illness, examining the profound role that religious diversity and cultural variations play in perspectives on death, dying, grief, and end-of-life care across different genders and subcultures.