A Nucleophilic Aromatic Displacement Reactions of Aryl Halides

The carbon-halogen bonds of aryl halides are like those of alkenyl halides in being much stronger than those of alkyl halides (see Table 4-6). The simple aryl halides generally are resistant to attack by nucleophiles in either S_N1 or S_N2 reactions (Table 14-6). However, this low reactivity can be changed dramatically by changes in the reaction conditions and the structure of the aryl halide. In fact, nucleophilic displacement becomes quite rapid

1. when the aryl halide is activated by substitution with strongly electron-attracting groups such as NO₂, and
2. when very strongly basic nucleophilic reagents are used.

Addition-Elimination Mechanism of Nucleophilic Substitution of Aryl Halides

Although simple aryl halides are inert to the usual nucleophilic reagents, considerable activation is produced by strongly electron-attracting substituents in either the ortho or para positions, or both. For example, the displacement of chloride ion from 1-chloro-2,4-dinitrobenzene by dimethylamine occurs readily in ethanol solution at room temperature. Under the same conditions chlorobenzene completely fails to react; thus the activating influence of the two nitro groups amounts to a factor of at least 108:

A related reaction is that of 2,4-dinitrofluorobenzene with the amino groups of peptides and proteins, and this reaction provides a means for analysis of the N-terminal amino acids in polypeptide chains.

In general, the reactions of activated aryl halides closely resemble the S_N2-displacement reactions of aliphatic halides. The same nucleophilic reagents are effective (e.g., CH₃O¯, HO¯, and RNH₂); the reactions are second order overall (first order in halide and first order in nucleophile); and for a given halide the more nucleophilic the attacking reagent, the faster the reaction. However, there must be more than a subtle difference in mechanism because an aryl halide is unable, to pass through the same type of transition state as an alkyl halide in S_N2 displacements.

The generally accepted mechanism of nucleophilic aromatic substitution of aryl halides carrying activating groups involves two steps. The first step involves attack of the nucleophile Nuc¯ on the carbon bearing the halogen substituent to form an intermediate (shown in the box). This intermediate is stabilized by resonance; in particular, the negative charge can be delocalized into the ortho/para electron-withdrawing group (in this example, an ortho nitro group). The aromatic system is destroyed on forming the anion, and the carbon at the reaction site changes from planar (sp² bonds) to tetrahedral (sp³ bonds).

In the second step, loss of an anion, X¯ or Nuc¯, regenerates an aromatic system, and, if X¯ is lost, the overall reaction is nucleophilic displacement of X by Nuc.  The most convenient resonance form has been used for the anion, to keep the mechanism simple.

In the case of a neutral nucleophilic reagent, HY, the reaction sequence would be the same except for the necessary adjustments in the charge of the intermediate, with a final acid-base step.

Why is this reaction pathway generally unfavorable for simple aryl halides? If no electron-withdrawing group is present, the carbons in the ring alone cannot stabilize the minus charge enough for the reaction to occur.  When strongly electron-attracting groups are located on the ring at the ortho-para positions, the intermediate anion is stabilized by delocalization of electrons from the ring carbons to more favorable locations on the substituent groups.

As another example, consider the displacement of bromine by OCH₃ in the reaction of 4-bromonitrobenzene and methoxide ion:

The anionic intermediate formed by addition of methoxide ion to the aryl halide can be described by the valence-bond structures 5a-5d. Of these structures 5d is especially important because in it the charge is transferred from the ring carbons to the oxygen of the nitro substituent:

Substituents in the meta positions have much less effect on the reactivity of an aryl halide because delocalization of electrons to the substituent is not possible. No formulas can be written analogous to 5c and 5d in which the negative charges are both on atoms next to positive nitrogen, and

In a few instances, stable compounds resembling the postulated reaction intermediate have been isolated. One classic example is the complex 7 (isolated by J. Meisenheimer), which is the product of the reaction of either the methyl aryl ether 6 with potassium ethoxide, or the ethyl aryl ether 8 and potassium methoxide:

Exercises

Questions

Q16.7.1

Propose a mechanism for the following reaction:

Solutions

S16.7.1

Khan academy video

Contributors

• Dr. Dietmar Kennepohl FCIC (Professor of Chemistry, Athabasca University)
• Prof. Steven Farmer (Sonoma State University)
• William Reusch, Professor Emeritus (Michigan State U.), Virtual Textbook of Organic Chemistry

• John D. Robert and Marjorie C. Caserio (1977) Basic Principles of Organic Chemistry, second edition. W. A. Benjamin, Inc. , Menlo Park, CA. ISBN 0-8053-8329-8. This content is copyrighted under the following conditions, “You are granted permission for individual, educational, research and non-commercial reproduction, distribution, display and performance of this work in any format.”