Because the liver is so important in metabolism, the term extrahepatic has been defined to mean “located or occurring outside of the liver”1. We are next going to consider extrahepatic tissue metabolism.
To start considering the metabolic capabilities of the extrahepatic tissues, we start by removing pathways that only or mostly occur in the liver:
Ketone body synthesis
These metabolic processes are crossed off in the figure below.
We are left with metabolic capabilities that are listed and shown below.
Glycogen synthesis and breakdown
Fatty acid synthesis and breakdown
Triglyceride synthesis and breakdown
Protein synthesis and breakdown
We will use this figure as the base for metabolic capabilities of the different extrahepatic tissues to compare what pathways other tissues can perform versus all the pathways performed by extrahepatic tissues.
In an effort to keep this simple, we are going to focus on four extrahepatic tissues in the following subsections:
References & Links