Compared to extrahepatic tissues as a whole, in the muscle the following pathways are not performed or are not important:
Fatty acid synthesis
Ketone body breakdown
These pathways are crossed out in the figure below.
Removing those pathways, the following metabolic pathways make up the muscle metabolic capability:
Glycogen synthesis and breakdown
Protein synthesis and breakdown
Triglyceride synthesis and breakdown
Fatty acid breakdown
Muscle is a major extrahepatic metabolic tissue. It is the only extrahepatic tissue with significant glycogen stores. However, unlike the liver, the muscle cannot secrete glucose after it is taken up (no glucose-6-phosphatase). Thus, you can think of the muscle as being selfish with glucose. It either uses it for itself initially or stores it for its later use.
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